Neuroanatomy — MCQs

At what age does maximum brain growth occur?

Arrange in sequence the structures involved in the direct pathway (1=Striatum, 2=GPi, 3=Thalamus, 4=Cortex output, 5=Cortex input):-

A 12-year-old boy is brought to his primary care physician because he has been tripping and falling frequently over the past 2 months. He says that he feels like he loses his balance easily and finds it difficult to walk in tight spaces such as his school hallways. Furthermore, he says that he has been experiencing insomnia over the same time period. His past medical history is significant for some mild allergies, but otherwise he has been healthy. Physical exam reveals that his eyes are fixed downwards with nystagmus bilaterally. Which of the following structures is most likely affected by this patient's condition?

One week after being involved in a bicycling accident, a 32-year-old woman comes to the physician because of intermittent double vision. She reports worsening of symptoms when she tries to type on her computer or while buttoning her shirts. Physical examination shows a slight right-sided head tilt. Her left eye is deviated laterally and upwards, which becomes even more prominent when she attempts left eye adduction. This patient's symptoms are most likely due to impaired innervation to which of the following muscles?

A 28-year-old man presented with gradually progressive gait disturbances since 10 years of age. His gait was clumsy and slow, and it was very difficult for him to perform brisk walking and running. After a few years, he developed tremors involving both upper limbs along with progressively increasing fatigability. Over the last several months, his friends have noticed that his speech has become slow, slurred, and sometimes incomprehensible. He has also developed difficulty in swallowing recently. On physical examination, he is vitally stable with normal sensorium and normal higher mental functions. The neurological examination reveals absent deep tendon reflexes in the lower extremities and the extensor plantar response bilaterally. Muscle tone is normal in different muscle groups with significant distal muscle wasting in the extremities. There is a marked loss of vibration and position senses. His gait is ataxic and nystagmus is present. His speech is explosive and dysarthric. The neurologist suspected a specific condition and asked for genetic testing, which identified 2 GAA trinucleotide repeat expansions. Which of the following is a correct statement related to the diagnosis of this patient?

A 55-year-old construction worker falls off a 2-story scaffolding and injures his back. His coworkers bring him to the urgent care clinic within 30 minutes of the fall. He complains of left lower-limb weakness and loss of sensation in the right lower limb. He does not have any past medical history. His vital signs are stable. A neurologic examination reveals a total loss of motor function when testing left knee extension, along with the left-sided loss of light touch sensation from the mid-thigh and below. There is a right-sided loss of pin-prick sensation of the lateral leg and entire foot. At this time of acute injury, what other finding is most likely to be found in this patient?

A 58-year-old woman presents with vision loss in her right eye. She noticed the visual changes the morning of presentation and has never experienced this visual disturbance before. Her medical history is significant for hypertension, hypercholesterolemia, and type II diabetes mellitus. She is currently on lisinopril, lovastatin, and metformin. She has smoked a pack of cigarettes daily for the last 25 years and also is a social drinker. On physical exam, her lids and lashes appear normal and there is no conjunctival injection. Both pupils are equal, round, and reactive to light; however, when the penlight is swung from the left eye to the right eye, there is bilateral pupillary dilation. The nerve that is most likely defective in this patient relays information to which of the following?

An otherwise healthy 58-year-old man comes to the physician because of a 1-year history of episodic coughing whenever he cleans his left ear. There is no history of hearing loss, tinnitus, or vertigo. Stimulating his left ear canal with a cotton swab triggers a bout of coughing. The physician informs him that these symptoms are caused by hypersensitivity of a cranial nerve. A peripheral lesion of this nerve is most likely to manifest with which of the following findings on physical examination?

A 25-year-old woman presents to the physician with a complaint of several episodes of headaches in the past 4 weeks that are affecting her school performance. These episodes are getting progressively worse, and over-the-counter medications do not seem to help. She also mentions having to raise her head each time to look at the board while taking notes; she cannot simply glance up with just her eyes. She has no significant past medical or family history and was otherwise well prior to this visit. Physical examination shows an upward gaze palsy and convergence-retraction nystagmus. What structure is most likely to be affected in this patient?

A 78-year-old woman is accompanied by her family for a routine visit to her primary care provider. The family states that 5 months prior, the patient had a stroke and is currently undergoing physical therapy. Today, her temperature is 98.2°F (36.8°C), blood pressure is 112/72 mmHg, pulse is 64/min, and respirations are 12/min. On exam, she is alert and oriented with no deficits in speech. Additionally, her strength and sensation are symmetric and preserved bilaterally. However, on further neurologic testing, she appears to have some difficulty with balance and a propensity to fall to her right side. Which of the following deficits does the patient also likely have?