A 23-year-old woman comes to the emergency department because of increasing abdominal pain with associated nausea and vomiting. The symptoms began suddenly after having intercourse with her partner six hours ago. There is no associated fever, diarrhea, vaginal bleeding, or discharge. Menarche was at the age of 13 years and her last menstrual period was 4 weeks ago. She uses combination contraceptive pills. She had an appendectomy at the age of 12. Her temperature is 37.5°C (99.5°F), pulse is 100/min, respirations are 22/min, and blood pressure is 110/70 mm Hg. Abdominal examination shows severe right lower quadrant tenderness with associated rebound and guarding. Pelvic examination shows scant, clear vaginal discharge and right adnexal tenderness. There is no cervical wall motion tenderness. Her hemoglobin concentration is 10.5 g/dL, leukocyte count is 9,000/mm3, and platelet count is 250,000/mm3. A urine pregnancy test is negative. Which of the following imaging findings is most likely?
Q92
A 66-year-old G3P3 presents with an 8-year-history of back pain, perineal discomfort, difficulty urinating, recurrent malaise, and low-grade fevers. These symptoms have recurred regularly for the past 5–6 years. She also says that there are times when she experiences a feeling of having a foreign body in her vagina. With the onset of symptoms, she was evaluated by a physician who prescribed her medications after a thorough examination and recommended a vaginal pessary, but she was non-compliant. She had 3 vaginal deliveries She has been menopausal since 51 years of age. She does not have a history of malignancies or cardiovascular disease. She has type 2 diabetes mellitus that is controlled with diet and metformin. Her vital signs include: blood pressure 110/60 mm Hg, heart rate 91/min, respiratory rate 13/min, and temperature 37.4℃ (99.3℉). On physical examination, there is bilateral costovertebral angle tenderness. The urinary bladder is non-palpable. The gynecologic examination reveals descent of the cervix to the level of the introitus. A Valsalva maneuver elicits uterine procidentia. Which pathology is most likely to be revealed by imaging in this patient?
Q93
A previously healthy 28-year-old woman comes to the physician because of lower abdominal pain and purulent vaginal discharge for the past 5 days. Menses occur at irregular 20 to 40-day intervals and last 4 to 8 days. She is sexually active with a new partner that she met 2 months ago and they use condoms inconsistently. She had a normal pap smear 5 months ago. She drinks 2 beers every other day. Her temperature is 39°C (102.2°F), pulse is 85/min, and blood pressure is 108/75 mm Hg. Examination shows lower abdominal tenderness and bilateral inguinal lymphadenopathy. Pelvic examination is notable for uterine and adnexal tenderness as well as small amounts of bloody cervical discharge. A spot urine pregnancy test is negative. Laboratory studies show a leukocyte count of 14,500/mm3 and an erythrocyte sedimentation rate of 90 mm/h. Nucleic acid amplification confirms the suspected diagnosis. The patient is started on ceftriaxone and doxycycline. Which of the following is the most appropriate next step in management?
Q94
A 72-year-old multiparous woman comes to the physician for the evaluation of episodes of involuntary urine leakage for the past 6 months. She loses small amounts of urine without warning after laughing or sneezing. She also sometimes forgets the names of her grandchildren and friends. She is retired and lives at an assisted-living facility. She has insulin-dependent diabetes mellitus type 2. Her mother received a ventriculoperitoneal shunt around her age. She walks without any problems. Sensation to pinprick and light touch is normal. Which of the following is the primary underlying etiology for this patient's urinary incontinence?
Q95
A 29-year-old woman, gravida 1, para 0, at 38 weeks' gestation comes to the emergency department for sudden leakage of clear fluid from her vagina. Her pregnancy has been uncomplicated. She has largely been compliant with her prenatal care but missed some appointments. She has a history of chronic hypertension. She drinks a glass of wine once per week. Current medications include labetalol, iron, and vitamin supplements. Her temperature is 37.9°C (100.2°F), pulse is 70/min, respirations are 18/min, and blood pressure is 128/82 mm Hg. Examination shows a soft and nontender abdomen on palpation. Speculum examination demonstrates clear fluid in the cervical canal. The fetal heart rate is reactive at 170/min with no decelerations. Tocometry shows no contractions. The vaginal fluid demonstrates a ferning pattern when placed onto a glass slide. Which of the following is the most likely cause of this patient's condition?
