A 22-year-old G1P1 woman comes to the clinic asking about “the morning after pill.” She reports that she had sexual intercourse with her boyfriend last night and she thinks the condom broke. She is not using any other form of contraception. She reports her last menstrual period was 10 days ago, and they are normally regular. The patient’s medical history is significant for obesity, asthma and allergic rhinitis. Her medications include albuterol and occasional intranasal corticosteroids. She has no history of sexually transmitted diseases and is sexually active with only her current boyfriend of 5 years. The patient denies genitourinary symptoms. Her temperature is 98°F (36.7°C), blood pressure is 112/74 mmHg, pulse is 63/min, and respirations are 12/min with an oxygen saturation of 99% O2 on room air. Physical examination, including a pelvic exam, shows no abnormalities. The patient is worried because she is back in graduate school and cannot afford another child. Which of the following is the most effective emergency contraception?
Q92
A 37-year-old woman, gravida 3, para 3, comes to the physician for a follow-up examination. She gave birth to her third child 8 months ago and now wishes to start a contraception method. Prior to her most recent pregnancy, she used a combined estrogen-progestin pill. Which of the following aspects of her history would be a contraindication for restarting an oral contraceptive pill?
Q93
A 22-year-old woman comes to the physician because of a 1-week history of nausea and vomiting. She has not had fever, abdominal pain, diarrhea, or vaginal bleeding. She does not remember the date of her last menstrual period. She uses oral contraceptive pills but occasionally forgot to take them. She had pelvic inflammatory disease 2 years ago and was treated with antibiotics. Her temperature is 37°C (98.6°F), pulse is 110/min, respirations are 16/min, and blood pressure is 118/75 mm Hg. Physical examination shows no abnormalities. Pelvic examination shows a normal appearing vagina, cervix, uterus, and adnexa. A urine pregnancy test is positive. Her serum β-human chorionic gonadotropin concentration is 805 mIU/mL. Which of the following is the most appropriate next step in diagnosis?
Q94
A healthy 31-year-old woman comes to the physician because she is trying to conceive. She is currently timing the frequency of intercourse with at-home ovulation test kits. An increase in the levels of which of the following is the best indicator that ovulation has occurred?
Q95
A 17-year-old girl comes to your outpatient clinic. She is sexually active with multiple partners and requests a prescription for oral contraceptive pills. A urine pregnancy test in your office is negative. Which of the following is the most appropriate next step?
Q96
A 28-year-old woman, gravida 1, para 0, at 10 weeks' gestation comes to the physician for her initial prenatal visit. She has no history of serious illness, but reports that she is allergic to penicillin. Vital signs are within normal limits. The lungs are clear to auscultation, and cardiac examination shows no abnormalities. Transvaginal ultrasonography shows an intrauterine pregnancy with no abnormalities. The fetal heart rate is 174/min. Routine prenatal laboratory tests are drawn. Rapid plasma reagin (RPR) test is 1:128 and fluorescent treponemal antibody absorption test (FTA-ABS) is positive. Which of the following is the most appropriate next step in management?
Q97
A 24-year-old G1P0000 presents for her first obstetric visit and is found to be at approximately 8 weeks gestation. She has no complaints aside from increased fatigue and occasional nausea. The patient is a recent immigrant from Africa and is currently working as a babysitter for several neighborhood children. One of them recently had the flu, and another is home sick with chickenpox. The patient has no immunization records and does not recall if she has had any vaccinations. She is sexually active with only her husband, has never had a sexually transmitted disease, and denies intravenous drug use. Her husband has no past medical history. Exam at this visit is unremarkable. Her temperature is 98.7°F (37.1°C), blood pressure is 122/76 mmHg, pulse is 66/min, and respirations are 12/min. Which of the following immunizations should this patient receive at this time?
