AI Applications in Breast Imaging — MCQs
The most important prognostic factor in carcinoma of the breast is
Which of the following features on mammogram would suggest malignancy?
Which of the following is the most sensitive investigation for ductal carcinoma in situ (DCIS) of the breast?
Gold standard investigation for breast carcinoma screening in a patient with silicone breast implants
Mammography can be best used in?
All of the following are true about mammography except -
What is the next best step for a 22-year-old with a hepatic hemangioma on ultrasound?
Which is not echogenic while doing ultrasonography:
Which of the following ultrasound features of a thyroid nodule is not suggestive of malignancy?
A 45-year-old female presents with a 2 cm thyroid nodule. Which TIRADS category has >95% risk of malignancy?
AI Applications in Breast Imaging Indian Medical PG Practice Questions and MCQs
Question 1: The most important prognostic factor in carcinoma of the breast is
- A. Size of tumour
- B. Skin involvement
- C. Axillary gland involvement (Correct Answer)
- D. Involvement of muscles
Explanation: ***Axillary gland involvement*** - The presence and number of involved **axillary lymph nodes** are the single most significant factor in determining prognosis and guiding adjuvant therapy in breast cancer. - Lymphatic spread to the axillary nodes indicates a higher likelihood of distant metastasis, directly impacting survival rates. *Size of tumour* - While **tumor size** is an important prognostic factor and is part of the TNM staging system (T for tumor size), it is less significant than nodal status. - A small tumor with nodal involvement has a worse prognosis than a larger tumor without nodal involvement. *Skin involvement* - **Skin involvement** (T4b in TNM staging) indicates locally advanced disease and is a poor prognostic sign, but it is not as universally important as axillary nodal status in predicting overall survival. - It often reflects aggressive local tumor growth rather than systemic spread as directly as nodal metastasis. *Involvement of muscles* - **Muscle involvement** (specifically the pectoralis major muscle, T4a in TNM staging) signifies locally advanced disease and is associated with a poor prognosis. - Similar to skin involvement, it suggests extensive local spread but is not as strong a predictor of distant metastasis and overall survival as axillary nodal involvement.
Question 2: Which of the following features on mammogram would suggest malignancy?
- A. Smooth borders
- B. Well defined lesion
- C. A mass of decreased density
- D. Areas of spiculated microcalcifications (Correct Answer)
Explanation: ***Areas of spiculated microcalcifications*** - **Spiculated microcalcifications** are highly suspicious for malignancy due to their irregular shape, distribution, and association with rapid, uncontrolled cell growth. - These calcifications often represent **necrotic cells** within rapidly growing tumors, which can deposit calcium. *Smooth borders* - **Smooth borders** typically indicate a benign lesion, such as a cyst or fibroadenoma, as they suggest gradual, uniform growth rather than invasive spread. - Malignant lesions tend to have **irregular** or ill-defined borders due to their infiltrative nature. *Well defined lesion* - A **well-defined lesion** usually suggests a benign process, as it indicates a mass that is clearly demarcated from surrounding tissue and is likely encapsulated. - Malignancies, conversely, often exhibit **indistinct or irregular margins** as they invade adjacent structures. *A mass of decreased density* - A mass of **decreased density** is generally considered a benign finding, often representing a **cyst** or an area of normal fatty tissue. - Malignant tumors typically present as a **mass of increased density** due to their cellular proliferation and desmoplastic reaction.
Question 3: Which of the following is the most sensitive investigation for ductal carcinoma in situ (DCIS) of the breast?
- A. PET Scan
- B. Ultrasound
- C. Mammography (Correct Answer)
- D. MRI
Explanation: ***Mammography*** - **Mammography** is the **gold standard** and **primary imaging modality** for detecting **ductal carcinoma in situ (DCIS)**, primarily because it excels at visualizing **microcalcifications**, which are the hallmark of DCIS. - Approximately **80-90% of DCIS cases** present as **microcalcifications** on mammograms, making it the most important screening and diagnostic tool. - Mammography has **high sensitivity (85-95%)** for detecting DCIS, especially calcified forms, and is widely available and cost-effective. *MRI* - While **MRI** has high sensitivity for invasive breast cancer and can detect non-calcified DCIS, it is **not the primary screening tool** for DCIS detection. - MRI is typically used for **staging known DCIS**, evaluating **extent of disease**, detecting **additional foci**, and screening **high-risk patients**. - However, MRI has lower specificity and higher false-positive rates compared to mammography, limiting its use as a primary diagnostic tool. *PET Scan* - **PET scans** are generally **not sensitive** for detecting **DCIS** because DCIS lesions typically have a **low metabolic rate** and do not avidly take up the **FDG tracer**. - PET scans are primarily used for detecting **invasive cancers** and assessing **metastatic disease**, not for non-invasive lesions like DCIS. *Ultrasound* - **Ultrasound** has **limited sensitivity** for detecting **DCIS** because DCIS often does not present as a palpable mass or a distinct sonographic abnormality. - While ultrasound can be useful for evaluating palpable masses or guiding biopsies, it frequently **misses microcalcifications** that are characteristic of DCIS. - Ultrasound is mainly used as a **complementary tool** to mammography, not as a primary diagnostic modality for DCIS.
