Liver and Biliary Pathology Practice Questions

Q: Primary sinusoidal dilatation of liver is also known as?

Peliosis hepatis. **Explanation:** **Peliosis hepatis** is a rare vascular condition characterized by the **primary dilatation of hepatic sinusoids**, resulting in the formation of irregular, blood-filled cystic spaces within the liver parenchyma. These cysts are typically not lined by endothelium. * **Pathogenesis:** It is most commonly associated with the use of **anabolic steroids**, oral contraceptives, and certain infections (notably **Bartonella henselae** in HIV patients, known as bacillary peliosis). * **Clinical Significance:** While often asymptomatic, it can lead to massive intra-abdominal hemorrhage or liver failure. **Why the other options are incorrect:** * **Hepar lobatum:** This refers to the coarsely scarred, lobulated appearance of the liver seen in **Tertiary Syphilis** due to the healing of multiple gummas. * **Von-Meyenburg Complex:** These are **biliary hamartomas**. They are small, benign clusters of dilated bile ducts embedded in a fibrous stroma, representing a malformation of the ductal plate. * **Caroli’s Disease:** This is a congenital disorder characterized by **segmental dilatation of the intrahepatic bile ducts**. It is part of the spectrum of fibropolycystic liver diseases and is associated with an increased risk of cholangiocarcinoma. **High-Yield Pearls for NEET-PG:** * **Peliosis Hepatis + HIV:** Always think of *Bartonella henselae* (Bacillary Peliosis). * **Drug Association:** Anabolic steroids are the most frequently cited pharmacological cause in exams. * **Gross Appearance:** The liver shows "blood-filled lakes" or a "Swiss cheese" appearance on cross-section.

Question 1

Florid duct lesions are diagnostic of which of the following conditions?

Accepted Answer

Primary biliary cirrhosis

Answer

Klatskin tumor

Answer

Primary sclerosing cholangitis

Answer

Secondary biliary cirrhosis

Question 2

In which cause of jaundice is there no bilirubin excretion in urine?

Accepted Answer

Hemolytic jaundice

Answer

Obstructive jaundice

Answer

Primary biliary cirrhosis

Answer

Extrahepatic biliary atresia

Question 3

Increased risk of liver adenoma is found in which of the following diseases?

Accepted Answer

Glycogen storage disorder

Answer

Lipid storage disorder

Answer

Mitochondrial disease

Answer

Lysosomal storage disorder

Question 4

A 36-year-old man from sub-Saharan Africa presents with jaundice and right upper quadrant pain. On examination, the liver is palpably enlarged. Laboratory studies demonstrate an increase in liver enzymes. Computed tomography demonstrates a single large mass in the right lobe of the liver, and serum a-fetoprotein is markedly elevated. Which of the following is likely to have contributed to the patient's condition?

Accepted Answer

Aflatoxin B1

Answer

Clonorchis sinensis

Answer

Hepatitis A

Answer

Polyvinyl chloride

Question 5

Which one of the following statements is not true regarding fibrolamellar carcinoma?

Accepted Answer

Associated with Hepatitis B virus infection

Answer

Seen in young adults

Answer

Better prognosis than hepatocellular carcinoma

Answer

Elevated alpha-fetoprotein is not seen

Question 6

Chronic alcoholism is associated with the development of all of the following liver diseases, EXCEPT?

Accepted Answer

Granuloma formation

Answer

Cirrhosis

Answer

Fatty degeneration

Answer

Cholestatic hepatitis

Question 7

A 38-year-old man, a chronic alcoholic, presents with pain in the abdomen. On examination, his liver is enlarged and serum alpha-fetoprotein is elevated. What is the most likely diagnosis?

Accepted Answer

Hepatocellular carcinoma

Answer

Liver cell hyperplasia

Answer

Hepatic adenoma

Answer

Hepatitis

Question 8

Which one of the following is not a feature of liver histology in non-cirrhotic portal fibrosis (NCPF)?

Accepted Answer

Bridging fibrosis

Answer

Fibrosis in and around the portal tracts

Answer

Thrombosis of the medium and small portal vein branches

Answer

Non-specific inflammatory cell infiltrates in the portal tracts

Question 9

Multiple liver secondaries are most common in which of the following cancers?

Accepted Answer

Gallbladder cancer

Answer

Pancreatic cancer

Answer

Gastric cancer

Answer

Periampullary cancer

Question 10

Primary sinusoidal dilatation of liver is also known as?

Accepted Answer

Peliosis hepatis

Answer

Hepar lobatum

Answer

Von-Meyerburg complex

Answer

Caroli's disease

Liver and Biliary Pathology — MCQs

Liver and Biliary Pathology — MCQs

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