Personalized Medicine Approaches Practice Questions

Question 1

Pharmacodynamics deals with:-

Accepted Answer

Mechanism of action of a drug

Answer

Latency of onset

Answer

Transport of drug across the biological membranes

Answer

Mode of excretion of a drug

Question 2

Match the following drugs with the targets of their actions:

Drugs:
A. Trastuzumab
B. Infliximab  
C. Sirolimus
D. Imatinib

Targets:
1. BCR-ABL tyrosine kinase
2. mTOR
3. TNF alpha
4. HER2/neu

Accepted Answer

A-4, B-3, C-2, D-1

Answer

A-2, B-3, C-1, D-4

Answer

A-3, B-4, C-2, D-1

Answer

A-4, B-3, C-1, D-2

Question 3

What is the mechanism of action of Warfarin?

Accepted Answer

Inhibition of Vitamin K epoxide reductase

Answer

Inhibition of gamma glutamyl carboxylase

Answer

Activation of Vitamin K epoxide reductase

Answer

Activation of gamma glutamyl carboxylase

Question 4

Which of the following is not considered a pharmacogenetic condition?

Accepted Answer

Adenosine deaminase deficiency

Answer

Coumarin insensitivity

Answer

G6PD deficiency

Answer

Malignant hyperthermia

Question 5

What is the mechanism of metabolism for alcohol, aspirin, and phenytoin at high doses?

Accepted Answer

Zero order kinetics

Answer

First pass kinetics

Answer

First order kinetics

Answer

Second order kinetics

Question 6

Which of the following clotting factors in a patient on Warfarin therapy would show the earliest decrease in functional activity?

Accepted Answer

Factor VII

Answer

Factor IX

Answer

Factor X

Answer

Prothrombin (Factor 2)

Question 7

Match the following drugs in Column A with their contraindications in Column B.

Accepted Answer

A-4, B-1, C-3, D-2

Answer

A-1, B-3, C-2, D-4

Answer

A-3, B-2, C-4, D-1

Answer

A-2, B-4, C-1, D-3

Question 8

Which of the following combinations can result in severe toxicity due to inhibition of cytochrome P450 enzymes?

Accepted Answer

Atorvastatin + Itraconazole

Answer

Amiodarone + Atorvastatin

Answer

Carbamazepine + Atorvastatin

Answer

Phenytoin + Atorvastatin

Question 9

Treatment with Herceptin in breast cancer is indicated for

Accepted Answer

Tumours with over-expressed HER2/C-erbB-2 protein

Answer

PR receptor +ve tumours

Answer

ER receptor +ve tumours

Answer

Ki-67 stain +ve tumours

Question 10

Testing of HLA-B' 5701 is recommended prior to initiation of which antiretroviral agent?

Accepted Answer

Abacavir

Answer

Atazanavir

Answer

Nelfinavir

Answer

Raltegravir

Personalized Medicine Approaches — MCQs

Personalized Medicine Approaches — MCQs

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