Question 4: Gold standard investigation for breast carcinoma screening in a patient with silicone breast implants
- A. Mammography
- B. CT scan
- C. USG
- D. MRI (Correct Answer)
Explanation: ***MRI*** - **MRI** is considered the **gold standard** for breast cancer screening in patients with silicone breast implants due to its superior ability to visualize breast tissue through the implant and detect subtle lesions. - It offers **high sensitivity** in detecting both implant rupture and early malignancies, often providing better clarity than mammography in augmented breasts where implants can obscure tissue. *Mammography* - While a standard screening tool, **mammography** can be limited in patients with silicone implants because the implants can **obscure adjacent breast tissue**, making detection of small masses challenging. - Special views (e.g., **Eklund views**) can be used, but sensitivity is still reduced compared to MRI in augmented breasts. *CT scan* - **CT scans** are not routinely used for primary breast cancer screening due to their use of **ionizing radiation** and lower sensitivity for detecting early breast lesions compared to MRI. - CT is more commonly used for **staging** advanced cancers or evaluating complex masses detected by other modalities. *USG* - **Ultrasound (USG)** is a valuable complementary tool, especially for evaluating palpable lumps or clarifying findings from mammography, but it is **operator-dependent** and has a lower overall sensitivity for general screening compared to MRI. - It is particularly useful for differentiating between **cystic and solid masses** and detecting implant ruptures but is not the gold standard for comprehensive screening in augmented breasts.
Question 5: Mammography can be best used in?
- A. Early breast carcinoma (Correct Answer)
- B. Mastitis
- C. Fibroadenoma
- D. Phylloides tumor
Explanation: ***Early breast carcinoma*** - **Mammography** is the gold standard for **early detection of breast carcinoma**, particularly for identifying **microcalcifications** and small masses before they are palpable. - It plays a crucial role in **screening asymptomatic women** to reduce breast cancer mortality. *Mastitis* - **Mastitis** is an **inflammatory condition** of the breast, often associated with infection, which is usually diagnosed clinically. - While mammography might show diffuse **increased density**, it is not the primary diagnostic tool and often has limited value due to inflammatory changes masking pathology. *Fibroadenoma* - **Fibroadenomas** are **benign breast tumors** common in younger women, typically appearing as well-circumscribed masses on mammography. - While mammography can detect them, their characterization often requires **ultrasound** and **biopsy** for definitive diagnosis, as differentiation from malignant lesions can be challenging. *Phylloides tumor* - A **Phylloides tumor** is a rare tumor that can be benign, borderline, or malignant, and it typically presents as a rapidly growing, palpable mass. - Mammography may show a well-defined mass, but **ultrasound** and **core needle biopsy** are essential for accurate diagnosis and distinction from fibroadenomas or malignancy.
Question 6: All of the following are true about mammography except -
- A. It is basically X ray imaging of the breast
- B. It is a screening tool in breast cancer
- C. It has a significant radiation risk (Correct Answer)
- D. It can detect microcalcifications
Explanation: ***It has a significant radiation risk*** - While mammography involves **ionizing radiation**, the amount for a screening examination is very low, approximating that received from **natural background radiation** over a few weeks. - The benefits of early breast cancer detection significantly outweigh the extremely small theoretical risk of radiation-induced cancer. *It is basically X-ray imaging of the breast* - Mammography uses **low-dose X-rays** to create images of the breast tissue. - This imaging technique is specifically optimized to visualize dense and subtle changes within the breast. *It is a screening tool in breast cancer* - Mammography is a primary and highly effective **screening tool** used to detect breast cancer early, often before palpable lumps develop. - Regular screening significantly reduces breast cancer mortality by allowing for timely diagnosis and intervention. *It can detect microcalcifications* - Mammography is highly sensitive in detecting **microcalcifications**, which are tiny calcium deposits that can sometimes be an early sign of breast cancer, particularly ductal carcinoma in situ (DCIS). - The ability to visualize these small calcifications is crucial for early detection and diagnosis.
Question 7: What is the next best step for a 22-year-old with a hepatic hemangioma on ultrasound?