Q96
A 36-year-old primigravid woman at 26 weeks' gestation comes to the physician complaining of absent fetal movements for the last 2 days. Pregnancy was confirmed by ultrasonography 14 weeks earlier. She has no vaginal bleeding or discharge. She has a history of type 1 diabetes mellitus controlled with insulin. Vital signs are all within the normal limits. Pelvic examination shows a soft, 2-cm long cervix in the midline with a cervical os measuring 3 cm and a uterus consistent in size with 24 weeks' gestation. Transvaginal ultrasonography shows a fetus with no cardiac activity. Which of the following is the most appropriate next step in management?
Q97
A 35-year-old G1 is brought to the emergency department because of sharp pains in her abdomen. She is at 30 weeks gestation based on ultrasound. She complains of feeling a little uneasy during the last 3 weeks of her pregnancy. She mentions that her abdomen has not been enlarging as expected and her baby is not moving as much as during the earlier part of the pregnancy. If anything, she noticed her abdomen has decreased in size. While she is giving her history, the emergency medicine physician notices that she is restless and is sweating profusely. An ultrasound is performed and her blood is sent for type and match. The blood pressure is 90/60 mm Hg, the pulse is 120/min, and the respiratory rate is 18/min. The fetal ultrasound is significant for no fetal heart motion or fetal movement. Her blood work shows the following: hemoglobin, 10.3 g/dL; platelet count, 1.1*10(5)/ml; bleeding time, 10 minutes; PT, 25 seconds; and PTT, 45 seconds. Which of the following would be the best immediate course of management for this patient?
Q98
A 17-year-old girl comes to the emergency department with a 5-day history of severe abdominal pain, cramping, nausea, and vomiting. She also has pain with urination. She is sexually active with one male partner, and they use condoms inconsistently. She experienced a burning pain when she last had sexual intercourse 3 days ago. Menses occur at regular 28-day intervals and last 5 days. Her last menstrual period was 3 weeks ago. Her temperature is 38.5°C (101.3°F), pulse is 83/min, and blood pressure is 110/70 mm Hg. Physical examination shows abdominal tenderness in the lower quadrants. Pelvic examination shows cervical motion tenderness and purulent cervical discharge. Laboratory studies show a leukocyte count of 15,000/mm3 and an erythrocyte sedimentation rate of 100 mm/h. Which of the following is the most likely diagnosis?
Q99
A 32-year-old woman comes to the physician because she has been unable to conceive for 2 years. The patient also reports monthly episodes of pelvic and back pain accompanied by painful diarrhea for 6 years. She takes naproxen for the pain, which has provided some relief. Menses have occurred at regular 28-day intervals since menarche at the age of 11 years and last for 7 days. She is sexually active with her husband and does not use contraception. Pelvic and rectal examination shows no abnormalities. A hysterosalpingogram is unremarkable. Which of the following is the most likely underlying cause of this patient's symptoms?
Q100
A 22-year-old woman is brought to the emergency department because of a 1-day history of double vision and rapidly worsening pain and swelling of her right eye. She had an upper respiratory tract infection a week ago after which she has had nasal congestion, recurrent headaches, and a purulent nasal discharge. She took antibiotics for her respiratory tract infection but did not complete the course. She has asthma treated with theophylline and inhaled β-adrenergic agonists and corticosteroids. She appears to be in severe distress. Her temperature is 38.5°C (101.3°F), pulse is 100/min, and blood pressure is 130/80 mm Hg. Ophthalmic examination of the right eye shows proptosis and diffuse edema, erythema, and tenderness of the eyelids. Right eye movements are restricted and painful in all directions. The pupils are equal and reactive to light. There is tenderness to palpation over the right cheek and purulent nasal discharge in the right nasal cavity. The left eye shows no abnormalities. Laboratory studies show a leukocyte count of 12,000/mm3. Which of the following provides the strongest indication for administering intravenous antibiotics to this patient?
