Question 1

Q: Which of the following best describes the mechanism of action of colchicine in acute attack of gout?

Inhibit migration of neutrophil chemotaxis. ***Inhibit migration of neutrophil chemotaxis*** - Colchicine binds to **tubulin**, preventing its polymerization into microtubules, which disrupts the **cytoskeletal function** required for neutrophil motility and migration. - By inhibiting the **chemotaxis** and phagocytosis of neutrophils into the affected joint, it reduces the **inflammatory response** triggered by urate crystals. *Inhibition of xanthine oxidase* - This is the primary mechanism of **allopurinol** and **febuxostat**, which are used for chronic gout management to lower serum uric acid levels. - It does not provide significant anti-inflammatory relief during an **acute gouty flare**. *Inhibition of cyclooxygenase (COX)* - This describes the mechanism of **NSAIDs** (like indomethacin or naproxen), which reduce prostaglandin synthesis to provide analgesia. - While NSAIDs are used for acute gout, they act through a completely different pathway than the microtubule-inhibiting effects of colchicine. *Blockade of IL-1 receptors* - This is the mechanism of **anakinra**, a biological DMARD, which targets the interleukin-1 pathway involved in the inflammatory cascade. - While the **NLRP3 inflammasome** (which produces IL-1beta) is indirectly inhibited by the downstream effects of colchicine, it is not a direct blockade of the IL-1 receptor itself.

Question

Which of the following best describes the mechanism of action of colchicine in acute attack of gout?

Accepted Answer

Inhibit migration of neutrophil chemotaxis

Answer

Inhibition of xanthine oxidase

Answer

Inhibition of cyclooxygenase (COX)

Answer

Blockade of IL-1 receptors

Analgesics and Anti-inflammatory Drugs — MCQs

Analgesics and Anti-inflammatory Drugs — MCQs

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