Q98
A 27-year-old woman, gravida 2, para 1, at 32 weeks' gestation comes to the physician for a prenatal visit. She feels that her baby's movements have decreased recently. She says that she used to feel 10–12 movements/hour earlier, but that it has recently decreased to about 7–8/hour. Pregnancy and delivery of her first child were uncomplicated. Medications include folic acid and a multivitamin. Her temperature is 37.2°C (99°F), and blood pressure is 108/60 mm Hg. Pelvic examination shows a uterus consistent in size with a 32-week gestation. The fetus is in a transverse lie presentation. The fetal heart rate is 134/min. A 14-minute recording of the nonstress test is shown. Which of the following is the most appropriate next step in managing this patient?
Q99
A 36-year-old woman presents with a whitish vaginal discharge over the last week. She also complains of itching and discomfort around her genitals. She says her symptoms are getting progressively worse. She has been changing her undergarments frequently and changed the brand of detergent she uses to wash her clothes, but it did not resolve her problem. Additionally, she admits to having painful urination and increased urinary frequency for the past one month, which she was told are expected side effects of her medication. The patient denies any recent history of fever or malaise. She has 2 children, both delivered via cesarean section in her late twenties. Past medical history is significant for hypertension and diabetes mellitus type 2. Current medications are atorvastatin, captopril, metformin, and empagliflozin. Her medications were changed one month ago to improve her glycemic control, as her HbA1c at that time was 7.5%. Her vital signs are a blood pressure of 126/84 mm Hg and a pulse of 78/min. Her fingerstick glucose is 108 mg/dL. Pelvic examination reveals erythema and mild edema of the vulva. A thick, white, clumpy vaginal discharge is seen. The vaginal pH is 4.0. Microscopic examination of a KOH-treated sample of the discharge demonstrates lysis of normal cellular elements with branching pseudohyphae. Which of the following is the next best step in the management of this patient?
Q100
A 23-year-old woman presented to the clinic for her first prenatal appointment with fatigue and pain in the perineum for the past 8 days. The past medical history is benign and she claimed to have only had unprotected intercourse with her husband. She had a documented allergic reaction to amoxicillin 2 years ago. The vaginal speculum exam revealed a clean, ulcerated genital lesion, which was tender and non-exudative. No lymphadenopathy was detected. A rapid plasma reagin (RPR) test revealed a titer of 1:64 and the fluorescent treponemal antibody absorption (FTA- abs) test was positive. What is the next best step in the management of this patient?
Prenatal Care US Medical PG Practice Questions and MCQs
Question 91: A 22-year-old G1P1 woman comes to the clinic asking about “the morning after pill.” She reports that she had sexual intercourse with her boyfriend last night and she thinks the condom broke. She is not using any other form of contraception. She reports her last menstrual period was 10 days ago, and they are normally regular. The patient’s medical history is significant for obesity, asthma and allergic rhinitis. Her medications include albuterol and occasional intranasal corticosteroids. She has no history of sexually transmitted diseases and is sexually active with only her current boyfriend of 5 years. The patient denies genitourinary symptoms. Her temperature is 98°F (36.7°C), blood pressure is 112/74 mmHg, pulse is 63/min, and respirations are 12/min with an oxygen saturation of 99% O2 on room air. Physical examination, including a pelvic exam, shows no abnormalities. The patient is worried because she is back in graduate school and cannot afford another child. Which of the following is the most effective emergency contraception?
A. Copper intrauterine device (Correct Answer)
B. Ulipristal pill
C. High-dose oral contraceptive therapy
D. Levonorgestrel-releasing intrauterine device
E. Levonorgestrel pill
Explanation: ***Copper intrauterine device***
- The **copper IUD** is the **most effective** form of emergency contraception, with a failure rate of less than 0.1%. It can be inserted up to 5 days after unprotected intercourse.
- It works by creating a **spermicidal inflammatory reaction** in the uterus, preventing fertilization and implantation. It also offers long-term contraception.