Labor Complications US Medical PG Practice Questions and MCQs
Question 91: A 23-year-old woman comes to the emergency department because of increasing abdominal pain with associated nausea and vomiting. The symptoms began suddenly after having intercourse with her partner six hours ago. There is no associated fever, diarrhea, vaginal bleeding, or discharge. Menarche was at the age of 13 years and her last menstrual period was 4 weeks ago. She uses combination contraceptive pills. She had an appendectomy at the age of 12. Her temperature is 37.5°C (99.5°F), pulse is 100/min, respirations are 22/min, and blood pressure is 110/70 mm Hg. Abdominal examination shows severe right lower quadrant tenderness with associated rebound and guarding. Pelvic examination shows scant, clear vaginal discharge and right adnexal tenderness. There is no cervical wall motion tenderness. Her hemoglobin concentration is 10.5 g/dL, leukocyte count is 9,000/mm3, and platelet count is 250,000/mm3. A urine pregnancy test is negative. Which of the following imaging findings is most likely?
A. Increased ovarian blood flow on doppler
B. Decreased ovarian blood flow on doppler (Correct Answer)
C. Complex, echogenic intrauterine mass
D. Distended fallopian tube with incomplete septations
E. Echogenic tubal ring
Explanation: ***Decreased ovarian blood flow on doppler***
- This clinical presentation, particularly the sudden onset of **unilateral abdominal pain** after intercourse, associated nausea/vomiting, and severe right lower quadrant tenderness with rebound/guarding, is highly suggestive of **ovarian torsion**.
- **Ovarian torsion** *is a medical emergency in which the ovary twists on its pedicle, obstructing its blood supply. This causes rapid onset of symptoms and can lead to necrosis of the ovary if not promptly treated.* **Doppler ultrasound** *will show decreased or absent blood flow to the affected ovary, which is key to its diagnosis*.
*Increased ovarian blood flow on doppler*
- **Increased ovarian blood flow** would suggest an inflammatory process or a highly vascularized mass, which is less consistent with the acute, severe ischemic pain described.
- *While some inflammatory conditions or ruptured cysts might present with similar pain, the sudden, severe nature following intercourse points towards a mechanical event like torsion rather than increased flow.*
*Complex, echogenic intrauterine mass*
- A **complex, echogenic intrauterine mass** is indicative of conditions like fibroids, polyps, or retained products of conception, typically presenting with abnormal uterine bleeding or chronic pelvic pain, not acute unilateral abdominal pain after intercourse.
- *The absence of vaginal bleeding and a negative pregnancy test further rule out most intrauterine pregnancy-related issues.*
*Distended fallopian tube with incomplete septations*
- A **distended fallopian tube with incomplete septations** is a hallmark of **hydrosalpinx** or **pyosalpinx**, often associated with pelvic inflammatory disease (PID).
- *While PID can cause adnexal tenderness, the acute onset after intercourse with guarding and rebound in the absence of fever, vaginal discharge (except scant clear), or cervical motion tenderness makes PID less likely.*
*Echogenic tubal ring*
- An **echogenic tubal ring** is a classic sign of an **ectopic pregnancy** within the fallopian tube.
- *The patient's negative urine pregnancy test makes ectopic pregnancy extremely unlikely, despite the adnexal pain.*
Question 92: A 66-year-old G3P3 presents with an 8-year-history of back pain, perineal discomfort, difficulty urinating, recurrent malaise, and low-grade fevers. These symptoms have recurred regularly for the past 5–6 years. She also says that there are times when she experiences a feeling of having a foreign body in her vagina. With the onset of symptoms, she was evaluated by a physician who prescribed her medications after a thorough examination and recommended a vaginal pessary, but she was non-compliant. She had 3 vaginal deliveries She has been menopausal since 51 years of age. She does not have a history of malignancies or cardiovascular disease. She has type 2 diabetes mellitus that is controlled with diet and metformin. Her vital signs include: blood pressure 110/60 mm Hg, heart rate 91/min, respiratory rate 13/min, and temperature 37.4℃ (99.3℉). On physical examination, there is bilateral costovertebral angle tenderness. The urinary bladder is non-palpable. The gynecologic examination reveals descent of the cervix to the level of the introitus. A Valsalva maneuver elicits uterine procidentia. Which pathology is most likely to be revealed by imaging in this patient?
A. Renal cyst
B. Urinary bladder polyp
C. Renal tumor
D. Hydronephrosis (Correct Answer)
E. Renal calculi
Explanation: ***Hydronephrosis***
- The patient's **uterine procidentia** (third-degree uterine prolapse) can lead to **ureteral kinking** or compression, causing obstruction of urine flow.
- This obstruction, combined with recurrent back pain, malaise, low-grade fevers, and CVA tenderness, strongly suggests **hydronephrosis** due to urinary stasis and potential recurrent UTIs.
