Three days after delivery of a male newborn, a 36-year-old gravida 1, para 1 woman has fever and pain in her left leg. Pregnancy was complicated by premature rupture of membranes; the child was delivered at 35 weeks' gestation by lower segment transverse cesarean section because of a nonreassuring fetal heart rate. The patient has smoked half a pack of cigarettes daily for 5 years and continued to smoke during her pregnancy. Her temperature is 38.9°C (102°F), pulse is 110/min, and blood pressure is 110/80 mm Hg. Examination shows an edematous, erythematous, and warm left leg. Passive dorsiflexion of the left foot elicits pain in the calf. The peripheral pulses are palpated bilaterally. The uterus is nontender and palpated at the umbilicus. Ultrasonography of the left leg shows an incompressible left popliteal vein. Which of the following is the most appropriate initial step in management?
Q32
A 27-year-old woman, gravida 3, para 2, delivers twins via an uncomplicated vaginal delivery. Both placentas are delivered shortly afterward. The patient received regular prenatal care and experienced no issues during her pregnancy. Over the next hour, she continues to experience vaginal bleeding, with an estimated blood loss of 1150 mL. Vital signs are within normal limits. Physical exam shows an enlarged, soft uterus. Which of the following is the most appropriate next step in management?
Q33
A 31-year-old G6P6 woman with a history of fibroids gives birth to twins via vaginal delivery. Her pregnancy was uneventful, and she reported having good prenatal care. Both placentas are delivered immediately after the birth. The patient continues to bleed significantly over the next 20 minutes. Her temperature is 97.0°F (36.1°C), blood pressure is 124/84 mmHg, pulse is 95/min, respirations are 16/min, and oxygen saturation is 98% on room air. Continued vaginal bleeding is noted. Which of the following is the most appropriate initial step in management?
Q34
A 30-year-old gravida 2 para 2 presents to a medical clinic to discuss contraception options. She had a normal vaginal delivery of a healthy baby boy with no complications 2 weeks ago. She is currently doing well and is breastfeeding exclusively. She would like to initiate a contraceptive method other than an intrauterine device, which she tried a few years ago, but the intrauterine device made her uncomfortable. The medical history includes migraine headaches without aura, abnormal liver function with mild fibrosis, and epilepsy as a teenager. She sees multiple specialists due to her complicated history, but is stable and takes no medications. There is a history of breast cancer on the maternal side. On physical examination, the temperature is 36.5°C (97.7°F), the blood pressure is 150/95 mm Hg, the pulse is 89/min, and the respiratory rate is 16/min. After discussing the various contraceptive methods available, the patient decides to try combination oral contraceptive pills. Which of the following is an absolute contraindication to start the patient on combination oral contraceptive pills?
Q35
A 32-year-old woman, gravida 2, para 1, at 38 weeks' gestation is admitted to the hospital 30 minutes after spontaneous rupture of membranes. Her pregnancy has been complicated by gestational diabetes treated with insulin. Her first child was delivered vaginally. Her immunizations are up-to-date. She delivers the child via cesarean section without complications after failure to progress for 16 hours. Fourteen hours after birth, she reports having body aches and feeling warm. She has to change her perineal pad every 2–3 hours. She has abdominal cramping, especially when breastfeeding. She has voided her bladder four times since the birth. She appears uncomfortable. Her temperature is 37.9°C (100.2°F), pulse is 85/min, respirations are 18/min, and blood pressure is 115/60 mm Hg. The abdomen is soft, distended, and nontender. There is a healing transverse suprapubic incision without erythema or discharge. A firm, nontender uterine fundus is palpated at the level of the umbilicus. There is bright red blood on the perineal pad. The breasts are engorged and tender, without redness or palpable masses. Which of the following is the most appropriate next step in management?
