Respiratory Diseases Practice Questions

Q: Which of the following is not a recommended treatment for bronchiolitis?

Macrolides. ***Macrolides*** - **Macrolide antibiotics** are *not* recommended for treatment of **bronchiolitis**, as the condition is primarily caused by **viral infections** (mainly RSV), rendering antibiotics completely ineffective. - Bronchiolitis is a **viral illness**, and use of antibiotics like macrolides provides *no benefit*, increases risk of **antibiotic resistance**, and may cause unnecessary side effects. - This is the **most clearly not recommended** option among the choices. *Humid oxygen* - While **supplemental oxygen** is indicated for infants with **hypoxemia** (oxygen saturation <90%), **routine humidification** of oxygen is *not specifically recommended* by current guidelines. - Evidence does *not support* routine use of humidified oxygen therapy in bronchiolitis. - However, supplemental oxygen itself (when needed for low oxygen levels) is appropriate supportive care. *Bronchodilator* - **Bronchodilators** (like albuterol or salbutamol) are *not routinely recommended* for bronchiolitis, as most infants do not have significant **bronchospasm** and show *no sustained benefit*. - Guidelines suggest a **trial dose** may be considered, but should be *discontinued* if there is no clear clinical improvement. - The primary pathology is **bronchiolar inflammation and mucus plugging**, not reversible bronchospasm. *All of the options* - This option is incorrect because the question asks for what is "*not* recommended." - **Macrolides** are the most definitively not recommended, as they are completely ineffective against viral infections. - While bronchodilators and routine humidification also lack strong evidence, **macrolides** represent inappropriate therapy with no mechanism of benefit.

Q: A 3-month-old infant with no chest indrawing and a respiratory rate of 52/minute. The diagnosis is:

Pneumonia. ***Pneumonia*** - A respiratory rate of 52/minute in a 3-month-old infant **meets the age-specific threshold for tachypnea** (respiratory rate ≥ 50 breaths/minute for infants 2-12 months according to IMCI guidelines). - In the **absence of chest indrawing**, the presence of fast breathing (tachypnea) alone classifies this as **pneumonia** per IMCI classification. - This requires **outpatient management with oral antibiotics** and close follow-up. *No pneumonia* - This diagnosis would apply if the respiratory rate was **< 50 breaths/minute** for this age group with no chest indrawing. - Since the respiratory rate is 52/minute (≥ 50/minute), this rules out "no pneumonia." *Severe pneumonia* - This diagnosis requires the presence of **chest indrawing** in addition to fast breathing. - The question explicitly states **"no chest indrawing,"** which excludes severe pneumonia. - Severe pneumonia would require **hospitalization and parenteral antibiotics**. *Very severe disease* - This diagnosis involves **danger signs** such as inability to drink or breastfeed, persistent vomiting, convulsions, lethargy, unconsciousness, or severe malnutrition. - None of these critical signs are mentioned in the clinical scenario. - Very severe disease requires **urgent hospitalization and injectable antibiotics**.

Q: Most important feature to diagnose severe pneumonia?

Chest indrawing. ***Chest indrawing*** - **Chest indrawing** is a critical sign of severe respiratory distress in pneumonia, indicating increased effort needed for breathing as the body attempts to draw in more air. - This symptom suggests that the affected individual's respiratory muscles are working harder than normal to overcome airway obstruction or reduced lung compliance, often leading to **hypoxia**. *Cyanosis* - While a serious sign of **hypoxemia**, **cyanosis** is often a late manifestation and not visible until oxygen saturation drops significantly. - It indicates advanced **respiratory failure** and may not be the earliest or most sensitive indicator of severe pneumonia. *Nasal flaring* - **Nasal flaring** is a sign of increased respiratory effort seen more commonly in infants and young children. - While it indicates **respiratory distress**, it is less specific for the severity of pneumonia compared to chest indrawing, which suggests more pronounced ventilatory compromise. *Fast breathing* - **Fast breathing** (tachypnea) is a common sign of pneumonia across all severities, as the body tries to compensate for reduced oxygen exchange. - However, it is not specific enough on its own to diagnose **severe pneumonia**, and other signs of increased respiratory effort like chest indrawing are needed to indicate severe disease [1].