*Renal cyst*
- While common, renal cysts are typically **asymptomatic** and do not explain the recurrent fevers, malaise, and CVA tenderness.
- They are generally **not associated with urinary obstruction** leading to such systemic symptoms.
*Urinary bladder polyp*
- Bladder polyps can cause hematuria or urinary frequency but are **unlikely to cause bilateral CVA tenderness**, back pain, or systemic symptoms like fever and malaise.
- They do not typically lead to **ureteral obstruction** or hydronephrosis.
*Renal tumor*
- A renal tumor could explain systemic symptoms like malaise and low-grade fevers, but the recurrent nature over 5-6 years and the strong association with **uterine prolapse-induced obstruction** make it less likely.
- While it can cause back pain, **bilateral CVA tenderness** and difficulty urinating are not classic presenting features.
*Renal calculi*
- Renal calculi cause **severe, colicky flank pain** that radiates, and while they can cause urinary obstruction and recurrent UTIs, the patient's long-standing, constant back pain and the context of significant **uterine prolapse** make hydronephrosis a more direct consequence.
- The symptoms described are more indicative of **chronic obstruction** rather than acute stone passage.
Question 93: A previously healthy 28-year-old woman comes to the physician because of lower abdominal pain and purulent vaginal discharge for the past 5 days. Menses occur at irregular 20 to 40-day intervals and last 4 to 8 days. She is sexually active with a new partner that she met 2 months ago and they use condoms inconsistently. She had a normal pap smear 5 months ago. She drinks 2 beers every other day. Her temperature is 39°C (102.2°F), pulse is 85/min, and blood pressure is 108/75 mm Hg. Examination shows lower abdominal tenderness and bilateral inguinal lymphadenopathy. Pelvic examination is notable for uterine and adnexal tenderness as well as small amounts of bloody cervical discharge. A spot urine pregnancy test is negative. Laboratory studies show a leukocyte count of 14,500/mm3 and an erythrocyte sedimentation rate of 90 mm/h. Nucleic acid amplification confirms the suspected diagnosis. The patient is started on ceftriaxone and doxycycline. Which of the following is the most appropriate next step in management?
A. Partner notification and treatment
B. CT scan of the abdomen
C. Colposcopy
D. Pap smear
E. HIV test (Correct Answer)
Explanation: ***HIV test***
- This patient is diagnosed with **pelvic inflammatory disease (PID)** caused by an **STI**, and individuals with one STI are at **increased risk for other STIs**, including HIV.
- Given her **inconsistent condom use** and new sexual partner, an **HIV test** is crucial for comprehensive sexual health screening.
*Partner notification and treatment*
- While **partner notification and treatment** are essential for preventing further transmission of STIs, it is not the *most immediate* next step regarding the patient's own health screening.
- This step should be initiated after counseling the patient and ensuring her own test results for other STIs are complete.
*CT scan of the abdomen*
- A **CT scan of the abdomen** is generally not indicated as a routine test for PID unless there is concern for complications like a **tubo-ovarian abscess** that is not responding to initial treatment.
- The current clinical picture and positive response to antibiotics do not immediately warrant advanced imaging.
*Colposcopy*
- A **colposcopy** is used to examine the cervix, vagina, and vulva for precancerous lesions, typically after an **abnormal Pap smear**.
- This patient had a **normal Pap smear 5 months ago**, and her current symptoms are indicative of an acute infection, not cervical dysplasia.
*Pap smear*
- She had a **normal Pap smear 5 months ago**, and her current symptoms are related to an acute infection, not cervical cancer screening.
- A **Pap smear** is not the appropriate next step for diagnosing or managing an active STI or PID.
Question 94: A 72-year-old multiparous woman comes to the physician for the evaluation of episodes of involuntary urine leakage for the past 6 months. She loses small amounts of urine without warning after laughing or sneezing. She also sometimes forgets the names of her grandchildren and friends. She is retired and lives at an assisted-living facility. She has insulin-dependent diabetes mellitus type 2. Her mother received a ventriculoperitoneal shunt around her age. She walks without any problems. Sensation to pinprick and light touch is normal. Which of the following is the primary underlying etiology for this patient's urinary incontinence?