Q36
A 24-year-old, gravida 1, para 1 woman develops lower abdominal pain and fevers 4 days after undergoing a cesarean delivery under general anesthesia for prolonged labor. Since delivery, she has had malodorous lochia and difficulty breastfeeding due to breast pain. She has not had any shortness of breath or chest pain. She received intravenous intrapartum penicillin for group B streptococcus prophylaxis, but does not take any other medications on a regular basis. She appears ill. Her temperature is 38.8°C (102°F), pulse is 120/min, respirations are 22/min, and blood pressure is 110/70 mm Hg. Examination shows a urinary catheter in place. Breasts are engorged and tender. Nipples are cracked with mild erythema. There is erythema surrounding a mildly tender, dry, low transverse, 12-cm incision in the lower abdomen. Pelvic examination shows dark-red, foul-smelling lochia and uterine tenderness. Her hemoglobin concentration is 9 g/dL, leukocyte count is 16,000/mm3, and platelet count is 300,000/mm3. Which of the following is the most likely cause of this patient's fever?
Q37
A 22-year-old G1P1 has an uncomplicated vaginal delivery and delivers a newborn boy at 39 + 1 weeks. The APGAR scores are 8 and 9 at 1 and 5 minutes, respectively. Shortly after the delivery, the child is put on his mother's chest for skin-to-skin and the mother is encouraged to initiate breastfeeding. Which of the following cells produces the hormone responsible for establishing lactation during this process?
Q38
A 29-year-old G2P2 female gives birth to a healthy baby boy at 39 weeks of gestation via vaginal delivery. Immediately after the delivery of the placenta, she experiences profuse vaginal hemorrhage. Her prior birthing history is notable for an emergency cesarean section during her first pregnancy. She did not receive any prenatal care during either pregnancy. Her past medical history is notable for obesity and diabetes mellitus, which is well controlled on metformin. Her temperature is 99.0°F (37.2°C), blood pressure is 95/50 mmHg, pulse is 125/min, and respirations are 22/min. On physical examination, the patient is in moderate distress. Her extremities are pale, cool, and clammy. Capillary refill is delayed. Which of the following is the most likely cause of this patient’s bleeding?
Q39
Immediately following prolonged delivery of the placenta at 40 weeks gestation, a 32-year-old multiparous woman develops vaginal bleeding. Other than mild asthma, the patient’s pregnancy has been uncomplicated. She has attended many prenatal appointments and followed the physician's advice about screening for diseases, laboratory testing, diet, and exercise. Previous pregnancies were uncomplicated. She has no history of a serious illness. She is currently on intravenous infusion of oxytocin. Her temperature is 37.2°C (99.0°F), blood pressure is 108/60 mm Hg, pulse is 88/min, and respirations are 17/min. Uterine palpation reveals a soft enlarged fundus that extends above the umbilicus. Based on the assessment of the birth canal and placenta, which of the following options is the most appropriate initial step in patient management?
Q40
A 38-year-old woman, gravida 2, para 2, is brought to the emergency department by her husband after an episode of unconsciousness. She delivered a healthy infant two weeks ago and the postpartum course was complicated by severe vaginal bleeding, for which she required 4 units of packed red blood cells. Since the blood transfusion, she has had decreased milk production and has felt fatigued. Her pulse is 118/min and blood pressure is 104/63 mm Hg. Her finger-stick glucose concentration is 34 mg/dL. Serum thyroid-stimulating hormone and thyroxine levels are low and the serum sodium level is 132 mEq/L. Which of the following is the most likely cause of this patient's condition?
Postpartum hemorrhage US Medical PG Practice Questions and MCQs
Question 31: Three days after delivery of a male newborn, a 36-year-old gravida 1, para 1 woman has fever and pain in her left leg. Pregnancy was complicated by premature rupture of membranes; the child was delivered at 35 weeks' gestation by lower segment transverse cesarean section because of a nonreassuring fetal heart rate. The patient has smoked half a pack of cigarettes daily for 5 years and continued to smoke during her pregnancy. Her temperature is 38.9°C (102°F), pulse is 110/min, and blood pressure is 110/80 mm Hg. Examination shows an edematous, erythematous, and warm left leg. Passive dorsiflexion of the left foot elicits pain in the calf. The peripheral pulses are palpated bilaterally. The uterus is nontender and palpated at the umbilicus. Ultrasonography of the left leg shows an incompressible left popliteal vein. Which of the following is the most appropriate initial step in management?
