Epithelial/Connective tissues — MCQs

A 28-year-old man presents for a pre-placement health check-up. Auscultation reveals a mid-systolic click. An echocardiogram reveals a floppy mitral valve and a dilated aortic root. An ocular examination finds a subluxated lens superior and laterally. What is the most likely genetic defect?

A 6-year-old boy with a history of multiple fractures is brought to his pediatrician by his mother, because she is concerned her child cannot hear her. On physical exam, kyphoscoliosis, poor dentition, bowing of long bones, and conductive hearing loss is noted. On genetic analysis, the patient has a COL1A1 gene mutation. The defect found in this patient is most likely associated with impaired formation of which of the following?

A 57-year-old woman comes to the physician because of increasing wrinkles on her face and sagging skin. She says that her skin used to be smooth and firm. Examination shows diffuse xerosis and mild atrophy, laxity, and fine wrinkles on the periorbital skin. Which of the following processes is most likely involved in the development of this patient's skin findings?