Anticancer Drugs — MCQs

Question 611: Hand and foot syndrome can be caused by:

• A. Cisplatin
• B. Capecitabine (Correct Answer)
• C. Dactinomycin
• D. Vinblastine

Explanation: ***Capecitabine*** - **Capecitabine** is a **prodrug** of 5-fluorouracil that is well-known for causing **hand-foot syndrome (palmar-plantar erythrodysesthesia)**. - This adverse effect is characterized by **erythema**, **swelling**, **pain**, and **desquamation** of the palms and soles. *Cisplatin* - **Cisplatin** is an **alkylating agent** primarily associated with **nephrotoxicity**, **ototoxicity**, and severe **nausea and vomiting**. - It is not a common cause of **hand-foot syndrome**. *Dactinomycin* - **Dactinomycin** (actinomycin D) is an **antibiotic chemotherapy agent** primarily associated with **myelosuppression**, **mucositis**, and **extravasation leading to tissue necrosis**. - While skin reactions can occur, **hand-foot syndrome** is not a characteristic side effect. *Vinblastine* - **Vinblastine** is a **vinca alkaloid** that inhibits microtubule formation, leading to **myelosuppression**, **peripheral neuropathy**, and **constipation**. - **Hand-foot syndrome** is not a typical adverse effect of vinblastine.