A. Graduated compression stockings
B. Urokinase
C. Low molecular weight heparin (Correct Answer)
D. Embolectomy
E. Warfarin
Explanation: ***Low molecular weight heparin***
- The patient's symptoms (leg pain, edema, erythema, warmth, positive Homan's sign), fever, and ultrasound findings of an **incompressible popliteal vein** are highly suggestive of **deep vein thrombosis (DVT)**, for which LMWH is the first-line treatment.
- She has several risk factors for DVT, including pregnancy/postpartum state, premature rupture of membranes, C-section, smoking, and fever (possibly indicating an underlying inflammatory state or infection).
*Graduated compression stockings*
- While compression stockings can be used as an adjunct to DVT treatment or for prevention, they are **not sufficient as a sole initial treatment** for an acute, symptomatic DVT confirmed by ultrasound.
- Their primary role is often in preventing post-thrombotic syndrome after adequate anticoagulation has been established or for prophylaxis in high-risk individuals.
*Urokinase*
- **Urokinase is a thrombolytic agent** used in specific, severe cases of DVT (e.g., iliofemoral DVT with limb-threatening ischemia or pulmonary embolism with hemodynamic instability) and carries a significant risk of bleeding.
- It is **not the initial management** for an uncomplicated DVT.
*Embolectomy*
- **Embolectomy (surgical removal of a clot)** is reserved for very severe cases of DVT or pulmonary embolism, especially when there is **limb ischemia** or life-threatening pulmonary embolism despite thrombolysis.
- It is an invasive procedure with higher risks and is not indicated as an initial step for this patient's presentation.
*Warfarin*
- **Warfarin is an oral anticoagulant** that is typically started after initial anticoagulation with heparin (either unfractionated or low molecular weight) has been established.
- It has a **delayed onset of action** (due to depletion of vitamin K-dependent clotting factors) and requires careful monitoring with INR, making it unsuitable for initial rapid anticoagulation in acute DVT.
Question 32: A 27-year-old woman, gravida 3, para 2, delivers twins via an uncomplicated vaginal delivery. Both placentas are delivered shortly afterward. The patient received regular prenatal care and experienced no issues during her pregnancy. Over the next hour, she continues to experience vaginal bleeding, with an estimated blood loss of 1150 mL. Vital signs are within normal limits. Physical exam shows an enlarged, soft uterus. Which of the following is the most appropriate next step in management?
A. Hysterectomy
B. Bimanual uterine massage (Correct Answer)
C. Methylergometrine
D. Tranexamic acid
E. Curettage with suctioning
Explanation: **Bimanual uterine massage**
- The enlarged, soft uterus and significant bleeding after delivery strongly suggest **uterine atony**, the most common cause of **postpartum hemorrhage (PPH)**.
- **Bimanual uterine massage** is the first-line and most appropriate initial step to stimulate uterine contractions and reduce bleeding by compressing blood vessels.
*Hysterectomy*
- **Hysterectomy** is a last resort surgical procedure for PPH, only considered after multiple less invasive measures have failed to control bleeding.
- It is too aggressive an intervention when conservative measures, like uterine massage and uterotonic medications, have not yet been attempted.
*Methylergometrine*
- **Methylergometrine** is a uterotonic medication used to treat uterine atony by promoting sustained uterine contractions.
- While appropriate for PPH, it should be administered *after* or *concurrently with* bimanual uterine massage, not as the very first step when the physical examination indicates a need for immediate manual intervention.
*Tranexamic acid*
- **Tranexamic acid** is an antifibrinolytic agent that helps stabilize clots and can be used as an adjunct in PPH.
- It is not a primary treatment for uterine atony and does not directly address the lack of uterine tone, which is the immediate cause of bleeding in this scenario.
*Curettage with suctioning*
- **Curettage with suctioning** is indicated for retained placental fragments or other intrauterine pathology causing hemorrhage.
- The prompt delivery of both placentas makes retained products unlikely, and the soft, enlarged uterus points to atony, not retained tissue.
Question 33: A 31-year-old G6P6 woman with a history of fibroids gives birth to twins via vaginal delivery. Her pregnancy was uneventful, and she reported having good prenatal care. Both placentas are delivered immediately after the birth. The patient continues to bleed significantly over the next 20 minutes. Her temperature is 97.0°F (36.1°C), blood pressure is 124/84 mmHg, pulse is 95/min, respirations are 16/min, and oxygen saturation is 98% on room air. Continued vaginal bleeding is noted. Which of the following is the most appropriate initial step in management?
