Radiation-Induced DNA Damage Practice Questions

Question 1

Which of the following statements about thyroid eye disease is false?

Accepted Answer

The management corresponds to improvement in thyrotoxic state

Answer

NOSPECS score is used to classify thyroid eye disease

Answer

Can lead to visual loss

Answer

Seen in more than 10% of patients with hyperthyroidism

Question 2

Radiation mediates its effect by

Accepted Answer

Ionization of the molecules

Answer

Protein coagulation

Answer

Osmolysis of cells

Answer

Denaturation of DNA

Question 3

Cell most sensitive to radiation –

Accepted Answer

Lymphocytes

Answer

Platelets

Answer

Neutrophils

Answer

Basophils

Question 4

Which part of DNA is most susceptible to radiation?

Accepted Answer

Nucleotides

Answer

Nucleosides

Answer

Double helix

Answer

Phosphate groups

Question 5

HNPCC has defect in which

Accepted Answer

Mismatch repair gene

Answer

Base excision repair

Answer

Point mutation

Answer

Nucleotide excision repair

Question 6

A patient presents with a skin rash that is exaggerated on sun exposure. What is the repair mechanism involved in this condition?

Accepted Answer

Nucleotide excision repair

Answer

Base excision repair

Answer

Mismatch repair

Answer

Double stranded DNA break repair

Question 7

Cells are most sensitive to ionizing radiation during which phase?

Accepted Answer

G2M phase

Answer

S phase

Answer

G0 phase

Answer

G1 phase

Question 8

The component of cell most affected by radiation?

Accepted Answer

DNA

Answer

Cell wall

Answer

Cell membrane

Answer

Cytoplasm

Question 9

Radiation causes cell death by:

Accepted Answer

Ionization

Answer

Charring of nucleoproteins

Answer

Disruption of cytosol

Answer

Destroying their mitochondria

Question 10

Which of the following is not a risk factor for cholangiocarcinoma?

Accepted Answer

Aflatoxin

Answer

Thorotrast

Answer

Radon

Answer

Dioxin

Radiation-Induced DNA Damage — MCQs

Radiation-Induced DNA Damage — MCQs

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