- A. Angiography
- B. CT
- C. Biopsy
- D. MRI (Correct Answer)
Explanation: ***MRI*** - **Magnetic Resonance Imaging (MRI)** is the most sensitive and specific imaging modality for confirming the diagnosis of a **hepatic hemangioma** due to its characteristic enhancement patterns. - An MRI with contrast (e.g., gadolinium) can definitively distinguish a hemangioma from other **benign or malignant liver lesions**, especially when the ultrasound findings are equivocal. *Angiography* - **Angiography** is an invasive procedure and is typically reserved for cases where **embolization** or surgical resection of a very large or symptomatic hemangioma is being considered. - It is not the initial diagnostic choice for confirming a suspected hemangioma identified on **ultrasound**. *CT* - A **CT scan** with contrast can also characterize a hemangioma, showing peripheral nodular enhancement followed by progressive centripetal fill-in. - However, **MRI** generally offers superior soft tissue contrast and provides more definitive diagnostic features for hemangiomas, particularly in younger patients where radiation exposure from CT is a concern. *Biopsy* - **Biopsy** of a suspected hepatic hemangioma is generally contraindicated due to the risk of **hemorrhage** and is rarely necessary for diagnosis. - Imaging characteristics (especially on MRI) are usually sufficient to confirm the diagnosis without the need for an invasive procedure.
Question 8: Which is not echogenic while doing ultrasonography:
- A. Bile (Correct Answer)
- B. Bone
- C. Gas
- D. Gall stones
Explanation: ***Bile*** - Bile is largely composed of **water**, which allows ultrasound waves to pass through it with minimal reflection, appearing **anechoic** (black) on ultrasound. - This property makes the gallbladder lumen, when filled with bile, appear anechoic, which is crucial for identifying structures like gallstones. *Bone* - **Bone** is highly dense and reflects a significant portion of ultrasound waves, making it appear very **echogenic** (bright) on ultrasonography. - Due to its high reflectivity, bone often produces a strong **acoustic shadow** behind it, obscuring deeper structures. *Gas* - **Gas** (air) is a strong reflector of ultrasound waves and appears brightly echogenic, often with a characteristic **dirty shadowing** or **reverberation artifact**. - The presence of gas can significantly hinder visualization of underlying tissues due to its strong reflection and scatter of the ultrasound beam. *Gall stones* - **Gallstones** are solid concretions that are highly reflective of ultrasound waves, appearing as bright, **echogenic foci** within the gallbladder lumen. - A classic ultrasound sign of gallstones is an echogenic structure with strong **posterior acoustic shadowing**.
Question 9: Which of the following ultrasound features of a thyroid nodule is not suggestive of malignancy?
- A. Hypoechogenicity
- B. Hyperechogenicity (Correct Answer)
- C. Microcalcification
- D. Nonhomogeneous
Explanation: ***Hyperechogenicity*** - A **hyperechoic** thyroid nodule appears brighter than the surrounding parenchyma on ultrasound, typically indicating a benign lesion, such as a **colloid nodule**. - This feature suggests a higher reflection of sound waves, characteristic of tissues rich in **fluid or colloid material**. *Hypoechogenicity* - **Hypoechoic** nodules appear darker than the surrounding thyroid tissue, which is a strong indicator of malignancy due to their often dense cellular structure. - This feature is associated with a higher risk of thyroid cancer and often prompts further investigation with **fine-needle aspiration (FNA)**. *Microcalcification* - The presence of **microcalcifications** (tiny, bright spots) within a thyroid nodule is one of the most specific ultrasound signs of **papillary thyroid carcinoma**. - These calcifications, often punctate, represent psammoma bodies, which are a histopathological hallmark of this common thyroid cancer. *Nonhomogeneous* - A **nonhomogeneous** (heterogeneous) echotexture within a thyroid nodule, characterized by irregular internal architecture, can be suggestive of malignancy. - This often indicates disorganized cellular growth, fibrosis, or cystic degeneration with solid components, which are features seen in various thyroid cancers.
Question 10: A 45-year-old female presents with a 2 cm thyroid nodule. Which TIRADS category has >95% risk of malignancy?
- A. TIRADS 4
- B. TIRADS 2
- C. TIRADS 5 (Correct Answer)
- D. TIRADS 3
Explanation: ***TIRADS 5*** - A **TIRADS 5** classification indicates a **highly suspicious** nodule with features strongly suggestive of **malignancy**. - This category corresponds to a **>95% risk of malignancy**, necessitating further investigation such as fine-needle aspiration (FNA). *TIRADS 4* - **TIRADS 4** nodules are classified as **moderately suspicious** for malignancy, with a risk ranging from **5% to 50%**. - While requiring follow-up and often FNA, the risk is significantly lower than for TIRADS 5. *TIRADS 2* - **TIRADS 2** nodules are considered **benign**, with a **0% risk of malignancy** (or extremely low). - These nodules typically have features like **spongiform appearance** or purely cystic composition. *TIRADS 3* - **TIRADS 3** nodules are classified as **mildly suspicious**, with a malignancy risk between **0% and 5%**. - They often have some indeterminate features but are predominantly considered to be low risk.
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