Molecular Pathology Practice Questions

Q: A 60-year-old asymptomatic female shows the following change in the tunica media of blood vessels. What is the diagnosis?

Medial calcification. ***Medial calcification*** - **Mönckeberg's medial calcific sclerosis** presents as **calcium deposits** in the tunica media, appearing as **basophilic deposits** on H&E staining in elderly patients. - This condition is typically **asymptomatic** and does **not narrow the vessel lumen**, distinguishing it from intimal calcification seen in atherosclerosis. *Medial fibrosis* - Would show **collagen deposition** and **fibroblast proliferation** in the tunica media rather than calcium deposits. - Typically associated with **hypertensive vascular disease** and would appear **eosinophilic** on H&E staining, not basophilic. *Amyloidosis* - Characterized by **Congo red positive** deposits that show **apple-green birefringence** under polarized light. - **Amyloid deposits** would appear as **homogeneous eosinophilic material** on routine H&E staining, not calcium deposits. *None of the above* - The clinical presentation of an **asymptomatic elderly female** with tunica media changes is classic for **Mönckeberg's sclerosis**. - The **basophilic calcium deposits** in the media are pathognomonic for medial calcification, making this the correct diagnosis.

Question 1

Foci of granulomatous inflammation show all of the following except?

Accepted Answer

Eosinophils

Answer

Epithelioid cells

Answer

Fibrosis

Answer

Lymphocytes

Question 2

NKX3-1 immunohistochemistry is used for the diagnosis of which of the following?

Accepted Answer

Prostate carcinoma

Answer

Colorectal carcinoma

Answer

Pancreatic carcinoma

Answer

Renal cell carcinoma

Question 3

Which of the following is considered a major pyrogenic cytokine?

Accepted Answer

Interleukin-1

Answer

Interferon alpha

Answer

Tumor necrosis factor beta

Answer

Interleukin-3

Question 4

A 60-year-old asymptomatic female shows the following change in the tunica media of blood vessels. What is the diagnosis?

Accepted Answer

Medial calcification

Answer

Medial fibrosis

Answer

Amyloidosis

Answer

None of the above

Question 5

What is the primary molecular pathology associated with Marfan syndrome?

Accepted Answer

Fibrillin I

Answer

Fibrillin II

Answer

Collagen

Answer

Elastin

Molecular Pathology — MCQs

Molecular Pathology — MCQs

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