Pancreatic Pathology Practice Questions

Q: All of the following statements are true regarding Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, except:

There is the presence of ovarian stroma on histology. **Explanation:** Intraductal Papillary Mucinous Neoplasms (IPMNs) are mucin-producing epithelial neoplasms that arise within the pancreatic ductal system [1]. **Why Option D is the correct answer (The Exception):** The presence of **"ovarian-type subepithelial stroma"** is the pathognomonic histological feature of **Mucinous Cystic Neoplasms (MCNs)**, not IPMNs. MCNs occur almost exclusively in females and are typically located in the tail of the pancreas. IPMNs lack this specialized stroma. **Analysis of Incorrect Options:** * **Option A:** IPMNs most frequently involve the **head of the pancreas** (unlike MCNs, which favor the tail). * **Option B:** IPMNs are recognized **precursor lesions** to invasive pancreatic adenocarcinoma [1]. They follow a progression from low-grade dysplasia to high-grade dysplasia and finally invasive carcinoma. * **Option C:** By definition, IPMNs involve the **larger pancreatic ducts** (either the main pancreatic duct or its major side branches). This distinguishes them from Pancreatic Intraepithelial Neoplasia (PanIN), which involves small microscopic ducts (<5mm). **High-Yield Clinical Pearls for NEET-PG:** * **Demographics:** IPMNs are more common in **men** (unlike MCNs). * **Imaging:** Classically described as a "grape-like" cluster of cysts communicating with the pancreatic duct. * **Key Distinction:** If a question mentions a mucinous cyst in a **female** with **ovarian stroma** and **no ductal communication**, think **MCN**. If it mentions a **male**, the **pancreatic head**, and **ductal communication**, think **IPMN**. * **Markers:** Both IPMN and MCN may show elevated CEA levels in the cyst fluid [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Pancreas, p. 897.

Q: A 1-month-old infant presents with repeated bouts of bilious vomiting over the past month and inadequate feeding. The infant is in the 10th percentile for weight and 50th percentile for length. An upper GI series reveals marked narrowing of the midportion of the duodenum. What is the most likely cause of this infant's gastrointestinal obstruction?

Annular pancreas. ### Explanation **Correct Answer: A. Annular Pancreas** **Mechanism:** Annular pancreas is a congenital anomaly where a ring of pancreatic tissue completely or partially encircles the **second part of the duodenum**. This occurs due to the **failure of the ventral pancreatic bud to rotate properly** behind the duodenum. Instead, the bifid ventral bud migrates in opposite directions, fusing with the dorsal bud and creating a constricting band. This leads to extrinsic duodenal obstruction, typically presenting in infancy with **bilious vomiting** (as the obstruction is usually distal to the ampulla of Vater) and failure to thrive. **Why other options are incorrect:** * **B. Duodenal polyp:** While polyps can cause obstruction, they are extremely rare in neonates and typically present with occult bleeding or intussusception in older children/adults. * **C. Islet cell adenoma:** These are functional neuroendocrine tumors (e.g., insulinomas) that present with metabolic symptoms like hypoglycemia, not mechanical bowel obstruction. * **D. Pancreatic pseudocyst:** These are complications of acute or chronic pancreatitis [1]. They are rare in a 1-month-old and would typically follow a history of trauma or systemic illness. **NEET-PG High-Yield Pearls:** * **Embryology:** Caused by abnormal migration of the **ventral pancreatic bud**. * **Radiology:** Characterized by the **"Double Bubble Sign"** on X-ray (air in the stomach and proximal duodenum), similar to duodenal atresia. * **Associations:** Strongly associated with **Down Syndrome (Trisomy 21)**, duodenal atresia, and malrotation. * **Clinical Presentation:** Can be asymptomatic in adults or present with peptic ulcers due to stasis. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Liver And Biliary System Disease, pp. 407-408.

Q: Which of the following can be used as a tumor marker in pancreatic carcinoma?

