A 49-year-old woman comes to the office complaining of 2 weeks of urinary incontinence. She says she first noticed some light, urinary dribbling that would increase with sneezing or coughing. This dribble soon worsened, soaking through a pad every 3 hours. She denies any fevers, chills, abdominal pain, hematuria, dysuria, abnormal vaginal discharge, or increased urinary frequency. The patient had a bilateral tubal ligation 3 weeks ago. Her last menstrual period was 2 weeks ago. Her menses are regular and last 5 days. She has had 3 pregnancies that each resulted in uncomplicated, term vaginal deliveries. Her last pregnancy was 2 years ago. The patient has hypothyroidism and takes daily levothyroxine. She denies tobacco, alcohol, or illicit drug use. She has no history of sexually transmitted diseases. She is sexually active with her husband of 25 years. Her BMI is 26 kg/m^2. On physical examination, the abdomen is soft, nondistended, and nontender without palpable masses or hepatosplenomegaly. Rectal tone is normal. The uterus is anteverted, mobile, and nontender. There are no adnexal masses. Urine is seen pooling in the vaginal vault. Urinalysis is unremarkable. Which of the following is next best step in diagnosis?
Q12
A 30-year-old woman, gravida 4, para 3, at 39 weeks' gestation comes to the hospital 20 minutes after the onset of vaginal bleeding. She has not received prenatal care. Her third child was delivered by lower segment transverse cesarean section because of a footling breech presentation. Her other two children were delivered vaginally. Her temperature is 37.1°C (98.8°F), pulse is 86/min, respirations are 18/min, and blood pressure is 132/74 mm Hg. The abdomen is nontender, and no contractions are felt. The fetus is in a vertex presentation. The fetal heart rate is 96/min. Per speculum examination reveals ruptured membranes and severe bleeding from the external os. Which of the following is the most likely diagnosis?
Q13
A 32-year-old woman gravida 2, para 1, at 35 weeks' gestation is admitted to the hospital 1 hour after spontaneous rupture of membranes. She has had mild abdominal discomfort and nausea for a day. Her pregnancy has been complicated by gestational diabetes, which is controlled with a strict diet. Her first child was delivered by lower segment transverse cesarean section because of placental abruption. Current medications include iron and vitamin supplements. Her immunizations are up-to-date. Her temperature is 38.6°C (101.5°F), pulse is 122/min, and blood pressure is 110/78 mm Hg. Abdominal examination shows severe, diffuse tenderness throughout the lower quadrants. Speculum examination confirms rupture of membranes with drainage of malodorous, blood-tinged fluid. Ultrasonography shows the fetus in a cephalic presentation. The fetal heart rate is 175/min and reactive with no decelerations. Laboratory studies show:
Hemoglobin 11.1 g/dL
Leukocyte count 13,100/mm3
Serum
Na+ 136 mEq/L
Cl- 101 mEq/L
K+ 3.9 mEq/L
Glucose 108 mg/dL
Creatinine 1.1 mg/dL
Urine
Protein Negative
Glucose 1+
Blood Negative
WBC 3–4/hpf
RBC Negative
Nitrites Negative
Which of the following is the most likely diagnosis?
Q14
A 32-year-old female presents to her primary care provider with pelvic pain. She reports that for the last several years, she has had chronic pain that is worst just before her menstrual period. Over the past two months, she has also had worsening pain during intercourse. She denies dysuria, vaginal discharge, or vaginal pruritus. The patient has never been pregnant and previously used a copper intrauterine device (IUD) for contraception, but she had the IUD removed a year ago because it worsened her menorrhagia. She has now been using combined oral contraceptive pills (OCPs) for nearly a year. The patient reports improvement in her menorrhagia on the OCPs but denies any improvement in her pain. Her past medical history is otherwise unremarkable. Her temperature is 98.0°F (36.7°C), blood pressure is 124/73 mmHg, pulse is 68/min, and respirations are 12/min. The patient has tenderness to palpation during vaginal exam with lateral displacement of the cervix. A pelvic ultrasound shows no abnormalities, and a urine pregnancy test is negative. Which of the following is the best next step in management to confirm the diagnosis?