A. Urethral hypermobility (Correct Answer)
B. Decreased cerebrospinal fluid absorption
C. Detrusor-sphincter dyssynergia
D. Impaired detrusor contractility
E. Loss of sphincter control
Explanation: ***Urethral hypermobility***
- This patient presents with **stress urinary incontinence**, characterized by involuntary urine leakage during activities that increase intra-abdominal pressure, such as **laughing or sneezing**.
- **Urethral hypermobility** is a common cause of stress incontinence, where the urethra and bladder neck rotate downward and backward during increased abdominal pressure, compromising sphincter function.
*Decreased cerebrospinal fluid absorption*
- This is linked to **normal pressure hydrocephalus**, presenting with a triad of **gait disturbance**, **urinary incontinence**, and **dementia**.
- While the patient has incontinence and memory issues, her normal gait and the absence of clear hydrocephalus symptoms makes this less likely to be the primary cause of her specific type of incontinence.
*Detrusor-sphincter dyssynergia*
- This condition involves uncoordinated contraction of the **detrusor muscle** and external urethral sphincter, typically seen in individuals with **neurological disorders** like spinal cord injury.
- It results in incomplete bladder emptying and usually presents with urgency, frequency, and overflow incontinence, which does not match the patient's symptoms of leakage with straining.
*Impaired detrusor contractility*
- This leads to **overflow incontinence**, where the bladder is unable to empty completely and continuously leaks urine.
- Symptoms usually include a weak stream, hesitancy, and a feeling of incomplete emptying, which are not described in this patient.
*Loss of sphincter control*
- This can cause **stress incontinence**, but the term "loss of sphincter control" is a broad description. **Urethral hypermobility** specifically describes the mechanical mechanism leading to the loss of effective sphincter closure during exertion.
- While related, urethral hypermobility is a more specific and accurate primary etiology for stress incontinence in this context.
Question 95: A 29-year-old woman, gravida 1, para 0, at 38 weeks' gestation comes to the emergency department for sudden leakage of clear fluid from her vagina. Her pregnancy has been uncomplicated. She has largely been compliant with her prenatal care but missed some appointments. She has a history of chronic hypertension. She drinks a glass of wine once per week. Current medications include labetalol, iron, and vitamin supplements. Her temperature is 37.9°C (100.2°F), pulse is 70/min, respirations are 18/min, and blood pressure is 128/82 mm Hg. Examination shows a soft and nontender abdomen on palpation. Speculum examination demonstrates clear fluid in the cervical canal. The fetal heart rate is reactive at 170/min with no decelerations. Tocometry shows no contractions. The vaginal fluid demonstrates a ferning pattern when placed onto a glass slide. Which of the following is the most likely cause of this patient's condition?
A. Cervical incompetence
B. Uterine overdistension
C. Idiopathic (unknown cause) (Correct Answer)
D. Previous history of PROM
E. Connective tissue disorders
Explanation: ***Idiopathic (unknown cause)***
- The patient presents with **spontaneous rupture of membranes (PROM)** at term, evidenced by the sudden leakage of clear fluid, a ferning pattern on microscopy, and a reactive fetal heart rate.
- While several risk factors are associated with PROM, a significant percentage of cases, especially at term, are **idiopathic**, meaning no specific underlying cause is identified despite careful evaluation.
*Cervical incompetence*
- This condition typically leads to **premature cervical dilation** and can result in **preterm premature rupture of membranes (PPROM)**, usually before 34 weeks gestation.
- The patient is at 38 weeks gestation, and her presentation is not consistent with the typical clinical course of cervical incompetence leading to term PROM.
*Uterine overdistension*
- **Uterine overdistension**, as seen in cases of **polyhydramnios** or **multiple gestations**, can be a risk factor for PROM due to increased intrauterine pressure.
- However, there is no clinical evidence in the vignette to suggest polyhydramnios (e.g., fundal height larger than dates, excessive abdominal size) or multiple gestations.
*Previous history of PROM*
- A **prior history of PROM** is a significant risk factor for recurrent PROM in subsequent pregnancies.
- However, this patient is **gravida 1, para 0**, meaning this is her first pregnancy, so a previous history of PROM is not possible.
*Connective tissue disorders*
- Certain **connective tissue disorders**, such as Ehlers-Danlos syndrome, can weaken fetal membranes and increase the risk of PROM.
- There is **no information** in the patient's history or examination to suggest a connective tissue disorder.