A. Oxytocin
B. Blood product transfusion
C. Uterine artery embolization
D. Hysterectomy
E. Bimanual massage (Correct Answer)
Explanation: ***Bimanual massage***
- The patient is experiencing **postpartum hemorrhage (PPH)**, indicated by significant bleeding post-delivery. **Uterine atony** is the most common cause of PPH, and bimanual massage helps stimulate uterine contractions to reduce bleeding.
- This is a **first-line, non-pharmacological intervention** that can be rapidly initiated to manage uterine atony.
*Oxytocin*
- While **oxytocin** is a uterotonic agent used to treat PPH, the initial step is typically **bimanual massage** to physically stimulate the uterus while preparing for medication administration.
- Oxytocin infusion would be administered concurrent with or immediately following bimanual massage, but manual compression is often initiated first.
*Blood product transfusion*
- Blood product transfusion is indicated for significant blood loss and hemodynamic instability, but it is a **supportive measure** rather than an initial intervention to stop the bleeding.
- The patient's current **blood pressure (124/84 mmHg)** and **pulse (95/min)** do not immediately suggest severe hypovolemic shock requiring immediate transfusion as the *first* step before attempting to control the source of bleeding.
*Uterine artery embolization*
- **Uterine artery embolization** is a highly invasive procedure typically reserved for cases where conservative measures, including uterotonic agents and bimanual compression, have failed to control PPH.
- It is not an appropriate initial step, as it requires specialized equipment and personnel and would delay immediate management of active bleeding.
*Hysterectomy*
- **Hysterectomy** is a last-resort intervention for intractable PPH that cannot be controlled by all other methods, including uterotonics, uterine massage, and other surgical or interventional radiology techniques.
- It is a highly invasive procedure with significant morbidity and is not considered an initial management step.
Question 34: A 30-year-old gravida 2 para 2 presents to a medical clinic to discuss contraception options. She had a normal vaginal delivery of a healthy baby boy with no complications 2 weeks ago. She is currently doing well and is breastfeeding exclusively. She would like to initiate a contraceptive method other than an intrauterine device, which she tried a few years ago, but the intrauterine device made her uncomfortable. The medical history includes migraine headaches without aura, abnormal liver function with mild fibrosis, and epilepsy as a teenager. She sees multiple specialists due to her complicated history, but is stable and takes no medications. There is a history of breast cancer on the maternal side. On physical examination, the temperature is 36.5°C (97.7°F), the blood pressure is 150/95 mm Hg, the pulse is 89/min, and the respiratory rate is 16/min. After discussing the various contraceptive methods available, the patient decides to try combination oral contraceptive pills. Which of the following is an absolute contraindication to start the patient on combination oral contraceptive pills?
A. Mild liver fibrosis
B. Migraine headaches
C. Breastfeeding (Correct Answer)
D. History of epilepsy
E. Elevated blood pressure
Explanation: ***Breastfeeding***
- **Combination oral contraceptive pills (COCs)** contain estrogen, which can decrease **milk supply** and alter milk composition.
- Due to the potential impact on lactation and the passage of hormones into breast milk, COCs are generally **contraindicated for breastfeeding mothers**, especially in the first 6 weeks postpartum.
*Mild liver fibrosis*
- While significant active liver disease is a contraindication, **mild liver fibrosis** alone is generally not an absolute contraindication for COCs, especially if liver function is otherwise stable.
- The liver is involved in metabolizing hormones, but **mild fibrosis** typically does not impair this function to acontraindicating degree.
*Migraine headaches*
- **Migraines with aura** are an absolute contraindication for COCs due to an increased risk of stroke.
- However, **migraines without aura** are generally a relative contraindication (category 2 or 3 depending on age and other risk factors), meaning the benefits often outweigh the risks, and not an absolute contraindication.
*History of epilepsy*
- A history of **epilepsy** is generally not a contraindication for COCs themselves.