*Ulipristal pill*
- The **ulipristal pill** is an effective oral emergency contraceptive, but it is **less effective** than the copper IUD, with a failure rate of 1.3-1.6%.
- It is a **selective progesterone receptor modulator** that delays or inhibits ovulation and can be taken up to 5 days after unprotected intercourse.
*High-dose oral contraceptive therapy*
- This method (the **Yuzpe regimen**) involves taking multiple doses of combined estrogen-progestin pills. It is **less effective** than ulipristal or levonorgestrel pills, with a failure rate higher than 2%.
- It works by disrupting the **ovulatory cycle**. Its use has declined due to higher rates of side effects like nausea and vomiting.
*Levonorgestrel-releasing intrauterine device*
- The **levonorgestrel-releasing IUD** is **not approved or recommended** for emergency contraception. Its primary use is for long-term contraception.
- While it can prevent pregnancy, there is **insufficient evidence** to support its efficacy as an emergency contraceptive compared to the copper IUD.
*Levonorgestrel pill*
- The **levonorgestrel pill** (e.g., Plan B One-Step) is an oral emergency contraceptive that is **less effective** than the copper IUD or ulipristal. Its efficacy decreases beyond 72 hours and for individuals with a higher BMI.
- It acts primarily by **inhibiting or delaying ovulation**. It is ineffective if ovulation has already occurred.
Question 92: A 37-year-old woman, gravida 3, para 3, comes to the physician for a follow-up examination. She gave birth to her third child 8 months ago and now wishes to start a contraception method. Prior to her most recent pregnancy, she used a combined estrogen-progestin pill. Which of the following aspects of her history would be a contraindication for restarting an oral contraceptive pill?
A. She has recurrent migraine headaches without aura
B. Her hemoglobin A1c is 8.6%
C. She smokes 1 pack of cigarettes daily (Correct Answer)
D. Her infant is still breastfeeding
E. She has a history of cervical dysplasia
Explanation: ***She smokes 1 pack of cigarettes daily***
- **Smoking**, especially in women over 35, significantly increases the risk of **cardiovascular events** such as myocardial infarction and stroke, which is further exacerbated by the use of combined oral contraceptives (COCs).
- The **estrogen component** of COCs can promote a hypercoagulable state, making the combination with smoking particularly dangerous.
*She has recurrent migraine headaches without aura*
- **Migraine with aura** is a contraindication to combined oral contraceptives because it increases the risk of **ischemic stroke**.
- **Migraine without aura** is generally not a contraindication and is categorized as a U.S. Medical Eligibility Criteria for Contraceptive Use (US MEC) category 2, meaning the advantages generally outweigh the theoretical or proven risks.
*Her hemoglobin A1c is 8.6%*
- A **high HbA1c** indicates uncontrolled diabetes, which is a condition that, if accompanied by vascular disease or of >20 years' duration, would be a contraindication to COCs.
- However, in the absence of **vascular complications**, diabetes itself (even uncontrolled) is not an absolute contraindication to COCs, but rather a US MEC category 3 (risks generally outweigh advantages).
*Her infant is still breastfeeding*
- While combined oral contraceptives can **reduce milk supply** and alter milk composition, particularly if initiated before 6 weeks postpartum, they are not an absolute contraindication, especially after 6 months.
- **Progestin-only pills** are generally preferred for breastfeeding mothers due to their minimal impact on lactation.
*She has a history of cervical dysplasia*
- There is no evidence suggesting that oral contraceptive use is contraindicated in women with a history of **cervical dysplasia**.
- Current guidelines do not list cervical dysplasia as a condition that would preclude the use of combined oral contraceptives.