Question 96: A 36-year-old primigravid woman at 26 weeks' gestation comes to the physician complaining of absent fetal movements for the last 2 days. Pregnancy was confirmed by ultrasonography 14 weeks earlier. She has no vaginal bleeding or discharge. She has a history of type 1 diabetes mellitus controlled with insulin. Vital signs are all within the normal limits. Pelvic examination shows a soft, 2-cm long cervix in the midline with a cervical os measuring 3 cm and a uterus consistent in size with 24 weeks' gestation. Transvaginal ultrasonography shows a fetus with no cardiac activity. Which of the following is the most appropriate next step in management?
A. Plan for oxytocin administration (Correct Answer)
B. Perform weekly pelvic ultrasound
C. Perform dilation and curettage
D. Perform cesarean delivery
E. Administer magnesium sulfate
Explanation: ***Plan for oxytocin administration***
- The patient is at 26 weeks' gestation with confirmed fetal demise and an effaced, dilated cervix (2 cm long, 3 cm dilated). This indicates the cervix is already preparing for delivery.
- **Oxytocin** is the most appropriate next step to induce labor and facilitate vaginal delivery in cases of **intrauterine fetal demise** (IUFD) after the first trimester, especially when cervical changes have begun.
*Perform weekly pelvic ultrasound*
- The ultrasound has already confirmed **absent fetal cardiac activity**, making repeated ultrasounds unnecessary as the diagnosis of IUFD is already established.
- This option would delay necessary management and exposure to the deceased fetus in utero could increase risks such as **coagulopathy** if prolonged.
*Perform dilation and curettage*
- **Dilation and curettage (D&C)** is generally reserved for termination of pregnancy or management of miscarriage up to **16-18 weeks' gestation**.
- At **26 weeks' gestation**, the size of the fetus and uterus makes D&C a less safe and less effective procedure compared to labor induction.
*Perform cesarean delivery*
- **Cesarean delivery** for IUFD is typically reserved for cases with maternal indications (e.g., prior classical C-section scar, placenta previa obstructing the birth canal) or when labor induction fails.
- There are no maternal or fetal contraindications to vaginal delivery in this scenario, and a C-section would primarily increase maternal morbidity without fetal benefit.
*Administer magnesium sulfate*
- **Magnesium sulfate** is used for **neuroprotection** in preterm deliveries (usually before 32 weeks) and seizure prophylaxis in **preeclampsia/eclampsia**.
- As the fetus is deceased, neuroprotection is not applicable, and there are no signs of preeclampsia, making this intervention inappropriate.
Question 97: A 35-year-old G1 is brought to the emergency department because of sharp pains in her abdomen. She is at 30 weeks gestation based on ultrasound. She complains of feeling a little uneasy during the last 3 weeks of her pregnancy. She mentions that her abdomen has not been enlarging as expected and her baby is not moving as much as during the earlier part of the pregnancy. If anything, she noticed her abdomen has decreased in size. While she is giving her history, the emergency medicine physician notices that she is restless and is sweating profusely. An ultrasound is performed and her blood is sent for type and match. The blood pressure is 90/60 mm Hg, the pulse is 120/min, and the respiratory rate is 18/min. The fetal ultrasound is significant for no fetal heart motion or fetal movement. Her blood work shows the following: hemoglobin, 10.3 g/dL; platelet count, 1.1*10(5)/ml; bleeding time, 10 minutes; PT, 25 seconds; and PTT, 45 seconds. Which of the following would be the best immediate course of management for this patient?
A. Low-molecular-weight heparin
B. Fresh frozen plasma
C. Initiation of labor
D. D-dimer assay
E. IV fluids (Correct Answer)
Explanation: ***IV fluids***
- The patient presents with **hypotension** (90/60 mmHg) and **tachycardia** (120/min), indicating **hypovolemic shock**, likely due to concealed hemorrhage from abruptio placentae.
- **IV fluids** are the immediate priority to restore circulating blood volume and stabilize the patient's hemodynamic status.
*Low-molecular-weight heparin*
- This patient is experiencing signs of **disseminated intravascular coagulation (DIC)**, including thrombocytopenia, prolonged PT/PTT, and increased bleeding time, which makes anticoagulation contraindicated.
- Administering heparin would **exacerbate bleeding** and worsen her condition.
*Fresh frozen plasma*
- While **fresh frozen plasma (FFP)** can replace clotting factors and is indicated for DIC, stabilization of the patient's circulating volume with **IV fluids** is the most immediate life-saving measure in active shock.
