Vitamin/mineral functions and deficiencies — MCQs

A 58-year-old man with a history of tuberculosis treated with isoniazid and rifampin for 6 months presents with a new-onset seizure. He also reports peripheral neuropathy developing during TB treatment that never fully resolved. Current medications include only a multivitamin. Neurological examination confirms distal sensory loss and absent ankle reflexes. EEG shows focal epileptiform activity. MRI brain is unremarkable. Laboratory studies including glucose, electrolytes, and kidney function are normal. Considering his medication history and current presentation, which biochemical mechanism best explains the relationship between his previous treatment and current neurological manifestations?