Q: A child presents with recurrent pulmonary infections and hemoptysis due to associated bronchiectasis. Imaging shows unilateral loss of lung volume with hyperlucency on chest radiograph and reduced vascularity on CT scan of the chest. The abdominal organs are normally placed. What is the most likely cause?

Swyer-James-MacLeod syndrome. ***Swyer-James-MacLeod syndrome*** - This syndrome presents with **unilateral hyperlucent lung**, reduced vascularity, and bronchiectasis, often following a severe childhood respiratory infection, leading to air trapping and recurrent infections. - The imaging findings of **unilateral loss of lung volume**, hyperlucency, and reduced vascularity are classic for Swyer-James-MacLeod syndrome, which is also known as unilateral emphysema. *Immotile cilia syndrome* - This is a broader term that encompasses conditions like Kartagener syndrome, characterized by ciliary dysfunction leading to **recurrent sinopulmonary infections**; however, it does not typically present with unilateral hyperlucent lung or reduced vascularity. - While it causes bronchiectasis, the specific imaging findings described (unilateral hyperlucency) are not characteristic of isolated immotile cilia syndrome. *Kartagener syndrome* - This is a subgroup of primary ciliary dyskinesia that includes the classic triad of **situs inversus**, bronchiectasis, and sinusitis. The patient in the prompt has normally placed abdominal organs, ruling out situs inversus. - Although it involves recurrent pulmonary infections and bronchiectasis, the presence of **normally placed abdominal organs** and unilateral hyperlucency on imaging makes Kartagener syndrome less likely. *Mendelson syndrome* - This refers to **chemical pneumonitis** caused by the aspiration of gastric contents, typically during anesthesia or in patients with impaired consciousness. - It presents acutely with respiratory distress, hypoxemia, and diffuse infiltrates on imaging, which is inconsistent with the chronic presentation of recurrent infections and unilateral hyperlucency described.

Q: Which one of the following conditions does not typically present with inspiratory stridor in children?

Bronchiolitis. ***Bronchiolitis*** - This condition primarily affects the **small airways** (bronchioles) and is caused by inflammation and swelling, leading to **expiratory wheezing** and difficulty breathing, rather than inspiratory stridor. - While it can cause respiratory distress, the narrowing of the lower airways typically manifests as **wheezing and crackles**, not the harsh, high-pitched sound of inspiratory stridor associated with upper airway obstruction. *Laryngomalacia* - This is a common congenital condition characterized by the collapse of **supraglottic structures** during inspiration, leading to intermittent **inspiratory stridor** that is often worse when the infant is feeding, agitated, or supine. - The stridor is typically **soft and musical**, and usually improves spontaneously as the child grows. *Acute epiglottitis* - This is a severe and rapidly progressive bacterial infection of the **epiglottis**, which can cause significant **upper airway obstruction** and life-threatening inspiratory stridor. - Children with epiglottitis often present with a **sudden onset of high fever**, sore throat, **drooling**, and a **"tripod" position** (leaning forward with neck extended). *Croup* - This condition, typically caused by a viral infection, leads to **subglottic inflammation** and swelling, resulting in the characteristic **"barking" cough** and **inspiratory stridor**. - The stridor is due to the narrowing of the trachea below the vocal cords.

Q: A 10-year-old male child presenting with complaints of poor growth, poor appetite, short stature, clubbing, and recurrent chest infections, along with steatorrhea, is most likely diagnosed with what?

Cystic fibrosis. ***Cystic fibrosis*** - The constellation of **poor growth**, **short stature**, **recurrent chest infections**, **clubbing**, and **steatorrhea** is highly indicative of cystic fibrosis. - **Cystic fibrosis** is a genetic disorder affecting exocrine glands, leading to thick, sticky mucus that clogs the lungs and pancreas, causing malabsorption. *Celiac Disease* - **Celiac disease** primarily affects the small intestine, leading to malabsorption and poor growth. - While it can cause steatorrhea and poor growth, it does not typically present with recurrent chest infections or significant clubbing. *Biliary cirrhosis* - **Biliary cirrhosis** involves liver damage and can cause steatorrhea due to impaired bile flow. - However, it is not typically associated with recurrent chest infections or prominent clubbing unless advanced. *Bronchiectasis* - **Bronchiectasis** is characterized by permanent dilation of the bronchi, leading to chronic cough and recurrent respiratory infections. - While it can cause clubbing and recurrent chest infections, it does not directly cause steatorrhea or poor growth as a primary feature, although malnutrition can occur secondary to chronic illness.