Q15
A previously healthy 25-year-old woman is brought to the emergency department because of a 1-hour history of sudden severe lower abdominal pain. The pain started shortly after having sexual intercourse. The pain is worse with movement and urination. The patient had several urinary tract infections as a child. She is sexually active with her boyfriend and uses condoms inconsistently. She cannot remember when her last menstrual period was. She appears uncomfortable and pale. Her temperature is 37.5°C (99.5°F), pulse is 110/min, and blood pressure is 90/60 mm Hg. Abdominal examination shows a palpable, tender right adnexal mass. Her hemoglobin concentration is 10 g/dL and her hematocrit is 30%. A urine pregnancy test is negative. Pelvic ultrasound shows a 5 x 3-cm right ovarian sac-like structure with surrounding echogenic fluid around the structure and the uterus. Which of the following is the most appropriate management for this patient's condition?
Q16
A 31-year-old G1P0 woman with a history of hypertension presents to the emergency department because she believes that she is in labor. She is in her 38th week of pregnancy and her course has thus far been uncomplicated. This morning, she began feeling painful contractions and noted vaginal bleeding after she fell off her bike while riding to work. She is experiencing lower abdominal and pelvic pain between contractions as well. Her temperature is 97.6°F (36.4°C), blood pressure is 177/99 mmHg, pulse is 100/min, respirations are 20/min, and oxygen saturation is 98% on room air. Physical exam is notable for a gravid and hypertonic uterus and moderate blood in the vaginal vault. Ultrasound reveals no abnormalities. Which of the following is the most likely diagnosis?
Q17
A 32-year-old female presents to the gynecologist with a primary concern of infertility. She has been unable to become pregnant over the last 16 months despite consistently trying with her husband. She has not used any form of contraception during this time and her husband has had a normal semen analysis. She has never been diagnosed with any chronic conditions that could explain her infertility; however, she remembers testing positive for a sexually transmitted infection about four years ago. Which of the following is the most likely cause for her infertility?
Q18
A 24-year-old woman, G1P0, presents to her OB/GYN for her annual examination with complaints of painful cramps, abdominal pressure, and bloating with her cycle. She reports that she has not menstruated since her missed abortion requiring dilatation and curettage (D&C) seven months ago. She is sexually active with her husband and is not using any form of contraception. Her BMI is 29. At the clinic, her vitals are as follows: temperature, 98.9°F; pulse, 80/min; and blood pressure, 120/70 mm Hg. The physical examination is unremarkable. Thyroid-stimulating hormone, follicle-stimulating hormone, and prolactin concentrations are all within normal limits. The patient tests negative for qualitative serum beta‐hCG. A progestin challenge test reveals no withdrawal bleeding. What is the most likely diagnosis?
Q19
A 30-year-old G3P0 woman who is 28 weeks pregnant presents for a prenatal care visit. She reports occasionally feeling her baby move but has not kept count over the past couple weeks. She denies any bleeding, loss of fluid, or contractions. Her previous pregnancies resulted in spontaneous abortions at 12 and 14 weeks. She works as a business executive, has been in excellent health, and has had no surgeries. She states that she hired a nutritionist and pregnancy coach to ensure good prospects for this pregnancy. On physical exam, fetal heart tones are not detected. Abdominal ultrasound shows a 24-week fetal demise. The patient requests an autopsy on the fetus and wishes for the fetus to pass "as naturally as possible." What is the best next step in management?
Q20
A 28-year-old primigravid woman at 36 weeks' gestation comes to the emergency department because of worsening pelvic pain for 2 hours. Three days ago, she had a burning sensation with urination that resolved spontaneously. She has nausea and has vomited fluid twice on her way to the hospital. She appears ill. Her temperature is 39.7°C (103.5°F), pulse is 125/min, respirations are 33/min, and blood pressure is 130/70 mm Hg. Abdominal examination shows diffuse tenderness. No contractions are felt. Speculum examination shows pooling of nonbloody, malodorous fluid in the vaginal vault. The cervix is not effaced or dilated. Laboratory studies show a hemoglobin concentration of 14 g/dL, a leukocyte count of 16,000/mm3, and a platelet count of 250,000/mm3. Fetal heart rate is 148/min and reactive with no decelerations. Which of the following is the most appropriate next step in management?
