Insulin and oral antidiabetic agents — MCQs

A 55-year-old male is hospitalized for acute heart failure. The patient has a 20-year history of alcoholism and was diagnosed with diabetes mellitus type 2 (DM2) 5 years ago. Physical examination reveals ascites and engorged paraumbilical veins as well as 3+ pitting edema around both ankles. Liver function tests show elevations in gamma glutamyl transferase and aspartate transaminase (AST). Of the following medication, which most likely contributed to this patient's presentation?

An endocrinologist is working with a pharmaceutical research company on a new drug for diabetes mellitus type 2 (DM2). In their experimental studies, they isolated a component from Gila monster saliva, which was found to have > 50% homology with glucagon-like peptide-1 (GLP1). During the animal studies, the experimental drug was found to have no GLP1 agonist effect. Instead, it irreversibly binds DPP-IV with a higher affinity than GLP1. Which of the following drugs has a similar mechanism of action to this new experimental drug?

A 52-year-old man is seen by his endocrinologist for routine followup of his type 2 diabetes. Although he has previously been on a number of medication regimens, his A1C has remained significantly elevated. In order to try to better control his glucose level, the endocrinologist prescribes a new medication. He explains that this new medication works by blocking the ability of his kidneys to reabsorb glucose and therefore causes glucose wasting in the urine. Which of the following medications has this mechanism of action?

A 56-year-old man presents for a follow-up regarding his management for type 2 diabetes mellitus (DM). He was diagnosed with type 2 DM about 7 years ago and was recently started on insulin therapy because oral agents were insufficient to control his glucose levels. He is currently following a regimen combining insulin lispro and neutral protamine Hagedorn (NPH) insulin. He is taking insulin lispro 3 times a day before meals and NPH insulin once in the morning. He has been on this regimen for about 2 months. He says that his glucose reading at night averages around 200 mg/dL and remains close to 180 mg/dL before his shot of NPH in the morning. The readings during the rest of the day range between 100–120 mg/dL. The patient denies any changes in vision or tingling or numbness in his hands or feet. His latest HbA1C level was 6.2%. Which of the following adjustments to his insulin regimen would be most effective in helping this patient achieve better glycemic control?

A 56-year-old man with type 2 diabetes mellitus comes to the physician for a follow-up examination. He reports that he has been compliant with his current antidiabetic medication regimen. His hemoglobin A1c concentration is 8.5%. The physician prescribes a drug that reversibly inhibits a membrane-bound enzyme that hydrolyzes carbohydrate bonds. Which of the following drugs was most likely added to this patient's medication regimen?

A 58-year-old male presents to the clinic for a follow-up visit. He takes metformin every day and says that he is compliant with his medication but can not control his diet. Three months prior, his HbA1c was 8.2% when he was started on metformin. He does not have any complaints on this visit. His temperature is 37°C (98.6°F), respirations are 15/min, pulse is 67/min and blood pressure is 122/88 mm Hg. His BMI is 33. Physical examination is within normal limits. Blood is drawn for laboratory tests and the results are given below: Fasting blood glucose 150 mg/dL Glycated hemoglobin (HbA1c) 7.2 % Serum Creatinine 1.1 mg/dL BUN 12 mg/dL The physician wants to initiate another medication for his blood glucose control, specifically one that does not carry a risk of weight gain. Addition of which of the following drugs would be most suitable for this patient?

A 14-year-old boy is rushed to the emergency room after he became disoriented at home. His parents say that the boy was doing well until 2 days ago when he got sick and vomited several times. They thought he was recovering but today he appeared to be disoriented since the morning. His vitals are normal except shallow rapid breathing at a rate of 33/min. His blood sugar level is 654 mg/dL and urine is positive for ketone bodies. He is diagnosed with diabetic ketoacidosis and is managed with fluids and insulin. He responds well to the therapy. His parents are told that their son has type 1 diabetes and insulin therapy options are being discussed. Which of the following types of insulin can be used in this patient for the rapid action required during mealtimes?

A 37-year-old woman accompanied by her husband presents to the emergency department after loss of consciousness 30 minutes ago. The husband reports that she was sitting in a chair at home and began having sustained rhythmic contractions of all 4 extremities for approximately 1 minute. During transport via ambulance she appeared confused but arousable. Her husband reports she has no medical conditions, but for the past 2 months she has occasionally complained of episodes of sweating, palpitations, and anxiety. Her brother has epilepsy and her mother has type 1 diabetes mellitus. Laboratory studies obtained in the emergency department demonstrate the following: Serum: Na+: 136 mEq/L K+: 3.8 mEq/L Cl-: 100 mEq/L HCO3-: 19 mEq/L BUN: 16 mg/dL Creatinine: 0.9 mg/dL Glucose: 54 mg/dL C-peptide: Low Which of the following is the most likely diagnosis?

A 44-year-old female is brought to the emergency room after losing consciousness at a shopping mall. Her husband states that they were shopping when the patient appeared sweaty and tremulous, became confused, then collapsed. She was unconscious for 5 minutes until a paramedic arrived. Fingerstick glucose at that time was 31 mg/dL and intramuscular glucagon was administered. The patient regained consciousness as she was being transported to the ambulance. On arrival in the emergency room, she is conscious but sleepy. She is able to report that her last meal prior to the mall was 5 hours ago. Her husband notes that over the last 3 months, she has complained of headaches and a milky discharge from both breasts, as well as nausea if she goes too long without eating. She works as an inpatient nurse and was exposed to tuberculosis 10 years ago but adequately treated. Because she was adopted as an infant, family history is unknown. Temperature is 98.4 deg F (36.9 deg C), blood pressure is 101/59 mmHg, pulse is 88/min, and respiration is 14/min. Preliminary lab values are shown below: Plasma glucose: 54 mg/dL Plasma insulin: 29 pmol/L (normal < 19 pmol/L) Plasma C-peptide: 272 pmol/L (normal < 200 pmol/L) Plasma proinsulin: 8 pmol/L (normal < 5 pmol/L) Plasma ß-hydroxybutyrate: 1.2 mmol/L (normal > 2.7 mmol/L after fasting) Which of the following is the most likely cause of this patient’s hypoglycemic episode?

A 60-year-old man comes to the emergency department because of recurrent episodes of fatigue, palpitations, nausea, and diaphoresis over the past 6 months. The episodes have become more frequent in the last 2 weeks and he has missed work several times because of them. His symptoms usually improve after he drinks some juice and rests. He has had a 2-kg (4.5-lb) weight gain in the past 6 months. He has a history of bipolar disorder, hypertension, and asthma. His sister has type 2 diabetes mellitus and his mother has a history of medullary thyroid carcinoma. His medications include lithium, hydrochlorothiazide, aspirin, and a budesonide inhaler. His temperature is 36.3°C (97.3°F), pulse is 92/min and regular, respirations are 20/min, and blood pressure is 118/65 mm Hg. Abdominal examination shows no abnormalities. Serum studies show: Na+ 145 mEq/L K+ 3.9 mEq/L Cl- 103 mEq/L Calcium 9.2 mg/dL Glucose 88 mg/dL Which of the following is the most appropriate next step in diagnosis?