Q: What is the most appropriate antibiotic choice for a 4-year-old unvaccinated child with epiglottitis?

Ceftriaxone or cefotaxime. ***Ceftriaxone or cefotaxime*** - **Third-generation cephalosporins** are the **first-line antibiotics** for epiglottitis in children - Provide excellent coverage against ***Haemophilus influenzae* type b (Hib)**, the most common causative organism in unvaccinated children - Effective against **both beta-lactamase producing and non-producing strains**, addressing the widespread ampicillin resistance (20-40%) - **Ceftriaxone** (50-100 mg/kg/day) or **cefotaxime** (150-200 mg/kg/day divided) are standard of care - Treatment duration is typically **7-10 days** *Immediate airway assessment and management* - While this is the **most critical priority** in epiglottitis management (life-threatening airway obstruction risk), the question specifically asks for **antibiotic choice** - Airway management is a procedural intervention, not antimicrobial therapy - In clinical practice, airway assessment comes first, but this doesn't answer the question asked *Administering a vaccine* - **Hib vaccine** is a **preventive measure**, not a treatment for active infection - Vaccination during acute epiglottitis has no therapeutic benefit - The vaccine prevents future disease but does not treat current infection *Doxycycline for 4 days* - **Not first-line therapy** for epiglottitis in any age group - **Contraindicated in children under 8 years** due to risk of permanent **tooth discoloration** and enamel hypoplasia - Poor coverage against *H. influenzae* type b - Tetracyclines are not recommended for typical bacterial causes of epiglottitis

Q: A child with recent onset of upper respiratory tract infection after 2 days presents with acute onset of breathlessness, cough, and fever. Which of the following treatments is contraindicated?

Morphine. ***Morphine (CONTRAINDICATED)*** - Morphine is a **potent respiratory depressant** and is **absolutely contraindicated** in a child with acute breathlessness and respiratory infection. - It suppresses the respiratory drive, worsening hypoxia and potentially leading to **respiratory failure**. - The sedative effects mask crucial clinical signs of deteriorating respiratory status, delaying life-saving interventions. - **Opioids should never be used** in acute respiratory distress in children. *Antipyretics (NOT contraindicated)* - **Paracetamol** or **ibuprofen** are safe and appropriate for fever management in children with respiratory infections. - They improve patient comfort without adversely affecting respiratory function. - Fever reduction helps decrease metabolic demand and oxygen consumption. *Antibiotics (NOT contraindicated)* - Indicated when **bacterial pneumonia** or bacterial superinfection complicates the viral URI. - Choice depends on clinical assessment, chest X-ray findings, and laboratory markers (elevated WBC, CRP). - Common organisms include *Streptococcus pneumoniae* and *Haemophilus influenzae*. *O2 inhalation (NOT contraindicated)* - **Essential treatment** for hypoxia (SpO2 <92-94%) in acute respiratory distress. - Delivered via nasal prongs, face mask, or high-flow nasal cannula depending on severity. - Oxygen therapy is a **life-saving intervention** and should never be withheld.

Q: Which of the following is not associated with primary ciliary dyskinesia?

Hypothyroidism. ***Hypothyroidism*** - **Hypothyroidism** is a condition related to the thyroid gland's function and is **not directly associated** with defects in ciliary structure or function. - While other systemic conditions can coexist, there is no known mechanistic link between primary ciliary dyskinesia and thyroid dysfunction. *Sterility in males* - **Sterility in males** is a common manifestation of primary ciliary dyskinesia, as the abnormal cilia impair **sperm motility**, preventing effective fertilization. - The **flagellum of sperm** shares structural similarities with cilia, and its dysfunction leads to **immotile spermatozoa**. *Sinusitis* - **Sinusitis** is a hallmark symptom of primary ciliary dyskinesia due to impaired ciliary clearance in the **paranasal sinuses**. - The inability to effectively clear mucus leads to chronic and recurrent **sinus infections** and inflammation. *Respiratory infection* - **Recurrent respiratory infections**, including bronchitis, pneumonia, and bronchiectasis, are characteristic features of primary ciliary dyskinesia. - Defective ciliary action in the **respiratory tract** prevents proper clearance of mucus and pathogens, leading to chronic infections.