Labor Complications US Medical PG Practice Questions and MCQs
Question 11: A 49-year-old woman comes to the office complaining of 2 weeks of urinary incontinence. She says she first noticed some light, urinary dribbling that would increase with sneezing or coughing. This dribble soon worsened, soaking through a pad every 3 hours. She denies any fevers, chills, abdominal pain, hematuria, dysuria, abnormal vaginal discharge, or increased urinary frequency. The patient had a bilateral tubal ligation 3 weeks ago. Her last menstrual period was 2 weeks ago. Her menses are regular and last 5 days. She has had 3 pregnancies that each resulted in uncomplicated, term vaginal deliveries. Her last pregnancy was 2 years ago. The patient has hypothyroidism and takes daily levothyroxine. She denies tobacco, alcohol, or illicit drug use. She has no history of sexually transmitted diseases. She is sexually active with her husband of 25 years. Her BMI is 26 kg/m^2. On physical examination, the abdomen is soft, nondistended, and nontender without palpable masses or hepatosplenomegaly. Rectal tone is normal. The uterus is anteverted, mobile, and nontender. There are no adnexal masses. Urine is seen pooling in the vaginal vault. Urinalysis is unremarkable. Which of the following is next best step in diagnosis?
A. Q-tip test
B. Methylene blue instillation into the bladder (Correct Answer)
C. Transvaginal ultrasound
D. Cystoscopy
E. Post-void residual volume
Explanation: ***Methylene blue instillation into the bladder***
- The presence of **urine pooling in the vaginal vault** following a recent bilateral tubal ligation strongly suggests a **vesicovaginal fistula**, a direct communication between the bladder and vagina.
- Instilling methylene blue into the bladder and observing for its leakage into the vagina (via a vaginal tampon or speculum) is a definitive and minimally invasive test to confirm a vesicovaginal fistula.
*Q-tip test*
- The Q-tip test assesses **urethral hypermobility**, a common cause of stress urinary incontinence.
- While helpful for stress incontinence, it would not directly identify the source of urine pooling in the vaginal vault, especially after a recent gynecological procedure.
*Transvaginal ultrasound*
- A transvaginal ultrasound can visualize pelvic organs and assess for structural abnormalities, but it is **not the primary diagnostic test** for confirming a vesicovaginal fistula.
- While it might show fluid collections, it would not definitively distinguish urine from other fluids or pinpoint the exact fistula location as clearly as dye instillation.
*Cystoscopy*
- Cystoscopy allows direct visualization of the bladder lining and urethra, which can help identify the bladder opening of a fistula.
- However, performing dye instillation first is a simpler and less invasive method to confirm the presence of a fistula and often guides the subsequent cystoscopy for detailed evaluation.
*Post-void residual volume*
- Post-void residual volume measures the amount of urine left in the bladder after urination, which is useful in evaluating for **urinary retention** or **overflow incontinence**.
- This test would not directly diagnose a vesicovaginal fistula, as the patient is experiencing leakage rather than retention, and the pooling in the vaginal vault indicates an abnormal communication.
Question 12: A 30-year-old woman, gravida 4, para 3, at 39 weeks' gestation comes to the hospital 20 minutes after the onset of vaginal bleeding. She has not received prenatal care. Her third child was delivered by lower segment transverse cesarean section because of a footling breech presentation. Her other two children were delivered vaginally. Her temperature is 37.1°C (98.8°F), pulse is 86/min, respirations are 18/min, and blood pressure is 132/74 mm Hg. The abdomen is nontender, and no contractions are felt. The fetus is in a vertex presentation. The fetal heart rate is 96/min. Per speculum examination reveals ruptured membranes and severe bleeding from the external os. Which of the following is the most likely diagnosis?
A. Placenta accreta
B. Threatened abortion
C. Bloody show
D. Placenta previa
E. Ruptured vasa previa (Correct Answer)
Explanation: ***Ruptured vasa previa***
- The sudden onset of painless **vaginal bleeding** at 39 weeks with **fetal heart rate deceleration** (96/min) immediately after membrane rupture is highly indicative of vasa previa rupture.
- In vasa previa, fetal blood vessels lie within the membranes over the cervical os; rupture leads to rapid fetal blood loss.
*Placenta accreta*
- This condition involves abnormal adherence of the **placenta to the uterine wall** and usually presents with hemorrhage during the **third stage of labor** when the placenta fails to separate.
- While a previous cesarean section is a risk factor, the acute scenario with fetal distress following membrane rupture is less typical for placenta accreta as the primary cause of this specific bleeding episode.
*Threatened abortion*
- A threatened abortion occurs **before 20 weeks' gestation** and is characterized by vaginal bleeding with a closed cervix, and would not occur at 39 weeks' gestation.
- The symptoms presented by the patient, including being at term and having severe hemorrhage with fetal heart rate deceleration, are inconsistent with a threatened abortion.