- Some antiepileptic medications can reduce the efficacy of COCs by inducing liver enzymes, but the COCs do not worsen epilepsy.
*Elevated blood pressure*
- Current **blood pressure of 150/95 mm Hg** (Stage 2 Hypertension) is a relative contraindication for COCs, particularly if not well-controlled.
- However, it is not an absolute contraindication if benefits outweigh risks and careful monitoring can be implemented; risks increase with uncontrolled severe hypertension.
Question 35: A 32-year-old woman, gravida 2, para 1, at 38 weeks' gestation is admitted to the hospital 30 minutes after spontaneous rupture of membranes. Her pregnancy has been complicated by gestational diabetes treated with insulin. Her first child was delivered vaginally. Her immunizations are up-to-date. She delivers the child via cesarean section without complications after failure to progress for 16 hours. Fourteen hours after birth, she reports having body aches and feeling warm. She has to change her perineal pad every 2–3 hours. She has abdominal cramping, especially when breastfeeding. She has voided her bladder four times since the birth. She appears uncomfortable. Her temperature is 37.9°C (100.2°F), pulse is 85/min, respirations are 18/min, and blood pressure is 115/60 mm Hg. The abdomen is soft, distended, and nontender. There is a healing transverse suprapubic incision without erythema or discharge. A firm, nontender uterine fundus is palpated at the level of the umbilicus. There is bright red blood on the perineal pad. The breasts are engorged and tender, without redness or palpable masses. Which of the following is the most appropriate next step in management?
A. Dilation and curettage
B. Observation
C. Pelvic ultrasound
D. Administration of intravenous clindamycin and gentamycin (Correct Answer)
E. Hysterectomy
Explanation: ***Administration of intravenous clindamycin and gentamycin***
- The patient's symptoms (fever, body aches, abdominal cramping, foul-smelling lochia implicitly suggested by perineal pad changes every 2-3 hours, 14 hours after C-section) are highly suggestive of **postpartum endometritis**.
- The first-line treatment for postpartum endometritis, especially after a **cesarean section**, is broad-spectrum intravenous antibiotics, typically a combination of **clindamycin and gentamicin**.
*Dilation and curettage*
- This procedure is typically reserved for cases of **retained placental fragments** causing postpartum hemorrhage or infection, which is not clearly indicated here.
- While retained products can cause similar symptoms, the initial treatment for presumed endometritis is antibiotics, especially given the history of C-section increasing infection risk.
*Observation*
- The patient presents with a **fever (37.9°C)**, systemic symptoms like body aches, and uterine tenderness (implied by cramping), which indicate an active infection requiring treatment.
- **Observation** alone would be inappropriate and could lead to progression of the infection and more severe complications.
*Pelvic ultrasound*
- While a pelvic ultrasound could rule out **retained placental fragments** or an abscess, it is not the initial management step for suspected postpartum endometritis.
- Antibiotic treatment should be initiated empirically based on clinical suspicion, and imaging can be considered if there is no improvement with antibiotics.
*Hysterectomy*
- **Hysterectomy** is an extreme measure reserved for severe, life-threatening postpartum infections that are unresponsive to aggressive medical management, such as a ruptured uterus or widespread necrosing infection.
- There is no indication for such an invasive procedure at this stage, as the patient's condition strongly suggests a treatable infection.
Question 36: A 24-year-old, gravida 1, para 1 woman develops lower abdominal pain and fevers 4 days after undergoing a cesarean delivery under general anesthesia for prolonged labor. Since delivery, she has had malodorous lochia and difficulty breastfeeding due to breast pain. She has not had any shortness of breath or chest pain. She received intravenous intrapartum penicillin for group B streptococcus prophylaxis, but does not take any other medications on a regular basis. She appears ill. Her temperature is 38.8°C (102°F), pulse is 120/min, respirations are 22/min, and blood pressure is 110/70 mm Hg. Examination shows a urinary catheter in place. Breasts are engorged and tender. Nipples are cracked with mild erythema. There is erythema surrounding a mildly tender, dry, low transverse, 12-cm incision in the lower abdomen. Pelvic examination shows dark-red, foul-smelling lochia and uterine tenderness. Her hemoglobin concentration is 9 g/dL, leukocyte count is 16,000/mm3, and platelet count is 300,000/mm3. Which of the following is the most likely cause of this patient's fever?
