Pharmacogenomics of Drug Transporters Practice Questions

Question 1

Pharmacodynamics deals with:-

Accepted Answer

Mechanism of action of a drug

Answer

Latency of onset

Answer

Transport of drug across the biological membranes

Answer

Mode of excretion of a drug

Question 2

Which among the following is the false statement regarding statins?

Accepted Answer

They can be given with verapamil and other enzyme inhibitors

Answer

These drugs should not be stopped even in severe conditions like injury, surgery etc.

Answer

Although HMG-CoA reductase inhibitors substantially reduce the risk of cardiovascular events, there is mild increase in lipoprotein a (Lpa) levels.

Answer

With the long term use, there is slight increase in the incidence of type 2 diabetes mellitus.

Question 3

Which drug is metabolized by glutathionation?

Accepted Answer

Dapsone

Answer

Nicotinic acid

Answer

Fosfomycin

Answer

Benzodiazepines

Question 4

Which of the following is not considered a pharmacogenetic condition?

Accepted Answer

Adenosine deaminase deficiency

Answer

Coumarin insensitivity

Answer

G6PD deficiency

Answer

Malignant hyperthermia

Question 5

Which statin is considered most potent based on mg-to-mg LDL reduction capability?

Accepted Answer

Rosuvastatin

Answer

Simvastatin

Answer

Pravastatin

Answer

Atorvastatin

Question 6

Choose the correct options regarding the route of administration and bioavailability.
A- Intravenous =1
B- 0.75< Oral <1
C-0.75 <IM ≤ 1
D- 0.75<SC ≤ 1
IM - Intramuscular
SC- Subcutaneous

Accepted Answer

A, C, D

Answer

A and D

Answer

A and C

Answer

A, B, D

Question 7

A patient on atorvastatin presents with myalgia; which test is recommended?

Accepted Answer

Creatine kinase

Answer

Liver function test

Answer

Blood urea nitrogen

Answer

Serum potassium

Question 8

Major mechanism of transport of drugs across biological membranes is:

Accepted Answer

Passive diffusion

Answer

Facilitated diffusion

Answer

Active transport

Answer

Endocytosis

Question 9

Which of the following is the platinum-based chemotherapeutic agent used as first-line treatment for ovarian carcinoma?

Accepted Answer

Cisplatin

Answer

Cyclophosphamide

Answer

Methotrexate

Answer

Dacarbazine

Question 10

Mechanism of action of allopurinol is

Accepted Answer

Xanthine oxidase inhibition

Answer

Recombinant uricase

Answer

Decrease chemotaxis

Answer

Increase uric acid excretion

Pharmacogenomics of Drug Transporters — MCQs

Pharmacogenomics of Drug Transporters — MCQs

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