Question 93: A 22-year-old woman comes to the physician because of a 1-week history of nausea and vomiting. She has not had fever, abdominal pain, diarrhea, or vaginal bleeding. She does not remember the date of her last menstrual period. She uses oral contraceptive pills but occasionally forgot to take them. She had pelvic inflammatory disease 2 years ago and was treated with antibiotics. Her temperature is 37°C (98.6°F), pulse is 110/min, respirations are 16/min, and blood pressure is 118/75 mm Hg. Physical examination shows no abnormalities. Pelvic examination shows a normal appearing vagina, cervix, uterus, and adnexa. A urine pregnancy test is positive. Her serum β-human chorionic gonadotropin concentration is 805 mIU/mL. Which of the following is the most appropriate next step in diagnosis?
A. Administer methotrexate now
B. Schedule dilation and evacuation
C. Transvaginal ultrasound in 4 days (Correct Answer)
D. Diagnostic laparoscopy now
E. Administer misoprostol now
Explanation: ***Transvaginal ultrasound in 4 days***
- A serum β-hCG level of 805 mIU/mL is below the **discriminatory zone** (1500-2000 mIU/mL) where an intrauterine pregnancy should be visible on transvaginal ultrasound. Repeating the ultrasound in a few days will allow the β-hCG level to rise, potentially past the discriminatory zone, and confirm the location of the pregnancy.
- The patient has risk factors for **ectopic pregnancy** (history of PID, occasional missed OCPs indicating potential conception despite contraception), making it crucial to determine pregnancy location. However, immediate intervention is not indicated given her stable vitals and low β-hCG.
*Administer methotrexate now*
- Methotrexate is used for ectopic pregnancies but only after **confirmation of an ectopic pregnancy** and consideration of gestational sac size and β-hCG levels, none of which are definitively known yet.
- Giving methotrexate prior to confirming diagnosis and stable vs. unstable presentation can be premature and potentially harmful if the pregnancy is intrauterine.
*Schedule dilation and evacuation*
- **Dilation and evacuation (D&E)** is a procedure for terminating an intrauterine pregnancy or removing retained products of conception.
- It is inappropriate without first determining the **location of the pregnancy** (intrauterine vs. ectopic) and confirming viability or non-viability.
*Diagnostic laparoscopy now*
- **Diagnostic laparoscopy** is an invasive surgical procedure used to diagnose and treat ectopic pregnancies, especially in unstable patients or when ultrasound is inconclusive.
- It is not indicated as a first step here because the patient is **hemodynamically stable**, and a less invasive diagnostic step (ultrasound) has not yet been optimally utilized.
*Administer misoprostol now*
- **Misoprostol** is used for medical abortion of intrauterine pregnancies or for cervical ripening.
- It is not appropriate at this stage as the **location and viability of the pregnancy are yet unknown**, and misoprostol would be ineffective or harmful in an undiagnosed ectopic pregnancy.
Question 94: A healthy 31-year-old woman comes to the physician because she is trying to conceive. She is currently timing the frequency of intercourse with at-home ovulation test kits. An increase in the levels of which of the following is the best indicator that ovulation has occurred?
A. Luteinizing hormone
B. Follicle stimulating hormone
C. Progesterone (Correct Answer)
D. Estrogen
E. Gonadotropin-releasing hormone
Explanation: ***Progesterone***
- A sustained post-ovulatory rise in **progesterone** levels is the most reliable indicator that ovulation has occurred, as it is produced by the **corpus luteum** after the egg is released.
- Ovulation test kits detect the **LH surge** preceding ovulation, but a rise in progesterone confirms that ovulation actually took place.
*Luteinizing hormone*
- The **LH surge** is a key trigger for ovulation, but it indicates that ovulation is *about to occur*, not that it has already taken place.
- LH levels return to baseline shortly after the surge, making a sustained increase an unreliable indicator of *past* ovulation.
*Follicle stimulating hormone*
- **FSH** is primarily involved in the development of ovarian follicles and is high during the early follicular phase, declining before ovulation.
- While essential for follicle maturation, changes in FSH levels are not used to confirm that ovulation has occurred.
*Estrogen*
- **Estrogen** levels, particularly **estradiol**, peak just before the LH surge, indicating impending ovulation.