- FFP should be given after initial fluid resuscitation and once the decision to deliver is made, to correct coagulopathy.
*Initiation of labor*
- Although the immediate delivery of the fetus is necessary to resolve ongoing placental abruption and DIC, the patient's **hemodynamic instability** must be addressed first.
- Stabilizing her with **IV fluids** is crucial before proceeding with labor induction or C-section.
*D-dimer assay*
- A **D-dimer assay** is a diagnostic test that would likely be elevated in this patient due to DIC, but it does not provide immediate therapeutic benefit.
- The patient's clinical presentation and other lab values (prolonged PT/PTT, thrombocytopenia) already strongly suggest DIC, and immediate intervention is required, not further diagnostic testing.
Question 98: A 17-year-old girl comes to the emergency department with a 5-day history of severe abdominal pain, cramping, nausea, and vomiting. She also has pain with urination. She is sexually active with one male partner, and they use condoms inconsistently. She experienced a burning pain when she last had sexual intercourse 3 days ago. Menses occur at regular 28-day intervals and last 5 days. Her last menstrual period was 3 weeks ago. Her temperature is 38.5°C (101.3°F), pulse is 83/min, and blood pressure is 110/70 mm Hg. Physical examination shows abdominal tenderness in the lower quadrants. Pelvic examination shows cervical motion tenderness and purulent cervical discharge. Laboratory studies show a leukocyte count of 15,000/mm3 and an erythrocyte sedimentation rate of 100 mm/h. Which of the following is the most likely diagnosis?
A. Ectopic pregnancy
B. Ovarian cyst rupture
C. Pyelonephritis
D. Appendicitis
E. Pelvic inflammatory disease (Correct Answer)
Explanation: ***Pelvic inflammatory disease***
- The constellation of **lower abdominal pain, fever, cervical motion tenderness, purulent cervical discharge, leukocytosis, and elevated ESR** in a sexually active young woman strongly indicates PID.
- The history of **pain during intercourse and inconsistent condom use** increases the risk for sexually transmitted infections, which are common causes of PID.
*Ectopic pregnancy*
- While it can cause unilateral abdominal pain and tenderness, it's typically associated with **amenorrhea** and **vaginal spotting**, neither of which is present, and would not cause purulent discharge or fever this high.
- A **positive pregnancy test** would be expected, but none is mentioned, and her last menstrual period was 3 weeks ago, making pregnancy less likely as a cause of such severe symptoms.
*Ovarian cyst rupture*
- Characterized by **sudden-onset, sharp, unilateral abdominal pain** which may be accompanied by nausea and vomiting, but generally **lacks fever, purulent cervical discharge, cervical motion tenderness, or leukocytosis** as prominent features.
- The symptoms in the case, particularly the signs of infection, are inconsistent with a simple cyst rupture.
*Pyelonephritis*
- Typically presents with **flank pain, fever, dysuria, and CVA tenderness**, often with urinary symptoms like frequency or urgency.
- While dysuria is present, the **prominent cervical motion tenderness and purulent cervical discharge** make pyelonephritis less likely as the primary diagnosis, although a co-infection is possible.
*Appendicitis*
- Causes periumbilical pain that migrates to the **right lower quadrant**, often with anorexia, nausea, fever, and leukocytosis, but **lacks the genitourinary symptoms** such as dysuria, cervical motion tenderness, and purulent cervical discharge.
- The patient's pain is described as lower quadrant, which can be diffuse with PID.
Question 99: A 32-year-old woman comes to the physician because she has been unable to conceive for 2 years. The patient also reports monthly episodes of pelvic and back pain accompanied by painful diarrhea for 6 years. She takes naproxen for the pain, which has provided some relief. Menses have occurred at regular 28-day intervals since menarche at the age of 11 years and last for 7 days. She is sexually active with her husband and does not use contraception. Pelvic and rectal examination shows no abnormalities. A hysterosalpingogram is unremarkable. Which of the following is the most likely underlying cause of this patient's symptoms?
A. Smooth muscle tumor arising from the myometrium
B. Increased secretion of androgens and luteinizing hormone
C. Scarring of the fallopian tubes
D. Endometrial tissue outside the uterine cavity (Correct Answer)
E. Primary failure of the ovaries
Explanation: ***Endometrial tissue outside the uterine cavity***
- The patient's symptoms of **infertility**, chronic **pelvic and back pain**, and **painful diarrhea** that partially respond to NSAIDs are classic for **endometriosis**.
