What is the most common cause of large bowel obstruction in adults in the United Kingdom?
A 71-year-old man with atrial fibrillation presents with sudden onset severe periumbilical pain for 2 hours. The pain is out of proportion to examination findings. His abdomen is soft with minimal tenderness. Blood tests show: WCC 18.2 × 10⁹/L, lactate 4.8 mmol/L, pH 7.32, base excess -6. CT angiography shows superior mesenteric artery occlusion. What is the most appropriate management?
A 44-year-old woman presents with a 6-hour history of right upper quadrant pain. Examination reveals Murphy's sign is positive. Her blood pressure is 118/76 mmHg, pulse 92 bpm, temperature 37.8°C. Blood tests show: WCC 12.8 × 10⁹/L, CRP 45 mg/L, bilirubin 18 µmol/L, ALP 156 U/L, ALT 68 U/L. Ultrasound shows gallstones, gallbladder wall thickening 5mm, and pericholecystic fluid. What is the most appropriate initial management?
A 52-year-old woman presents with a 4-day history of severe colicky central abdominal pain, vomiting, and absolute constipation. She had a hysterectomy 15 years ago. Examination reveals a distended abdomen with high-pitched tinkling bowel sounds. CT shows multiple dilated small bowel loops measuring 4.2 cm with collapsed large bowel and a transition point in the pelvis with a 'whirl sign'. After initial resuscitation with IV fluids and NG decompression, what is the most appropriate definitive management?
A 58-year-old man with alcoholic cirrhosis and large volume ascites develops sudden severe abdominal pain and fever. Diagnostic paracentesis shows neutrophil count 320 cells/µL. He is started on IV cefotaxime. After 48 hours of antibiotics, he remains febrile and a repeat paracentesis shows neutrophil count 380 cells/µL. What is the most important next step?
A 29-year-old man presents with sudden onset severe generalized abdominal pain following blunt trauma to the abdomen during a football match 3 hours ago. On examination, he has generalized tenderness and guarding with absent bowel sounds. HR 118 bpm, BP 105/68 mmHg. FAST scan is negative. CT with IV contrast shows free fluid, bowel wall thickening in the jejunum, and subtle discontinuity of the bowel wall. What is the most appropriate management?
A 73-year-old man with atrial fibrillation on warfarin presents with sudden onset severe left-sided abdominal pain and rectal bleeding for 6 hours. His INR is 3.2. On examination, he has left-sided abdominal tenderness without peritonism. CT shows segmental wall thickening of the descending colon with pericolic fat stranding but no pneumatosis or portal venous gas. Lactate is 1.8 mmol/L. What is the most appropriate management?
A 41-year-old woman presents with right iliac fossa pain and fever for 48 hours. She has had similar episodes in the past. CT abdomen shows an inflamed appendix with a well-defined 4 cm pericaecal collection and surrounding fat stranding. She is haemodynamically stable with temperature 38.2°C and WCC 14.8×10⁹/L. What is the most appropriate management strategy?
A 67-year-old woman taking long-term NSAIDs for osteoarthritis presents with sudden onset severe generalized abdominal pain for 4 hours. On examination, she has a rigid, board-like abdomen with absent bowel sounds and rebound tenderness. HR 105 bpm, BP 110/70 mmHg. Erect CXR shows free air under the diaphragm. After resuscitation, what is the most appropriate definitive management?
A 34-year-old woman presents with sudden onset severe epigastric pain radiating to the back, nausea and vomiting for 8 hours. She drinks 40 units of alcohol weekly. BP 100/65 mmHg, HR 115 bpm, temperature 37.9°C. Examination reveals epigastric tenderness with guarding. Serum amylase is 1850 U/L. CT shows pancreatic oedema and peripancreatic fluid stranding. What is her modified Glasgow score?
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