CA 19-9. **Explanation:** **CA 19-9 (Carbohydrate Antigen 19-9)** is the most widely used and clinically validated tumor marker for **Pancreatic Adenocarcinoma**. It is a sialylated Lewis (a) blood group antigen. While it lacks the sensitivity and specificity required for population screening, it is invaluable for **monitoring treatment response** and **detecting disease recurrence** following surgical resection. **Analysis of Incorrect Options:** * **CA-125:** This is the primary tumor marker for **Ovarian Cancer** (specifically non-mucinous epithelial tumors). It can also be elevated in endometriosis and pelvic inflammatory disease. * **CA 15-3 & CA 27-29:** These are both markers primarily used to monitor **Breast Cancer**. They are used to track the clinical course of patients with metastatic disease rather than for initial diagnosis. **High-Yield Clinical Pearls for NEET-PG:** 1. **Lewis Antigen Status:** Approximately 5–10% of the population is "Lewis antigen-negative" (Le a-/b-). These individuals lack the enzyme to synthesize CA 19-9; therefore, they will not show elevated levels even in the presence of advanced pancreatic cancer. 2. **Obstructive Jaundice:** CA 19-9 can be falsely elevated in benign conditions like biliary obstruction (cholangitis or gallstones). Levels should be re-evaluated after biliary decompression. 3. **Prognosis:** Very high preoperative levels of CA 19-9 (>1000 U/mL) usually correlate with occult metastatic disease and poor resectability [1]. 4. **Other Markers:** While **CEA** (Carcinoembryonic Antigen) can also be elevated in pancreatic cancer, it is less specific than CA 19-9. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Pancreas, p. 901.

Question 1

What is the most common oncogene involved in pancreatic adenocarcinoma?

Accepted Answer

K-RAS

Answer

P53

Answer

APC

Answer

DCC

Question 2

Which is the least malignant pancreatic endocrine tumor?

Accepted Answer

Insulinoma

Answer

Zollinger-Ellison syndrome

Answer

VIPoma

Answer

Glucagonoma

Question 3

Which of the following is NOT an etiology of pancreatitis?

Accepted Answer

Islet cell hyperplasia

Answer

Abdominal trauma

Answer

Hyperlipidemia

Answer

Germline mutations in the cationic trypsinogen gene

Question 4

Histology for type 2 autoimmune pancreatitis characteristically demonstrates which of the following?

Accepted Answer

Granulocytic epithelial lesion

Answer

IgG4 positive plasma cells > 10/HPF

Answer

Storiform fibrosis

Answer

Microvascular thrombosis

Question 5

A 63-year-old woman presents with a 6-month history of recurrent epigastric pain and nausea. Abdominal ultrasound reveals a 13-mm hypoechoic lesion in the tail of the pancreas. Physical examination shows flushing of the face, periorbital edema, and hypotension. Laboratory studies disclose normal serum levels of gastrin, amylase, insulin, and vasoactive intestinal polypeptide. Urinalysis demonstrates elevated levels of metanephrines. Which of the following is the most likely diagnosis?

Accepted Answer

Pancreatic carcinoid

Answer

Adenocarcinoma of pancreas

Answer

Glucagonoma

Answer

Insulinoma

Question 6

Which of the following is a commonly seen pancreatic endocrine tumor?

Accepted Answer

Insulinoma

Answer

Somatostatinoma

Answer

Gastrinoma

Answer

Glucagonoma

Question 7

All of the following statements are true regarding Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, except:

Accepted Answer

There is the presence of ovarian stroma on histology

Answer

Mainly involve the head of the pancreas

Answer

Are precursor lesions of pancreatic carcinoma

Answer

Usually involve the large ducts of the pancreas

Question 8

A 1-month-old infant presents with repeated bouts of bilious vomiting over the past month and inadequate feeding. The infant is in the 10th percentile for weight and 50th percentile for length. An upper GI series reveals marked narrowing of the midportion of the duodenum. What is the most likely cause of this infant's gastrointestinal obstruction?

Accepted Answer

Annular pancreas

Answer

Duodenal polyp

Answer

Islet cell adenoma

Answer

Pancreatic pseudocyst

Question 9

An important triggering event in acute pancreatitis is activation of?

Accepted Answer

Trypsinogen

Answer

Pepsinogen

Answer

Prekallikrein

Answer

Lipase

Question 10

Which of the following can be used as a tumor marker in pancreatic carcinoma?

Accepted Answer

CA 19-9

Answer

CA-125

Answer

CA 27-29

Answer

CA 15-3

Pancreatic Pathology — MCQs

Pancreatic Pathology — MCQs

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