Question 1

Question

A patient with chronic heart failure shows elevated ADH levels despite low serum osmolality (270 mOsm/kg) and hyponatremia (125 mEq/L). Critically evaluating this paradox, which represents the most physiologically sound explanation?

Accepted Answer

Non-osmotic stimuli (baroreceptors sensing decreased effective volume) override osmotic inhibition

Answer

Osmoreceptor dysfunction causing inappropriate ADH secretion

Answer

Syndrome of inappropriate ADH secretion (SIADH) from cardiac medications

Answer

Primary polydipsia causing dilutional hyponatremia with secondary ADH elevation

Integrative Physiology — MCQs

Integrative Physiology — MCQs

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