*Bloody show*
- **Bloody show** is typically a small amount of blood-tinged mucus that occurs as the cervix begins to dilate and efface.
- It is not associated with severe, acute hemorrhage or immediate fetal distress, as seen in this case.
*Placenta previa*
- **Placenta previa** typically presents as painless vaginal bleeding in the late second or third trimester but usually does not cause acute, severe fetal heart rate deceleration unless there is significant maternal hypovolemia or placental abruption secondary to the previa.
- The sudden severe bleeding with a rapid drop in fetal heart rate after membrane rupture strongly points away from uncomplicated placenta previa and rather towards fetal vessel rupture.
Question 13: A 32-year-old woman gravida 2, para 1, at 35 weeks' gestation is admitted to the hospital 1 hour after spontaneous rupture of membranes. She has had mild abdominal discomfort and nausea for a day. Her pregnancy has been complicated by gestational diabetes, which is controlled with a strict diet. Her first child was delivered by lower segment transverse cesarean section because of placental abruption. Current medications include iron and vitamin supplements. Her immunizations are up-to-date. Her temperature is 38.6°C (101.5°F), pulse is 122/min, and blood pressure is 110/78 mm Hg. Abdominal examination shows severe, diffuse tenderness throughout the lower quadrants. Speculum examination confirms rupture of membranes with drainage of malodorous, blood-tinged fluid. Ultrasonography shows the fetus in a cephalic presentation. The fetal heart rate is 175/min and reactive with no decelerations. Laboratory studies show:
Hemoglobin 11.1 g/dL
Leukocyte count 13,100/mm3
Serum
Na+ 136 mEq/L
Cl- 101 mEq/L
K+ 3.9 mEq/L
Glucose 108 mg/dL
Creatinine 1.1 mg/dL
Urine
Protein Negative
Glucose 1+
Blood Negative
WBC 3–4/hpf
RBC Negative
Nitrites Negative
Which of the following is the most likely diagnosis?
A. Influenza
B. Acute appendicitis
C. Acute pyelonephritis
D. Uterine rupture
E. Chorioamnionitis (Correct Answer)
Explanation: ***Chorioamnionitis***
- This patient presents with **fever**, **maternal tachycardia**, **uterine tenderness**, and **malodorous, blood-tinged amniotic fluid** following rupture of membranes, which are classic signs of chorioamnionitis.
- The **fetal tachycardia** (175/min) and **maternal leukocytosis** (13,100/mm3) further support this diagnosis.
*Influenza*
- While influenza can cause fever and malaise, it typically presents with **respiratory symptoms** (e.g., cough, sore throat) which are absent in this case.
- It would not explain the specific obstetric findings such as **uterine tenderness** or **malodorous amniotic fluid**.
*Acute appendicitis*
- Although it can cause abdominal pain and nausea, **appendicitis** typically presents with pain localized to the **right lower quadrant**, often associated with rebound tenderness.
- **Malodorous amniotic fluid** and **fetal tachycardia** are not characteristic features of appendicitis.
*Acute pyelonephritis*
- Pyelonephritis would present with **costovertebral angle tenderness**, dysuria, and a urinalysis showing significant **leukocyturia** and bacteriuria, which are not seen here (WBCs 3-4/hpf, nitrites negative).
- The **diffuse lower quadrant tenderness** and malodorous amniotic fluid point away from a urinary tract infection as the primary diagnosis.
*Uterine rupture*
- Uterine rupture typically presents with **sudden, severe abdominal pain**, **fetal distress** (e.g., severe decelerations or bradycardia), and often a **palpable fetal part** in the abdomen due to extrusion.
- The fetal heart rate is reactive and 175/min, indicating **fetal tachycardia** rather than distress suggesting rupture, and the tenderness is diffuse rather than sudden and sharp with loss of uterine tone.
Question 14: A 32-year-old female presents to her primary care provider with pelvic pain. She reports that for the last several years, she has had chronic pain that is worst just before her menstrual period. Over the past two months, she has also had worsening pain during intercourse. She denies dysuria, vaginal discharge, or vaginal pruritus. The patient has never been pregnant and previously used a copper intrauterine device (IUD) for contraception, but she had the IUD removed a year ago because it worsened her menorrhagia. She has now been using combined oral contraceptive pills (OCPs) for nearly a year. The patient reports improvement in her menorrhagia on the OCPs but denies any improvement in her pain. Her past medical history is otherwise unremarkable. Her temperature is 98.0°F (36.7°C), blood pressure is 124/73 mmHg, pulse is 68/min, and respirations are 12/min. The patient has tenderness to palpation during vaginal exam with lateral displacement of the cervix. A pelvic ultrasound shows no abnormalities, and a urine pregnancy test is negative. Which of the following is the best next step in management to confirm the diagnosis?