A. Normal postpartum fever
B. Pyelonephritis
C. Chorioamnionitis
D. Mastitis
E. Endometritis (Correct Answer)
Explanation: ***Endometritis***
- Postpartum fever, **lower abdominal pain**, **uterine tenderness**, and **malodorous lochia** occurring after a cesarean delivery are classic signs of **endometritis**.
- The patient's elevated **leukocyte count** and ill appearance further support a significant infection of the uterine lining.
*Normal postpartum fever*
- This patient's fever of 38.8°C (102°F) is sustained and accompanied by other concerning symptoms like **uterine tenderness**, **malodorous lochia**, and **leukocytosis**, which is beyond the scope of a mild, transient postpartum temperature elevation.
- Normal postpartum fever is usually transient, mild, and not associated with severe localizing symptoms or signs of infection.
*Pyelonephritis*
- While a **urinary catheter** is in place, increasing the risk of UTI, the primary symptoms of pyelonephritis (flank pain, dysuria) are absent.
- The dominant symptoms point to a uterine rather than urinary tract infection, specifically the **malodorous lochia** and **uterine tenderness**.
*Chorioamnionitis*
- **Chorioamnionitis** is an intraamniotic infection that occurs *during labor or before delivery*, often leading to **prolonged labor** and necessitating cesarean section.
- While the patient had prolonged labor and received intrapartum antibiotics, the development of fever and uterine findings **4 days postpartum** makes current chorioamnionitis unlikely; rather, it suggests a new postpartum infection.
*Mastitis*
- The patient has breast pain, engorgement, and cracked nipples, which are risk factors for **mastitis**.
- However, the most prominent and severe symptoms, including **lower abdominal pain**, **uterine tenderness**, and **malodorous lochia**, point away from mastitis as the *primary* cause of systemic illness and fever.
Question 37: A 22-year-old G1P1 has an uncomplicated vaginal delivery and delivers a newborn boy at 39 + 1 weeks. The APGAR scores are 8 and 9 at 1 and 5 minutes, respectively. Shortly after the delivery, the child is put on his mother's chest for skin-to-skin and the mother is encouraged to initiate breastfeeding. Which of the following cells produces the hormone responsible for establishing lactation during this process?
A. Lactotropes (Correct Answer)
B. Corticotropes
C. Thyrotropes
D. Somatotropes
E. Gonadotropes
Explanation: ***Lactotropes***
- **Lactotropes** are cells in the **anterior pituitary gland** that primarily produce and secrete **prolactin**, the hormone essential for initiating and maintaining lactation.
- The drop in **progesterone** and **estrogen** levels after placental delivery removes the inhibitory effect on prolactin, allowing it to stimulate milk production.
*Corticotropes*
- **Corticotropes** produce **adrenocorticotropic hormone (ACTH)**, which stimulates the adrenal cortex to secrete cortisol and other corticosteroids.
- While corticosteroids play a role in mammary gland development, ACTH is not directly responsible for establishing lactation.
*Thyrotropes*
- **Thyrotropes** produce **thyroid-stimulating hormone (TSH)**, which regulates the function of the thyroid gland.
- Thyroid hormones are important for overall metabolism and can influence general reproductive health, but they do not directly establish lactation.
*Somatotropes*
- **Somatotropes** produce **growth hormone (GH)**, which is involved in growth, metabolism, and cell reproduction.
- Although GH has some lactogenic properties and can act synergistically with prolactin, it is not the primary hormone responsible for establishing lactation.
*Gonadotropes*
- **Gonadotropes** produce **luteinizing hormone (LH)** and **follicle-stimulating hormone (FSH)**, which regulate the function of the ovaries and testes.
- These hormones are crucial for ovulation and ovarian steroid production, but they do not directly contribute to the establishment of lactation.
