Coagulation and Fibrinolysis Practice Questions

Question 1

Von Willebrand disease involves a deficiency of which factor?

Accepted Answer

Defect in platelet adhesion due to von Willebrand factor deficiency

Answer

Defect in fibrin formation affecting clot stabilization

Answer

Generalized defects involving small blood vessels

Answer

Defect in clotting factors affecting secondary hemostasis

Question 2

All are fibric acid derivatives except which of the following?

Accepted Answer

Lovastatin

Answer

Clofibrate

Answer

Gemfibrozil

Answer

Fenofibrate

Question 3

Which of the following statements regarding von Willebrand disease is incorrect?

Accepted Answer

Type 1 von Willebrand disease presents with severe bleeding since childhood.

Answer

Type 2 von Willebrand disease is associated with a moderate bleeding tendency.

Answer

Type 3 von Willebrand disease is associated with severe deficiency of factor VIII.

Answer

Type 2 von Willebrand disease includes subtypes with varying defects in von Willebrand factor.

Question 4

Mechanism of action of tranexamic acid is

Accepted Answer

Prevents fibrinolysis

Answer

Decrease vascular permeability

Answer

Smooth muscle contraction

Answer

Activates Plasmin formation

Question 5

Following injury to a blood vessel, immediate hemostasis is achieved by:

Accepted Answer

Vasoconstriction

Answer

Fibrin deposition

Answer

Platelet adhesion

Answer

Thrombosis

Question 6

Partial thromboplastin time (PTT) correlates with which pathway or function?

Accepted Answer

Intrinsic pathway

Answer

Extrinsic pathway

Answer

Fibrinogen function

Answer

Platelet function

Question 7

The clot formed after the coagulation cascade is not stable unless extensive cross-linking occurs. This is done by:

Accepted Answer

Factor XIII

Answer

Plasmin

Answer

Thrombin

Answer

High molecular weight kininogen

Question 8

What is needed for prothrombin to thrombin conversion?

Accepted Answer

Calcium

Answer

Magnesium

Answer

Sodium

Answer

Potassium

Question 9

Which of the following drugs is a direct inhibitor of clotting factor Xa?

Accepted Answer

Apixaban

Answer

Argatroban

Answer

Fondaparinux

Answer

Aspirin

Question 10

Cortisol increases all of the following components except:

Accepted Answer

Eosinophils

Answer

Monocytes

Answer

RBCs

Answer

Platelets

Coagulation and Fibrinolysis — MCQs

Coagulation and Fibrinolysis — MCQs

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