A. Hysterosalpingogram
B. Hysteroscopy
C. Pelvic MRI
D. Laparoscopy (Correct Answer)
E. Abdominal ultrasound
Explanation: ***Laparoscopy***
- This patient's symptoms of **pelvic pain that worsens before menstruation**, **dyspareunia**, and **tenderness with lateral cervical displacement** are highly suggestive of **endometriosis**.
- **Laparoscopy with biopsy** is the gold standard for definitively diagnosing endometriosis, allowing for direct visualization and histological confirmation of endometrial implants.
*Hysterosalpingogram*
- A hysterosalpingogram is primarily used to evaluate **uterine cavity abnormalities** and **fallopian tube patency**, especially in the context of infertility.
- It would not be diagnostic for endometriosis, which involves endometrial tissue outside the uterus.
*Hysteroscopy*
- Hysteroscopy involves visualizing the **inside of the uterus** to diagnose and treat intrauterine conditions like polyps, fibroids, or adhesions.
- It would not detect endometrial implants located outside the uterine cavity, which is characteristic of endometriosis.
*Pelvic MRI*
- While pelvic MRI can identify larger endometrial implants or **endometriomas** (cysts on the ovaries), it is **not sensitive enough** to detect all forms of endometriosis, particularly superficial lesions.
- It is usually reserved for cases where deep infiltrating endometriosis is suspected or when surgical planning requires detailed anatomical information.
*Abdominal ultrasound*
- An abdominal ultrasound is less precise than a pelvic ultrasound and is generally **not used to evaluate gynecological conditions** like endometriosis.
- A **pelvic ultrasound** was already performed and found no abnormalities, which is common in endometriosis as many implants are too small to be seen with ultrasound.
Question 15: A previously healthy 25-year-old woman is brought to the emergency department because of a 1-hour history of sudden severe lower abdominal pain. The pain started shortly after having sexual intercourse. The pain is worse with movement and urination. The patient had several urinary tract infections as a child. She is sexually active with her boyfriend and uses condoms inconsistently. She cannot remember when her last menstrual period was. She appears uncomfortable and pale. Her temperature is 37.5°C (99.5°F), pulse is 110/min, and blood pressure is 90/60 mm Hg. Abdominal examination shows a palpable, tender right adnexal mass. Her hemoglobin concentration is 10 g/dL and her hematocrit is 30%. A urine pregnancy test is negative. Pelvic ultrasound shows a 5 x 3-cm right ovarian sac-like structure with surrounding echogenic fluid around the structure and the uterus. Which of the following is the most appropriate management for this patient's condition?
A. Intravenous methotrexate administration
B. Uterine artery embolization
C. Emergency exploratory laparotomy (Correct Answer)
D. Oral doxycycline and metronidazole administration
E. CT scan of the abdomen
Explanation: ***Emergency exploratory laparotomy***
- The patient presents with **sudden severe lower abdominal pain**, **hypotension (90/60 mm Hg)**, **tachycardia (110/min)**, **palpable tender right adnexal mass**, and signs of **anemia (Hb 10 g/dL, Hct 30%)**, along with **free fluid** on ultrasound, indicating **hemorrhagic shock due to a ruptured ectopic pregnancy or ovarian cyst**. This is a surgical emergency.
- An **exploratory laparotomy** is immediately indicated to identify the source of bleeding, control hemorrhage, and remove the ruptured structure, especially given her unstable vital signs.
*Intravenous methotrexate administration*
- **Methotrexate** is used for **unruptured ectopic pregnancies** with specific criteria (e.g., small size, stable patient, declining hCG levels), but it is contraindicated in cases of rupture due to the risk of hemorrhage.
- The patient's **hypotension** and **anemia** indicate active bleeding and hemodynamic instability, making medical management inappropriate and delaying critical surgical intervention.
*Uterine artery embolization*
- **Uterine artery embolization** is primarily used for conditions like **uterine fibroids** or **postpartum hemorrhage**.