Question 38: A 29-year-old G2P2 female gives birth to a healthy baby boy at 39 weeks of gestation via vaginal delivery. Immediately after the delivery of the placenta, she experiences profuse vaginal hemorrhage. Her prior birthing history is notable for an emergency cesarean section during her first pregnancy. She did not receive any prenatal care during either pregnancy. Her past medical history is notable for obesity and diabetes mellitus, which is well controlled on metformin. Her temperature is 99.0°F (37.2°C), blood pressure is 95/50 mmHg, pulse is 125/min, and respirations are 22/min. On physical examination, the patient is in moderate distress. Her extremities are pale, cool, and clammy. Capillary refill is delayed. Which of the following is the most likely cause of this patient’s bleeding?
A. Chorionic villi invading into the myometrium
B. Placental implantation over internal cervical os
C. Chorionic villi attaching to the decidua basalis
D. Chorionic villi invading into the serosa
E. Chorionic villi attaching to the myometrium (Correct Answer)
Explanation: ***Chorionic villi attaching to the myometrium***
- This describes **placenta accreta**, where the **chorionic villi adhere directly to the myometrium** without invading beyond it. This condition is strongly associated with a history of **prior C-sections**, as the scar tissue increases the risk of abnormal placental implantation.
- The profuse hemorrhage immediately following placental delivery, despite the placenta being delivered, suggests a problem with normal placental separation from the uterine wall. **Placenta accreta** can lead to massive postpartum hemorrhage when the placenta attempts to separate, tearing the maternal vessels.
*Chorionic villi invading into the myometrium*
- This describes **placenta increta**, where the **chorionic villi invade deeper into the myometrium**. While also causing severe hemorrhage, the term "attaching to the myometrium" (accreta) is a more common and slightly less severe form often seen with prior C-sections.
- Both accreta and increta present similarly with hemorrhage, but accreta is the initial and most common form of abnormal adherence to the myometrium.
*Placental implantation over internal cervical os*
- This describes **placenta previa**, which is characterized by **painless vaginal bleeding** typically in the **second or third trimester**, before delivery.
- While a prior C-section is a risk factor for placenta previa, the hemorrhage in this case occurred *after* the delivery of the placenta, not before or during labor, ruling out active previa.
*Chorionic villi invading into the serosa*
- This describes **placenta percreta**, the most severe form where **chorionic villi invade through the myometrium and into the uterine serosa**, potentially involving adjacent organs.
- While it causes massive hemorrhage, "attaching to" or even "invading into" the myometrium (accreta/increta) are more probable, given the description, than invasion *through* to the serosa, though all are part of the placenta accreta spectrum.
*Chorionic villi invading beyond the serosa*
- This is an alternative description for **placenta percreta**, indicating invasion through the uterus and potentially into surrounding structures like the bladder.
- While this is a severe cause of postpartum hemorrhage, the provided option "Chorionic villi attaching to the myometrium" (placenta accreta) is the most common form of abnormally adherent placenta in the spectrum and is highly consistent with the patient's history of prior C-section and the clinical presentation of hemorrhage after placental delivery.
Question 39: Immediately following prolonged delivery of the placenta at 40 weeks gestation, a 32-year-old multiparous woman develops vaginal bleeding. Other than mild asthma, the patient’s pregnancy has been uncomplicated. She has attended many prenatal appointments and followed the physician's advice about screening for diseases, laboratory testing, diet, and exercise. Previous pregnancies were uncomplicated. She has no history of a serious illness. She is currently on intravenous infusion of oxytocin. Her temperature is 37.2°C (99.0°F), blood pressure is 108/60 mm Hg, pulse is 88/min, and respirations are 17/min. Uterine palpation reveals a soft enlarged fundus that extends above the umbilicus. Based on the assessment of the birth canal and placenta, which of the following options is the most appropriate initial step in patient management?
A. Intramuscular carboprost
B. Manual exploration of the uterus
C. Discontinuing oxytocin
D. Intravenous methylergonovine
E. Uterine fundal massage (Correct Answer)
Explanation: ***Uterine fundal massage***
- The patient presents with **postpartum hemorrhage** indicated by vaginal bleeding and a **soft, enlarged fundus** after placental delivery, suggesting **uterine atony**.
- **Uterine fundal massage** is the **first-line intervention** to encourage uterine contraction and reduce bleeding by expelling clots and compressing vessels.