- After ovulation, estrogen levels initially decrease before a secondary rise during the luteal phase, making peak estrogen a sign before ovulation rather than confirmation of it.
*Gonadotropin-releasing hormone*
- **GnRH** is released in a pulsatile manner from the hypothalamus, stimulating the anterior pituitary to release FSH and LH.
- **GnRH** levels are difficult to measure directly and do not serve as a practical or direct indicator of ovulation itself.
Question 95: A 17-year-old girl comes to your outpatient clinic. She is sexually active with multiple partners and requests a prescription for oral contraceptive pills. A urine pregnancy test in your office is negative. Which of the following is the most appropriate next step?
A. Recommend sexually-transmitted infection screening and provide the requested prescription (Correct Answer)
B. Perform urine drug screen
C. Refer the patient for counseling and recommend sexually-transmitted infection screening
D. Contact the patient's parents to obtain consent
E. Advise against oral contraceptive medications and recommend condom use instead
Explanation: ***Recommend sexually-transmitted infection screening and provide the requested prescription***
- As a sexually active adolescent with multiple partners, **STI screening** is crucial for preventing negative health outcomes.
- Providing **oral contraceptive pills** empowers the patient to make informed decisions about her reproductive health, especially after a negative pregnancy test.
*Perform urine drug screen*
- There is **no clinical indication** presented in the scenario to suggest drug use, making a drug screen inappropriate.
- Performing a drug screen without cause could **damage trust** and is **not relevant** to her request for contraception.
*Refer the patient for counseling and recommend sexually-transmitted infection screening*
- While STI screening is appropriate, **referring for counseling without specific indication** may be perceived as judgmental and is not the most immediate next step.
- The physician can provide initial counseling regarding **safe sexual practices** in the same visit.
*Contact the patient's parents to obtain consent*
- In many jurisdictions, adolescents have the right to **confidential access to reproductive healthcare**, including contraception, without parental consent.
- Contacting parents could **violate confidentiality** and deter the patient from seeking necessary care in the future.
*Advise against oral contraceptive medications and recommend condom use instead*
- While condom use is important for STI prevention and can be used for contraception, **oral contraceptive pills offer a highly effective method** of pregnancy prevention.
- **Both methods can be discussed**, but advising against oral contraceptives outright disrespects the patient's request and limits her choices for birth control.
Question 96: A 28-year-old woman, gravida 1, para 0, at 10 weeks' gestation comes to the physician for her initial prenatal visit. She has no history of serious illness, but reports that she is allergic to penicillin. Vital signs are within normal limits. The lungs are clear to auscultation, and cardiac examination shows no abnormalities. Transvaginal ultrasonography shows an intrauterine pregnancy with no abnormalities. The fetal heart rate is 174/min. Routine prenatal laboratory tests are drawn. Rapid plasma reagin (RPR) test is 1:128 and fluorescent treponemal antibody absorption test (FTA-ABS) is positive. Which of the following is the most appropriate next step in management?
A. Perform oral penicillin challenge test
B. Administer therapeutic dose of intramuscular penicillin G
C. Administer intravenous ceftriaxone
D. Administer oral azithromycin
E. Administer penicillin desensitization dose (Correct Answer)
Explanation: ***Administer penicillin desensitization dose***
- This patient has **syphilis** confirmed by positive RPR and FTA-ABS, and is pregnant with a reported penicillin allergy. **Penicillin** is the **only effective treatment** for **syphilis during pregnancy** that prevents congenital syphilis.
- Due to the critical need for penicillin and the reported allergy, **penicillin desensitization** is the most appropriate next step to allow for safe administration of the necessary treatment.
*Perform oral penicillin challenge test*
- An oral penicillin challenge test is used to **confirm or rule out a penicillin allergy** in non-urgent situations.
- This patient has confirmed syphilis in pregnancy, which requires **immediate treatment** with penicillin, making a challenge test too time-consuming and risky.