- It is not the appropriate first-line emergency treatment for acute rupture of an ectopic pregnancy or ovarian cyst with hypovolemic shock.
*Oral doxycycline and metronidazole administration*
- **Doxycycline** and **metronidazole** are antibiotics used to treat **pelvic inflammatory disease (PID)**, which presents with symptoms like fever, vaginal discharge, and lower abdominal pain, but typically not acute hemorrhagic shock.
- This patient's presentation is an acute surgical emergency with signs of hemorrhage, not an infection requiring only antibiotic therapy.
*CT scan of the abdomen*
- While a **CT scan** could provide more detailed imaging, the patient's **hemodynamic instability** (hypotension, tachycardia) requires immediate intervention.
- Delaying definitive treatment for further imaging in acute hemorrhagic shock is not appropriate and could worsen her condition.
Question 16: A 31-year-old G1P0 woman with a history of hypertension presents to the emergency department because she believes that she is in labor. She is in her 38th week of pregnancy and her course has thus far been uncomplicated. This morning, she began feeling painful contractions and noted vaginal bleeding after she fell off her bike while riding to work. She is experiencing lower abdominal and pelvic pain between contractions as well. Her temperature is 97.6°F (36.4°C), blood pressure is 177/99 mmHg, pulse is 100/min, respirations are 20/min, and oxygen saturation is 98% on room air. Physical exam is notable for a gravid and hypertonic uterus and moderate blood in the vaginal vault. Ultrasound reveals no abnormalities. Which of the following is the most likely diagnosis?
A. Uterine rupture
B. Abruptio placentae (Correct Answer)
C. Placenta previa
D. Normal labor
E. Vasa previa
Explanation: ***Abruptio placentae***
- Vaginal bleeding after **trauma** (fall off bike), **hypertension**, and a **hypertonic uterus** with **lower abdominal/pelvic pain** between contractions are classic signs of placental abruption.
- Abruption occurs when the **placenta prematurely separates** from the uterine wall, leading to bleeding and uterine irritability.
*Uterine rupture*
- While uterine rupture involves abdominal pain and bleeding, it typically presents with **fetal distress**, **loss of uterine tone**, and a feeling of **'ripping'** or tearing, none of which are described.
- A uterine rupture is more common in women with a history of **prior C-section** or uterine surgery, which is not mentioned here.
*Placenta previa*
- Characterized by **painless vaginal bleeding** in the late second or third trimester, often with a soft, non-tender uterus.
- The presence of **painful contractions**, a **hypertonic uterus**, and a clear cause of trauma rules out placenta previa.
*Normal labor*
- While this patient is in labor, the presence of **significant vaginal bleeding**, **post-traumatic onset**, and **severe lower abdominal pain** between contractions are not typical for uncomplicated normal labor.
- Normal labor contractions are usually regular and progress, but the associated symptoms point to a more serious underlying issue.
*Vasa previa*
- Characterized by **fetal blood vessels** running within the membranes over the cervical os, leading to **painless vaginal bleeding** when these vessels rupture.
- This condition is often associated with **fetal distress** and **fetal hemorrhage**, which is not indicated here, and bleeding typically occurs upon rupture of membranes, not from trauma.
Question 17: A 32-year-old female presents to the gynecologist with a primary concern of infertility. She has been unable to become pregnant over the last 16 months despite consistently trying with her husband. She has not used any form of contraception during this time and her husband has had a normal semen analysis. She has never been diagnosed with any chronic conditions that could explain her infertility; however, she remembers testing positive for a sexually transmitted infection about four years ago. Which of the following is the most likely cause for her infertility?
A. Chlamydia serovars D-K (Correct Answer)
B. Chlamydia serovars A, B, or C
C. Chlamydia serovars L1, L2, or L3
D. Syphilis
E. Herpes simplex virus
Explanation: ***Chlamydia serovars D-K***
- **Chlamydia trachomatis serovars D-K** are the most common cause of **pelvic inflammatory disease (PID)**, which can lead to tubal scarring and infertility.
- The patient's history of a past STI and primary infertility despite normal male factors strongly suggests a sequela of **undiagnosed or inadequately treated chlamydial infection**.
*Chlamydia serovars A, B, or C*
- These serovars are primarily associated with **trachoma**, a chronic conjunctivitis that can cause blindness, especially in endemic regions.
- They are not typically linked to salpingitis or **female infertility**.