*Intramuscular carboprost*
- **Carboprost** is a **prostaglandin F2 alpha analog** used to treat **uterine atony** when initial measures like uterine massage and oxytocin are insufficient.
- It is contraindicated in patients with **asthma** due to its bronchoconstrictive effects, which this patient has.
*Manual exploration of the uterus*
- **Manual exploration of the uterus** is indicated when there is suspicion of **retained placental fragments** or **uterine rupture**.
- While these can cause postpartum hemorrhage, the primary finding of a soft, boggy uterus points more strongly to atony, making massage the immediate priority.
*Discontinuing oxytocin*
- The patient is already on an **intravenous oxytocin infusion**, which is a uterotonic agent used to prevent and treat uterine atony.
- Discontinuing it would worsen **uterine atony** and increase blood loss, directly contradicting the goal of management.
*Intravenous methylergonovine*
- **Methylergonovine** is an **ergot alkaloid** used to treat **uterine atony**, but it is contraindicated in patients with **hypertension**, which is not explicitly present here, but it is a potent vasoconstrictor and second-line.
- It is often used as a **second-line agent** if oxytocin and massage are ineffective and there are no contraindications.
Question 40: A 38-year-old woman, gravida 2, para 2, is brought to the emergency department by her husband after an episode of unconsciousness. She delivered a healthy infant two weeks ago and the postpartum course was complicated by severe vaginal bleeding, for which she required 4 units of packed red blood cells. Since the blood transfusion, she has had decreased milk production and has felt fatigued. Her pulse is 118/min and blood pressure is 104/63 mm Hg. Her finger-stick glucose concentration is 34 mg/dL. Serum thyroid-stimulating hormone and thyroxine levels are low and the serum sodium level is 132 mEq/L. Which of the following is the most likely cause of this patient's condition?
A. Lactotrophic adenoma
B. Hypothalamic infarction
C. Pituitary ischemia (Correct Answer)
D. Postpartum thyroiditis
E. Adrenal hemorrhage
Explanation: ***Pituitary ischemia***
- This patient's symptoms are highly suggestive of **Sheehan syndrome**, which results from **ischemic necrosis of the pituitary gland** following massive postpartum hemorrhage. The **severe vaginal bleeding** and subsequent blood transfusion directly support this.
- The **decreased milk production (agalactia)** is due to lack of prolactin, **fatigue** and **low blood pressure** are consistent with adrenal insufficiency (due to ACTH deficiency), and **hypoglycemia** (finger-stick glucose 34 mg/dL), **low TSH and thyroxine** (hypothyroidism), and **hyponatremia** (serum sodium 132 mEq/L) all point to **panhypopituitarism**.
*Lactotrophic adenoma*
- A lactotrophic adenoma (prolactinoma) typically causes **hyperprolactinemia**, leading to **galactorrhea** (milk production outside of lactation) and menstrual irregularities, which is the opposite of this patient's decreased milk production.
- While it can cause headaches and visual field defects, it does not explain the widespread hormonal deficiencies such as hypothyroidism or adrenal insufficiency seen here.
*Hypothalamic infarction*
- Hypothalamic infarction could cause symptoms similar to pituitary dysfunction, as the hypothalamus regulates the pituitary. However, it is a much **rarer cause** of such a constellation of symptoms, especially in the context of recent postpartum hemorrhage.
- The direct connection between **postpartum hemorrhage** and pituitary ischemia makes Sheehan syndrome a more specific and likely diagnosis.
*Postpartum thyroiditis*
- Postpartum thyroiditis is characterized by inflammation of the thyroid gland after delivery, often presenting with a **transient hyperthyroid phase** followed by a hypothyroid phase.
- While it can cause fatigue and mood changes, it would not explain the **decreased milk production**, **hypoglycemia**, **low blood pressure**, or general multi-hormone deficiencies seen in this patient.
*Adrenal hemorrhage*
- Adrenal hemorrhage would lead to **primary adrenal insufficiency** (Addison's crisis), characterized by hypotension, hyponatremia, and hyperkalemia.
- While this patient has hypotension and hyponatremia consistent with adrenal insufficiency, adrenal hemorrhage **does not explain** the **decreased milk production** or the **central hypothyroidism** (low TSH and thyroxine) observed.