Q: The 'steeple sign' on X-ray neck (as shown in the image) is characteristically seen in which of the following diseases?

Croup. ***Croup*** - The image suggests a **steeple sign** on the X-ray neck, which corresponds to the subglottic narrowing characteristic of croup. - Croup, primarily caused by **parainfluenza virus**, leads to inflammation and edema below the vocal cords reducing the airway. *Epiglottitis* - Epiglottitis is characterized by a **"thumb sign"** on lateral neck X-ray, indicating a swollen epiglottis. - Patients with epiglottitis typically present with rapidly progressing airway obstruction, high fever, and drooling, unlike the gradual onset and barking cough of croup. *Laryngomalacia* - Laryngomalacia involves the **collapse of supraglottic structures** during inspiration, causing inspiratory stridor. - It would not typically present with the subglottic narrowing seen in the image, but rather with dynamic airway changes visualized during endoscopy. *Bronchiolitis* - Bronchiolitis involves inflammation of the **small airways (bronchioles)** and is usually diagnosed clinically, with chest X-rays showing hyperinflation or peribronchial cuffing if at all. - It primarily affects the lower respiratory tract and would not produce findings like the steeple sign on a neck X-ray.

Question 1

Which of the following is not a recommended treatment for bronchiolitis?

Accepted Answer

Macrolides

Answer

Bronchodilator

Answer

Humid oxygen

Answer

All of the options

Question 2

A 3-month-old infant with no chest indrawing and a respiratory rate of 52/minute. The diagnosis is:

Accepted Answer

Pneumonia

Answer

Severe pneumonia

Answer

No pneumonia

Answer

Very severe disease

Question 3

Most important feature to diagnose severe pneumonia?

Accepted Answer

Chest indrawing

Answer

Nasal flaring

Answer

Fast breathing

Answer

Cyanosis

Question 4

A child presents with recurrent pulmonary infections and hemoptysis due to associated bronchiectasis. Imaging shows unilateral loss of lung volume with hyperlucency on chest radiograph and reduced vascularity on CT scan of the chest. The abdominal organs are normally placed. What is the most likely cause?

Accepted Answer

Swyer-James-MacLeod syndrome

Answer

Immotile cilia syndrome

Answer

Kartagener syndrome

Answer

Mendelson syndrome

Question 5

Which one of the following conditions does not typically present with inspiratory stridor in children?

Accepted Answer

Bronchiolitis

Answer

Laryngomalacia

Answer

Acute epiglottitis

Answer

Croup

Question 6

A 10-year-old male child presenting with complaints of poor growth, poor appetite, short stature, clubbing, and recurrent chest infections, along with steatorrhea, is most likely diagnosed with what?

Accepted Answer

Cystic fibrosis

Answer

Celiac Disease

Answer

Biliary cirrhosis

Answer

Bronchiectasis

Question 7

What is the most appropriate antibiotic choice for a 4-year-old unvaccinated child with epiglottitis?

Accepted Answer

Ceftriaxone or cefotaxime

Answer

Administering a vaccine

Answer

Doxycycline for 4 days

Answer

Immediate airway assessment and management

Question 8

A child with recent onset of upper respiratory tract infection after 2 days presents with acute onset of breathlessness, cough, and fever. Which of the following treatments is contraindicated?

Accepted Answer

Morphine

Answer

Antipyretics

Answer

Antibiotics

Answer

O2 inhalation

Question 9

Which of the following is not associated with primary ciliary dyskinesia?

Accepted Answer

Hypothyroidism

Answer

Sinusitis

Answer

Respiratory infection

Answer

Sterility in males

Question 10

The 'steeple sign' on X-ray neck (as shown in the image) is characteristically seen in which of the following diseases?

Accepted Answer

Croup

Answer

Epiglottitis

Answer

Laryngomalacia

Answer

Bronchiolitis

Respiratory Diseases — MCQs

Respiratory Diseases — MCQs

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