*Administer therapeutic dose of intramuscular penicillin G*
- Administering a full therapeutic dose of penicillin G directly without prior allergy evaluation or desensitization would be **dangerous** given her reported penicillin allergy.
- This could lead to a **severe allergic reaction**, such as anaphylaxis, which would be harmful to both the mother and the fetus.
*Administer intravenous ceftriaxone*
- Ceftriaxone is a **cephalosporin** and is effective against syphilis in non-pregnant patients. However, it is **not recommended for syphilis in pregnancy** due to its inability to adequately cross the placenta to treat fetal infection effectively.
- Additionally, there is a risk of **cross-reactivity** in patients with penicillin allergy, though usually lower than with other penicillins.
*Administer oral azithromycin*
- Azithromycin is an **alternative treatment for early syphilis** in non-pregnant individuals who are allergic to penicillin.
- However, **macrolides like azithromycin are not recommended in pregnancy** for syphilis treatment due to high rates of treatment failure and its inability to effectively prevent congenital syphilis.
Question 97: A 24-year-old G1P0000 presents for her first obstetric visit and is found to be at approximately 8 weeks gestation. She has no complaints aside from increased fatigue and occasional nausea. The patient is a recent immigrant from Africa and is currently working as a babysitter for several neighborhood children. One of them recently had the flu, and another is home sick with chickenpox. The patient has no immunization records and does not recall if she has had any vaccinations. She is sexually active with only her husband, has never had a sexually transmitted disease, and denies intravenous drug use. Her husband has no past medical history. Exam at this visit is unremarkable. Her temperature is 98.7°F (37.1°C), blood pressure is 122/76 mmHg, pulse is 66/min, and respirations are 12/min. Which of the following immunizations should this patient receive at this time?
A. Hepatitis B vaccine
B. Varicella vaccine
C. Intranasal flu vaccine
D. Tetanus/Diphtheria/Pertussis vaccine
E. Intramuscular flu vaccine (Correct Answer)
Explanation: ***Intramuscular flu vaccine***
- The **inactivated influenza vaccine** (intramuscular flu vaccine) is safe and recommended for all pregnant women, regardless of gestational age, during flu season.
- Given the patient's exposure to children, one of whom recently had the flu, vaccination is crucial for both maternal and fetal protection.
*Hepatitis B vaccine*
- While generally safe in pregnancy and recommended for at-risk individuals, there is no indication of high-risk behavior or exposure in this patient to warrant immediate vaccination during her first visit.
- Screening for **Hepatitis B surface antigen (HBsAg)** is a routine prenatal test, and vaccination decisions can be made based on those results or ongoing risk assessment.
*Varicella vaccine*
- The **varicella vaccine is a live attenuated vaccine** and is **contraindicated during pregnancy** due to the theoretical risk of congenital varicella syndrome.
- If indicated, it should be given postpartum.
*Intranasal flu vaccine*
- The **intranasal flu vaccine is a live attenuated vaccine** and is **contraindicated during pregnancy** due to the theoretical risk of transmitting a weakened live virus to the fetus.
- Only the inactivated injectable form of the flu vaccine is recommended for pregnant women.
*Tetanus/Diphtheria/Pertussis vaccine*
- The **Tdap vaccine** is recommended for all pregnant women, but it is typically administered between **27 and 36 weeks of gestation** to maximize antibody transfer to the fetus.
- Giving it at 8 weeks is premature for optimal passive immunity for the neonate.
Question 98: A 27-year-old woman, gravida 2, para 1, at 32 weeks' gestation comes to the physician for a prenatal visit. She feels that her baby's movements have decreased recently. She says that she used to feel 10–12 movements/hour earlier, but that it has recently decreased to about 7–8/hour. Pregnancy and delivery of her first child were uncomplicated. Medications include folic acid and a multivitamin. Her temperature is 37.2°C (99°F), and blood pressure is 108/60 mm Hg. Pelvic examination shows a uterus consistent in size with a 32-week gestation. The fetus is in a transverse lie presentation. The fetal heart rate is 134/min. A 14-minute recording of the nonstress test is shown. Which of the following is the most appropriate next step in managing this patient?
