Drug-Receptor Interactions and Dose-Response Practice Questions

Question 1

Which of the following is a G protein coupled receptor?

Accepted Answer

M2 muscarinic receptor

Answer

NMDA receptor

Answer

Insulin receptors

Answer

Steroid receptors

Question 2

The therapeutic index of a drug is defined as the ratio between the toxic dose and the effective dose.

Accepted Answer

Ratio of toxic dose to effective dose

Answer

Margin of safety

Answer

Efficacy of the drug

Answer

Drug potency

Question 3

Variation in sensitivity of response to different doses of a drug in different individuals is obtained from?

Accepted Answer

Dose-response relationship

Answer

Therapeutic index

Answer

Bioavailability

Answer

Phase 1 clinical trials

Question 4

Which of the following best demonstrates the variability in drug responsiveness among individuals?

Accepted Answer

Quantal Dose Response Curve

Answer

Potency

Answer

Efficacy

Answer

Graded Dose Response Curve

Question 5

With which of the following receptors does theophylline have an antagonistic interaction?

Accepted Answer

Adenosine receptors

Answer

Histamine receptors

Answer

Imidazoline receptors

Answer

Bradykinin receptors

Question 6

Find therapeutic index of drug from the information given below in the graph

Accepted Answer

16

Answer

8

Answer

1024

Answer

128

Question 7

Which one of the following is true for competitive antagonism?

Accepted Answer

Agonist and competitive antagonist bind to the same receptor

Answer

Agonist cannot displace an antagonist from the receptor

Answer

Antagonism cannot be completely reversed by an increased dose of an agonist

Answer

Maximum response (Emax) is reduced in the presence of a competitive antagonist

Question 8

Which of the following is false about drugs given in urinary incontinence

Accepted Answer

Tolterodine can be given as transdermal patch

Answer

Oxybutynin, Tolterodine, and Solifenacin are muscarinic receptor blockers used to decrease detrusor muscle contraction

Answer

Darifenacin is a selective M3 antagonist

Answer

Trospium is a quaternary amine with no CNS side effects

Question 9

When two different chemicals act on two different receptors and their responses are opposite to each other on the same cell, this phenomenon is called?

Accepted Answer

Physiological antagonism

Answer

Chemical antagonism

Answer

Reversible antagonism

Answer

Competitive antagonism

Question 10

The graph below shows dose-response curves for three drugs A, B, and C. Which of the following drugs has the highest potency?

Accepted Answer

Drug A

Answer

Drug B

Answer

Drug C

Answer

Both Drug A & B

Drug-Receptor Interactions and Dose-Response — MCQs

Drug-Receptor Interactions and Dose-Response — MCQs

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