Post-Translational Modifications — MCQs

Techniques used for protein expression proteomics study include:

Ubiquitin is involved in what process?

During eukaryotic protein synthesis, phosphorylation of which of the following is enhanced by insulin?

What is the major site of protein glycosylation?

Recombinant human insulin is made by -

With reference to human body's requirement for proteins, they are essential because they are: 1. an important alternative source for energy during specific metabolic states. 2. the primary molecules responsible for maintenance of osmotic pressure within the extracellular compartment. 3. critical for upkeep of cell mediated immune response. 4. vital for the synthesis of certain hormones. Which of the statements given above are correct?

Thyroid hormone binds to which receptor ?

ABO antigens are not found in:

A novel drug is designed to treat a genetic disorder caused by a nonsense mutation in the dystrophin gene. The drug works by allowing the ribosome to skip over the premature stop codon and continue translation. Evaluation of this therapeutic strategy reveals partial restoration of dystrophin protein with 60% of normal length but sufficient function. What is the most critical molecular consideration in determining if this approach will be clinically beneficial?

A 45-year-old woman with breast cancer is being treated with trastuzumab (Herceptin). Laboratory analysis of her tumor cells shows 100-fold amplification of a specific gene. Analysis of the signal transduction pathway reveals constitutive activation of PI3K/AKT pathway. Which receptor is most likely overexpressed?