Reproductive Pathology Practice Questions

Q: Which of the following are seen in endodermal sinus tumor?

Schiller-Duval bodies. **Explanation:** **Endodermal Sinus Tumor (Yolk Sac Tumor)** is the most common germ cell tumor in children and young infants [1]. The hallmark histological feature is the **Schiller-Duval body**. 1. **Why Option A is Correct:** Schiller-Duval bodies are pathognomonic structures consisting of a central capillary surrounded by a layer of neoplastic epithelial cells, situated within a space lined by similar cells. This configuration mimics a primitive glomerulus (glomeruloid structure). Additionally, these tumors often show intracellular and extracellular **alpha-fetoprotein (AFP)** and eosinophilic hyaline globules. 2. **Why Other Options are Incorrect:** * **B. Reed-Sternberg cells:** These are large, multinucleated cells with "owl-eye" nucleoli characteristic of **Hodgkin Lymphoma**. * **C. Reinke's crystals:** These are rod-shaped, eosinophilic cytoplasmic inclusions found in **Leydig cell tumors** of the testis or ovary. * **D. Russell bodies:** These are eosinophilic, immunoglobulin-containing inclusions found in plasma cells, typically seen in **Multiple Myeloma** or chronic inflammation. **High-Yield Clinical Pearls for NEET-PG:** * **Tumor Marker:** Serum **AFP (Alpha-fetoprotein)** is the most important marker for diagnosis and monitoring recurrence. * **Age Group:** Most common malignant germ cell tumor in children (infants/toddlers) [1]. * **Histology:** Look for "lace-like" (reticular) patterns and Schiller-Duval bodies. * **IHC:** Positive for Glypican-3 and AFP. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Lower Urinary Tract and Male Genital System, pp. 979-980.

Question 1

All of the following clinicopathologic features are seen more often in seminomas as compared to non-seminomatous germ cell tumors of the testis except?

Accepted Answer

They are often associated with raised levels of serum AFP and HCG

Answer

Tumors remain localized to testis for a long time

Answer

They are radiosensitive

Answer

They metastasize predominantly by lymphatics

Question 2

Which of the following is a marker for seminoma testis?

Accepted Answer

HCG (Human Chorionic Gonadotropin)

Answer

Alpha-fetoprotein

Answer

Carcinoembryonic antigen

Answer

Acid phosphatase

Question 3

Which of the following are seen in endodermal sinus tumor?

Accepted Answer

Schiller-Duval bodies

Answer

Reed-Sternberg cells

Answer

Reinke's crystals

Answer

Russell bodies

Question 4

Which of the following statements about the Gleason score is NOT true?

Accepted Answer

It is the most important prognostic factor.

Answer

It is used for grading prostatic carcinoma.

Answer

The maximum score is 10.

Answer

The minimum score is 2.

Question 5

BRCA1 gene is responsible for which histological type of breast cancer?

Accepted Answer

Medullary carcinoma

Answer

Tubular carcinoma

Answer

Colloid carcinoma

Answer

Papillary carcinoma

Question 6

A 62-year-old man presents for an annual physical examination. His PSA level is 12.3 ng/dL, and a subsequent prostatic biopsy reveals adenocarcinoma with a Gleason score of 8. The Gleason score is a measurement of:

Accepted Answer

The likelihood that the cancer will grow and spread

Answer

The grade of the cancer based on its cellular appearance

Answer

The stage of the cancer within the prostate gland

Answer

The number of cancer cells expressing prostate specific antigen (PSA)

Question 7

Which of the following types of Human Papillomavirus (HPV) is least associated with cervical malignancy?

Accepted Answer

Type 42

Answer

Type 16

Answer

Type 31

Answer

Type 33

Question 8

All of the following are germ cell tumors except?

Accepted Answer

Leydig cell tumor

Answer

Seminoma

Answer

Embryonal carcinoma

Answer

Endodermal sinus tumor

Question 9

Apoptosis can occur by change in hormone levels in the ovarian cycle. When there is no fertilization of the ovum, the endometrial cells die because:

Accepted Answer

The involution of corpus luteum causes estradiol and progesterone levels to fall dramatically.

Answer

LH levels rise after ovulation.

Answer

Estradiol levels are not involved in the LH surge phenomenon.

Answer

Estradiol inhibits the induction of the progesterone receptor in the endometrium.

Question 10

Which germ cell tumor is associated with elevated Alpha-fetoprotein (AFP)?

Accepted Answer

Yolk sac tumor

Answer

Teratoma

Answer

Choriocarcinoma

Answer

Dysgerminoma

Reproductive Pathology — MCQs

Reproductive Pathology — MCQs

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