Pharmacogenomics in Cardiovascular Therapeutics Practice Questions

Question 1

Which among the following is the false statement regarding statins?

Accepted Answer

They can be given with verapamil and other enzyme inhibitors

Answer

These drugs should not be stopped even in severe conditions like injury, surgery etc.

Answer

Although HMG-CoA reductase inhibitors substantially reduce the risk of cardiovascular events, there is mild increase in lipoprotein a (Lpa) levels.

Answer

With the long term use, there is slight increase in the incidence of type 2 diabetes mellitus.

Question 2

Which of the following is a characteristic of simvastatin?

Accepted Answer

Derived from fungal metabolite

Answer

Specific CYP3A4 substrate with high interaction potential

Answer

Prodrug requiring hepatic activation

Answer

Short half-life requiring evening dosing

Question 3

Which of the following is not considered a pharmacogenetic condition?

Accepted Answer

Adenosine deaminase deficiency

Answer

Coumarin insensitivity

Answer

G6PD deficiency

Answer

Malignant hyperthermia

Question 4

Effects of beta blockers on the heart are all of the following except:

Accepted Answer

Decreases duration of systole

Answer

Decrease in heart rate

Answer

May decrease cardiac output initially.

Answer

May precipitate heart failure in acute settings.

Question 5

The anticoagulant activity of warfarin can be reduced by all of the following except.

Accepted Answer

Aspirin

Answer

Rifampin

Answer

Vitamin K

Answer

Carbamazepine

Question 6

What is the PRIMARY vascular function of PGI2 (prostacyclin)?

Accepted Answer

Inhibits platelet aggregation and causes vasodilation

Answer

Promotes platelet aggregation and causes vasoconstriction

Answer

Acts primarily as a bronchoconstrictor

Answer

Stimulates inflammatory cell chemotaxis

Question 7

A patient with history of ischemic stroke was started on clopidogrel. However, she had another attack of stroke after 6 months. Which of the following is likely to be responsible for the failure of clopidogrel in this patient?

Accepted Answer

Downregulation of CYP2C19

Answer

Upregulation of CYP1A1

Answer

Downregulation of CYP2E1

Answer

Downregulation of CYP2D6

Question 8

Which of the following is non-selective 3rd generation Beta blocker ?

Accepted Answer

Carvedilol

Answer

Betaxolol

Answer

Celiprolol

Answer

Nebivolol

Question 9

What is the mechanism of action of ticagrelor?

Accepted Answer

P2Y12 receptor antagonist

Answer

Cox inhibition

Answer

Inhibition of thromboxane synthase

Answer

GPIIb/IIIa inhibition

Question 10

Coronary steal syndrome is associated with

Accepted Answer

Isoflurane

Answer

Sevoflurane

Answer

Halothane

Answer

Desflurane

Pharmacogenomics in Cardiovascular Therapeutics — MCQs

Pharmacogenomics in Cardiovascular Therapeutics — MCQs

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