*Chlamydia serovars L1, L2, or L3*
- These serovars cause **lymphogranuloma venereum (LGV)**, which is characterized by invasive genital ulcers and regional lymphadenopathy.
- While LGV can cause chronic inflammation and scarring, it is less commonly implicated in **tubal factor infertility** than the D-K serovars.
*Syphilis*
- **Syphilis** is caused by *Treponema pallidum* and can lead to various complications, but it is not a direct cause of tubal damage or **female infertility**.
- Its effects on pregnancy are usually related to congenital syphilis or miscarriage, rather than an inability to conceive due to tubal issues.
*Herpes simplex virus*
- **Herpes simplex virus (HSV)** causes recurrent genital lesions and can be transmitted to a neonate, but it is not known to cause **tubal scarring** or **infertility** in women.
- The primary symptoms are painful genital ulcers, which do not typically affect tubal patency.
Question 18: A 24-year-old woman, G1P0, presents to her OB/GYN for her annual examination with complaints of painful cramps, abdominal pressure, and bloating with her cycle. She reports that she has not menstruated since her missed abortion requiring dilatation and curettage (D&C) seven months ago. She is sexually active with her husband and is not using any form of contraception. Her BMI is 29. At the clinic, her vitals are as follows: temperature, 98.9°F; pulse, 80/min; and blood pressure, 120/70 mm Hg. The physical examination is unremarkable. Thyroid-stimulating hormone, follicle-stimulating hormone, and prolactin concentrations are all within normal limits. The patient tests negative for qualitative serum beta‐hCG. A progestin challenge test reveals no withdrawal bleeding. What is the most likely diagnosis?
A. Pelvic inflammatory disease
B. Endometriosis
C. Hypothalamic hypoestrogenism
D. Ectopic pregnancy
E. Asherman syndrome (Correct Answer)
Explanation: ***Asherman syndrome***
- The patient's history of a missed abortion requiring **D&C** followed by secondary amenorrhea (no menstruation) and a negative **progestin challenge test** strongly suggests Asherman syndrome or **intrauterine adhesions**.
- The symptoms of painful cramps, abdominal pressure, and bloating without withdrawal bleeding are consistent with **endometrial scarring** preventing menstrual blood outflow.
*Pelvic inflammatory disease*
- This condition involves inflammation of the female upper genital tract, often presenting with **pelvic pain**, **fever**, and **vaginal discharge**, which are not reported here.
- While it can cause infertility and chronic pain, it typically doesn't lead to amenorrhea with a negative progestin challenge unless severe scarring blocks the uterus completely.
*Endometriosis*
- Endometriosis is characterized by the presence of **endometrial-like tissue outside the uterus**, causing **dysmenorrhea**, **chronic pelvic pain**, and **infertility**.
- While it explains painful cramps and bloating, it typically does not cause **amenorrhea** or a negative progestin challenge test.
*Hypothalamic hypoestrogenism*
- This condition results from **low estrogen levels** due to hypothalamic dysfunction, leading to amenorrhea, but a progestin challenge test would typically result in **withdrawal bleeding** if the endometrium is viable.
- The patient's normal FSH and prolactin levels, along with the specific history of D&C, make this less likely.
*Ectopic pregnancy*
- Ectopic pregnancy involves the implantation of a fertilized egg outside the uterus and would present with a **positive beta-hCG**, which is negative in this patient.
- Symptoms usually include **abdominal pain** and **vaginal bleeding** (or spotting), not prolonged amenorrhea following a D&C.
Question 19: A 30-year-old G3P0 woman who is 28 weeks pregnant presents for a prenatal care visit. She reports occasionally feeling her baby move but has not kept count over the past couple weeks. She denies any bleeding, loss of fluid, or contractions. Her previous pregnancies resulted in spontaneous abortions at 12 and 14 weeks. She works as a business executive, has been in excellent health, and has had no surgeries. She states that she hired a nutritionist and pregnancy coach to ensure good prospects for this pregnancy. On physical exam, fetal heart tones are not detected. Abdominal ultrasound shows a 24-week fetal demise. The patient requests an autopsy on the fetus and wishes for the fetus to pass "as naturally as possible." What is the best next step in management?
A. Induction of labor now (Correct Answer)
B. Dilation and evacuation
C. Dilation and curettage
D. Induction of labor at term
E. Caesarean delivery
Explanation: ***Induction of labor now***
- With a confirmed **fetal demise at 28 weeks**, induction of labor is the most appropriate and respectful approach, allowing the patient's request to pass "as naturally as possible" to be honored and initiating the grieving process.
