Liver and Biliary Pathology Practice Questions

Q: Primary sinusoidal dilatation of liver is also known as?

Peliosis hepatis. **Explanation:** **Peliosis hepatis** is a rare vascular condition characterized by the **primary dilatation of hepatic sinusoids**, resulting in the formation of irregular, blood-filled cystic spaces within the liver parenchyma. These cysts are typically not lined by endothelium. * **Pathogenesis:** It is most commonly associated with the use of **anabolic steroids**, oral contraceptives, and certain infections (notably **Bartonella henselae** in HIV patients, known as bacillary peliosis). * **Clinical Significance:** While often asymptomatic, it can lead to massive intra-abdominal hemorrhage or liver failure. **Why the other options are incorrect:** * **Hepar lobatum:** This refers to the coarsely scarred, lobulated appearance of the liver seen in **Tertiary Syphilis** due to the healing of multiple gummas. * **Von-Meyenburg Complex:** These are **biliary hamartomas**. They are small, benign clusters of dilated bile ducts embedded in a fibrous stroma, representing a malformation of the ductal plate. * **Caroli’s Disease:** This is a congenital disorder characterized by **segmental dilatation of the intrahepatic bile ducts**. It is part of the spectrum of fibropolycystic liver diseases and is associated with an increased risk of cholangiocarcinoma. **High-Yield Pearls for NEET-PG:** * **Peliosis Hepatis + HIV:** Always think of *Bartonella henselae* (Bacillary Peliosis). * **Drug Association:** Anabolic steroids are the most frequently cited pharmacological cause in exams. * **Gross Appearance:** The liver shows "blood-filled lakes" or a "Swiss cheese" appearance on cross-section.

Question 1

Mallory hyaline bodies are present in all of the following conditions, except?

Accepted Answer

Secondary biliary cirrhosis

Answer

Primary biliary cirrhosis

Answer

Indian childhood cirrhosis

Answer

Alcoholic cirrhosis

Question 2

Increased risk of liver adenoma is found in which of the following diseases?

Accepted Answer

Glycogen storage disorder

Answer

Lipid storage disorder

Answer

Mitochondrial disease

Answer

Lysosomal storage disorder

Question 3

A 36-year-old man from sub-Saharan Africa presents with jaundice and right upper quadrant pain. On examination, the liver is palpably enlarged. Laboratory studies demonstrate an increase in liver enzymes. Computed tomography demonstrates a single large mass in the right lobe of the liver, and serum a-fetoprotein is markedly elevated. Which of the following is likely to have contributed to the patient's condition?

Accepted Answer

Aflatoxin B1

Answer

Clonorchis sinensis

Answer

Hepatitis A

Answer

Polyvinyl chloride

Question 4

Which one of the following statements is not true regarding fibrolamellar carcinoma?

Accepted Answer

Associated with Hepatitis B virus infection

Answer

Seen in young adults

Answer

Better prognosis than hepatocellular carcinoma

Answer

Elevated alpha-fetoprotein is not seen

Question 5

Chronic alcoholism is associated with the development of all of the following liver diseases, EXCEPT?

Accepted Answer

Granuloma formation

Answer

Cirrhosis

Answer

Fatty degeneration

Answer

Cholestatic hepatitis

Question 6

A 38-year-old man, a chronic alcoholic, presents with pain in the abdomen. On examination, his liver is enlarged and serum alpha-fetoprotein is elevated. What is the most likely diagnosis?

Accepted Answer

Hepatocellular carcinoma

Answer

Liver cell hyperplasia

Answer

Hepatic adenoma

Answer

Hepatitis

Question 7

Which one of the following is not a feature of liver histology in non-cirrhotic portal fibrosis (NCPF)?

Accepted Answer

Bridging fibrosis

Answer

Fibrosis in and around the portal tracts

Answer

Thrombosis of the medium and small portal vein branches

Answer

Non-specific inflammatory cell infiltrates in the portal tracts

Question 8

Multiple liver secondaries are most common in which of the following cancers?

Accepted Answer

Gallbladder cancer

Answer

Pancreatic cancer

Answer

Gastric cancer

Answer

Periampullary cancer

Question 9

Primary sinusoidal dilatation of liver is also known as?

Accepted Answer

Peliosis hepatis

Answer

Hepar lobatum

Answer

Von-Meyerburg complex

Answer

Caroli's disease

Question 10

Which virus, besides HBV, is implicated in hepatocellular carcinoma?

Accepted Answer

Hepatitis C virus (HCV)

Answer

Herpes simplex virus

Answer

Hepatitis A virus (HAV)

Answer

Hepatitis E virus (HEV)

Liver and Biliary Pathology — MCQs

Liver and Biliary Pathology — MCQs

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