A. Perform vibroacoustic stimulation
B. Administer intravenous oxytocin
C. Repeat the nonstress test weekly
D. Extend the nonstress test by 20 minutes
E. Provide reassurance to the mother (Correct Answer)
Explanation: **Provide reassurance to the mother**
- The nonstress test (NST) shows a **reassuring fetal heart rate baseline (134 bpm)**, good variability, and **two accelerations of 15 bpm for 15 seconds** within 14 minutes, indicating a reactive NST.
- A **reactive NST**, even with perceived decreased fetal movements, suggests fetal well-being, lessening the need for further immediate interventions.
*Perform vibroacoustic stimulation*
- **Vibroacoustic stimulation** is typically used to elicit accelerations if the initial NST is non-reactive or inconclusive after a certain period of fetal monitoring.
- Since the NST is already reactive and reassuring, there is no immediate indication for **vibroacoustic stimulation**.
*Administer intravenous oxytocin*
- The administration of **intravenous oxytocin** is used for cervical ripening or induction of labor, or in a contraction stress test to assess uteroplacental function.
- It is not indicated as a primary response to decreased fetal movements with a **reassuring reactive NST**.
*Repeat the nonstress test weekly*
- While regular fetal monitoring is important in high-risk pregnancies, performing an NST weekly is typically a management strategy for **ongoing high-risk conditions** or non-reassuring findings.
- Given the current **reactive NST** and no other immediate risk factors besides subjective decreased movement, weekly NSTs are not immediately warranted as a next step.
*Extend the nonstress test by 20 minutes*
- Extending the NST is common practice if the initial tracing is **non-reactive or equivocal**, to allow more time for fetal activity and accelerations to occur.
- In this case, the NST is already **reactive within 14 minutes** (showing two accelerations), so extending it is unnecessary.
Question 99: A 36-year-old woman presents with a whitish vaginal discharge over the last week. She also complains of itching and discomfort around her genitals. She says her symptoms are getting progressively worse. She has been changing her undergarments frequently and changed the brand of detergent she uses to wash her clothes, but it did not resolve her problem. Additionally, she admits to having painful urination and increased urinary frequency for the past one month, which she was told are expected side effects of her medication. The patient denies any recent history of fever or malaise. She has 2 children, both delivered via cesarean section in her late twenties. Past medical history is significant for hypertension and diabetes mellitus type 2. Current medications are atorvastatin, captopril, metformin, and empagliflozin. Her medications were changed one month ago to improve her glycemic control, as her HbA1c at that time was 7.5%. Her vital signs are a blood pressure of 126/84 mm Hg and a pulse of 78/min. Her fingerstick glucose is 108 mg/dL. Pelvic examination reveals erythema and mild edema of the vulva. A thick, white, clumpy vaginal discharge is seen. The vaginal pH is 4.0. Microscopic examination of a KOH-treated sample of the discharge demonstrates lysis of normal cellular elements with branching pseudohyphae. Which of the following is the next best step in the management of this patient?
A. Start metronidazole.
B. Advise her to drink lots of cranberry juice.
C. Switch her from oral antidiabetic medication to insulin.
D. Start fluconazole. (Correct Answer)
E. Stop empagliflozin.
Explanation: **Start fluconazole.**
- The patient's symptoms (whitish, thick, clumpy vaginal discharge, itching, discomfort, vulvar erythema and edema, vaginal pH 4.0) combined with the microscopic finding of **branching pseudohyphae** (after KOH treatment) are classic for **vulvovaginal candidiasis (yeast infection).**
- **Fluconazole** is an antifungal medication commonly used to treat fungal infections, including candidiasis. Her use of empagliflozin, a SGLT2 inhibitor, which increases glucose excretion in urine, is a predisposing factor for both recurrent UTIs and yeast infections.
