Vascular Pathology Practice Questions

Q: Strawberry gingivitis is a characteristic finding in which condition?

Wegener's Granulomatosis. **Strawberry Gingivitis** is a pathognomonic clinical sign of **Wegener’s Granulomatosis** (now known as Granulomatosis with Polyangiitis or GPA). It is characterized by reddish-purple, granular, and friable swelling of the gingiva with petechial hemorrhages, resembling the surface of a strawberry. This occurs due to necrotizing granulomatous inflammation and underlying small-vessel vasculitis. [1] **Why the other options are incorrect:** * **Scorbutic Gingivitis (Vitamin C deficiency):** Presents with swollen, spongy, and bleeding gums, but lacks the specific granular "strawberry" appearance. It is associated with defective collagen synthesis. * **Plasma Cell Gingivitis:** An allergic/hypersensitivity reaction (often to toothpaste or chewing gum) showing diffuse, bright red involvement of the free and attached gingiva, characterized histologically by dense plasma cell infiltration. * **Leukemic Gingivitis:** Common in Acute Myeloid Leukemia (especially AML-M4 and M5). It presents as diffuse gingival enlargement due to direct infiltration by leukemic cells, rather than the specific granular vasculitic pattern of GPA. **NEET-PG High-Yield Pearls for GPA:** * **Triad:** Necrotizing granulomas of the respiratory tract (upper and lower), necrotizing vasculitis of small-to-medium vessels, and renal disease (crescentic glomerulonephritis). [1] * **Serology:** Highly associated with **c-ANCA** (anti-PR3 antibodies). [1] * **Classic Presentation:** Saddle-nose deformity, chronic sinusitis, hemoptysis (lung nodules/cavities), and hematuria. * **Treatment:** Cyclophosphamide and Corticosteroids. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of Infancy and Childhood, pp. 518-520.

Question 1

Thrombosis is initiated by?

Accepted Answer

endothelial damage

Answer

platelet activation

Answer

coagulation cascade

Answer

vasoconstriction of vessels

Question 2

Which is the most common cause for dissecting aneurysm of the thoracic aorta?

Accepted Answer

Medial degeneration

Answer

Atherosclerosis

Answer

Syphilis

Answer

Trauma

Question 3

All of the following cause necrotizing inflammation in vasculitis EXCEPT?

Accepted Answer

Kawasaki disease

Answer

Polyarteritis nodosa

Answer

Wegener's granulomatosis

Answer

Microscopic polyangiitis

Question 4

Which of the following is NOT a characteristic of atheroma resulting in angina?

Accepted Answer

Absence of macrophages

Answer

Thin fibrous cap

Answer

Thick fibrous cap

Answer

Absence of smooth muscle cells

Question 5

Which of the following is NOT a granulomatous vasculitis?

Accepted Answer

Buerger's disease

Answer

Churg-Strauss disease

Answer

Takayasu arteritis

Answer

Wegener's granulomatosis

Question 6

A patient with cystic medial necrosis and necrotizing arteritis is suffering from which condition?

Accepted Answer

Aortitis

Answer

Kawasaki disease

Answer

Temporal arteritis

Answer

Malignant hypertension

Question 7

Strawberry gingivitis is a characteristic finding in which condition?

Accepted Answer

Wegener's Granulomatosis

Answer

Scorbutic Gingivitis

Answer

Plasma Cell Gingivitis

Answer

Leukemic Gingivitis

Question 8

All endothelial cells are involved in the production of thrombomodulin EXCEPT those found in:

Accepted Answer

Cerebral microcirculation

Answer

Hepatic circulation

Answer

Cutaneous circulation

Answer

Renal circulation

Question 9

Which of the following is NOT a hypercoagulable state?

Accepted Answer

None of the above

Answer

Protein C resistance

Answer

Protein S deficiency

Answer

Antiphospholipid antibody

Question 10

What is the characteristic pathological feature of pyogenic granuloma?

Accepted Answer

Granulation tissue

Answer

Epithelioid cells

Answer

Cavernous hemangioma

Answer

Giant cells

Vascular Pathology — MCQs

Vascular Pathology — MCQs

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