- Delaying labor induction can lead to increased risks of **coagulopathy** (disseminated intravascular coagulation) due to retained fetal tissue, and also prolonged emotional distress for the patient.
*Dilation and evacuation*
- While D&E is a common method for second-trimester termination or fetal demise, it is typically performed earlier in pregnancy (up to 24 weeks) and may not align with the patient's wish for the fetus to pass "as naturally as possible" for a 28-week demise.
- Given the patient's strong emotional investment in this pregnancy and desire for an autopsy, a D&E might be perceived as less respectful or less natural than labor induction.
*Dilation and curettage*
- **Dilation and curettage (D&C)** is primarily used for first-trimester miscarriages or early second-trimester procedures and is not suitable for a 28-week fetal demise due to the size of the fetus.
- Performing a D&C at this gestational age would be technically difficult and carry a higher risk of complications, including uterine perforation.
*Induction of labor at term*
- Waiting until term for a known fetal demise at 28 weeks is medically inappropriate and dangerous due to the significant risk of **disseminated intravascular coagulation (DIC)** developing from retained fetal tissue.
- Prolonged retention of a deceased fetus also significantly increases the emotional and psychological burden on the patient.
*Caesarean delivery*
- **Caesarean delivery** is generally reserved for live births where there is a medical indication for surgical delivery or in cases of an intact dilation and extraction procedure which is not typically first line for fetal demise at this gestation.
- Performing a C-section for a fetal demise offers no benefit to the fetus and carries unnecessary surgical risks for the mother, including infection, hemorrhage, and complications in future pregnancies.
Question 20: A 28-year-old primigravid woman at 36 weeks' gestation comes to the emergency department because of worsening pelvic pain for 2 hours. Three days ago, she had a burning sensation with urination that resolved spontaneously. She has nausea and has vomited fluid twice on her way to the hospital. She appears ill. Her temperature is 39.7°C (103.5°F), pulse is 125/min, respirations are 33/min, and blood pressure is 130/70 mm Hg. Abdominal examination shows diffuse tenderness. No contractions are felt. Speculum examination shows pooling of nonbloody, malodorous fluid in the vaginal vault. The cervix is not effaced or dilated. Laboratory studies show a hemoglobin concentration of 14 g/dL, a leukocyte count of 16,000/mm3, and a platelet count of 250,000/mm3. Fetal heart rate is 148/min and reactive with no decelerations. Which of the following is the most appropriate next step in management?
A. Administer oral azithromycin and induce labor
B. Administer intravenous ampicillin and gentamicin and perform C-section
C. Administer intravenous ampicillin and gentamicin and induce labor (Correct Answer)
D. Perform C-section
E. Expectant management
Explanation: ***Administer intravenous ampicillin and gentamicin and induce labor***
- This patient presents with signs of **chorioamnionitis** (fever, maternal tachycardia, uterine tenderness, malodorous amniotic fluid with ruptured membranes), necessitating immediate broad-spectrum antibiotics and delivery.
- **Induction of labor** is generally preferred over C-section for chorioamnionitis unless there are other obstetric indications for C-section, to minimize maternal morbidity and reduce overall fetal exposure to infection.
*Administer oral azithromycin and induce labor*
- **Oral azithromycin** is not appropriate for the acute management of chorioamnionitis, which requires broad-spectrum intravenous antibiotics due to the potential for severe maternal and fetal infection.
- While **induction of labor** is correct, the choice of antibiotic is inadequate for this severe infection
*Administer intravenous ampicillin and gentamicin and perform C-section*
- While **intravenous ampicillin and gentamicin** are appropriate antibiotics for chorioamnionitis, a **C-section** is not the standard primary management unless there's a specific obstetric indication (e.g., failed induction, fetal distress).
- Vaginal delivery is generally safer for the mother in cases of chorioamnionitis, as C-section increases the risk of **postpartum endometritis** and wound infection.
*Perform C-section*
- **C-section** alone without immediate antibiotic treatment would be inappropriate and dangerous given the active infection.
- A C-section is also not the first-line delivery method for chorioamnionitis unless other complications necessitate it.
*Expectant management*
- **Expectant management** is contraindicated in chorioamnionitis due to the high risk of severe maternal and neonatal morbidity and mortality, including **sepsis**.
- Immediate intervention with antibiotics and delivery is crucial to prevent further progression of the infection.