*Start metronidazole.*
- Metronidazole is an antibiotic used to treat bacterial vaginosis and trichomoniasis.
- The microscopic finding of **pseudohyphae** rules out bacterial vaginosis and trichomoniasis, making metronidazole an inappropriate choice here.
*Advise her to drink lots of cranberry juice.*
- Cranberry juice is often suggested for the prevention and symptomatic relief of urinary tract infections (UTIs).
- While the patient has some urinary symptoms (dysuria, frequency), the primary issue is symptomatic vaginal discharge with clear evidence of a fungal infection, for which cranberry juice is not a treatment.
*Switch her from oral antidiabetic medication to insulin.*
- The patient's current blood glucose (108 mg/dL) is well-controlled, and her HbA1c improved with the current medication regimen.
- While optimizing glycemic control is important, there is no immediate indication to switch to insulin, especially as her current regimen seems effective.
*Stop empagliflozin.*
- Empagliflozin, an SGLT2 inhibitor, increases glucosuria, which can predispose to genitourinary infections (UTIs and yeast infections).
- However, stopping the medication immediately might disrupt her glycemic control, which has recently improved. The best approach is to treat the infection first while continuing to manage her diabetes.
Question 100: A 23-year-old woman presented to the clinic for her first prenatal appointment with fatigue and pain in the perineum for the past 8 days. The past medical history is benign and she claimed to have only had unprotected intercourse with her husband. She had a documented allergic reaction to amoxicillin 2 years ago. The vaginal speculum exam revealed a clean, ulcerated genital lesion, which was tender and non-exudative. No lymphadenopathy was detected. A rapid plasma reagin (RPR) test revealed a titer of 1:64 and the fluorescent treponemal antibody absorption (FTA- abs) test was positive. What is the next best step in the management of this patient?
A. Doxycycline, 100 mg twice daily x 14 days
B. Parenteral ceftriaxone, 1 g x 10 days
C. Delay treatment until delivery
D. Penicillin desensitization, then intramuscular benzathine penicillin, G 2.4 million units (Correct Answer)
E. Oral tetracycline, 500 mg 4 times daily x 1 week
Explanation: ***Penicillin desensitization, then intramuscular benzathine penicillin, G 2.4 million units***
- This patient presents with primary syphilis (chancre, positive RPR 1:64, positive FTA-abs) and a **penicillin allergy**. **Benzathine penicillin G** is the only proven treatment for syphilis in pregnancy to prevent congenital syphilis.
- In pregnant patients with syphilis and a penicillin allergy, **desensitization to penicillin** is the recommended next step to allow for the administration of the appropriate treatment.
*Doxycycline, 100 mg twice daily x 14 days*
- **Doxycycline** is an effective treatment for primary syphilis in non-pregnant individuals.
- However, **tetracyclines are contraindicated in pregnancy** due to adverse effects on fetal bone and tooth development.
*Parenteral ceftriaxone, 1 g x 10 days*
- **Ceftriaxone** can be used as an alternative treatment for syphilis in non-pregnant individuals with penicillin allergy.
- However, its efficacy in **preventing congenital syphilis** is not fully established, making penicillin the preferred agent in pregnancy after desensitization.
*Delay treatment until delivery*
- Delaying treatment is **not appropriate** as it significantly increases the risk of **congenital syphilis**, leading to severe fetal morbidity and mortality.
- Treating syphilis during pregnancy is crucial for **preventing vertical transmission**.
*Oral tetracycline, 500 mg 4 times daily x 1 week*
- **Tetracycline** is an effective treatment for primary syphilis but is **contraindicated in pregnancy**.
- It poses a risk of **fetal tooth discoloration** and inhibition of bone growth.