- **Endometriosis** involves the presence of endometrial glands and stroma outside the uterus, leading to inflammation, pain, and scarring, which can impair fertility and cause bowel symptoms.
*Smooth muscle tumor arising from the myometrium*
- A **leiomyoma (fibroid)** can cause pelvic pain, heavy menstrual bleeding, and infertility, but it typically does not present with cyclical painful diarrhea.
- While leiomyomas can be a cause of infertility, the constellation of symptoms, particularly the **cyclical gastrointestinal symptoms**, points away from this diagnosis.
*Increased secretion of androgens and luteinizing hormone*
- This describes **Polycystic Ovary Syndrome (PCOS)**, which typically presents with irregular menses, hirsutism, and infertility.
- The patient has regular menses and no mention of androgen excess, making PCOS less likely, and PCOS does not typically cause cyclical back pain or painful diarrhea.
*Scarring of the fallopian tubes*
- While **fallopian tube scarring** can cause infertility, it is usually a consequence of infections (e.g., pelvic inflammatory disease) or endometriosis itself, rather than an isolated primary cause for this symptom complex.
- **Fallopian tube scarring** alone would not explain the cyclical pelvic pain, back pain, and painful diarrhea.
*Primary failure of the ovaries*
- **Primary ovarian insufficiency** would lead to amenorrhea or irregular cycles and menopausal symptoms due to low estrogen, which is inconsistent with this patient's regular 28-day cycles.
- It would also not explain the cyclical nature of the pelvic pain, back pain, or painful diarrhea.
Question 100: A 22-year-old woman is brought to the emergency department because of a 1-day history of double vision and rapidly worsening pain and swelling of her right eye. She had an upper respiratory tract infection a week ago after which she has had nasal congestion, recurrent headaches, and a purulent nasal discharge. She took antibiotics for her respiratory tract infection but did not complete the course. She has asthma treated with theophylline and inhaled β-adrenergic agonists and corticosteroids. She appears to be in severe distress. Her temperature is 38.5°C (101.3°F), pulse is 100/min, and blood pressure is 130/80 mm Hg. Ophthalmic examination of the right eye shows proptosis and diffuse edema, erythema, and tenderness of the eyelids. Right eye movements are restricted and painful in all directions. The pupils are equal and reactive to light. There is tenderness to palpation over the right cheek and purulent nasal discharge in the right nasal cavity. The left eye shows no abnormalities. Laboratory studies show a leukocyte count of 12,000/mm3. Which of the following provides the strongest indication for administering intravenous antibiotics to this patient?
A. Fever
B. Leukocytosis
C. Pain with eye movements (Correct Answer)
D. Worsening of ocular pain
E. Purulent nasal discharge and right cheek tenderness
Explanation: ***Pain with eye movements***
- **Pain with eye movements** accompanied by proptosis, ophthalmoplegia, and fever in the context of sinusitis strongly indicates **orbital cellulitis**.
- **Orbital cellulitis** is a serious infection posterior to the orbital septum that can rapidly lead to vision loss or intracranial spread, necessitating urgent intravenous antibiotics.
*Fever*
- While **fever** (38.5°C) suggests an infection, it is a general sign and does not specifically point to the severity or location of the infection within the orbit.
- Fever can be present in less severe conditions like **preseptal cellulitis** or uncomplicated sinusitis, which might not require immediate IV antibiotics.
*Leukocytosis*
- **Leukocytosis** (12,000/mm3) confirms an ongoing inflammatory or infectious process but, like fever, is a non-specific indicator.
- It does not differentiate between a localized infection (e.g., preseptal cellulitis) and a more critical, deep-seated infection like **orbital cellulitis**.
*Worsening of ocular pain*
- **Worsening ocular pain** contributes to the overall clinical picture of inflammation or infection in the eye region.
- However, it is less specific than **pain on eye movement** for indicating deeper orbital involvement.
*Purulent nasal discharge and right cheek tenderness*
- **Purulent nasal discharge** and **right cheek tenderness** are classic signs of **acute sinusitis**.
- While sinusitis is the likely source of infection, these symptoms alone do not confirm orbital extension and involvement requiring immediate IV antibiotics.