Inflammation and Repair Practice Questions

Q: The morphological pattern of inflammation shown here is:

Serous. ***Serous*** - Characterized by **watery, protein-poor fluid** with minimal cellular content, typically seen in **blisters** and **vesicles**. - Classic example includes **skin blisters** from burns or allergic reactions, where clear fluid accumulates in tissue spaces. *Fibrinous* - Features **fibrin strands** and **fibrin deposits** creating a mesh-like appearance on tissue surfaces. - Commonly seen in **pericarditis** and **pleuritis**, where fibrin forms a "bread-and-butter" appearance on organ surfaces. *Purulent* - Contains abundant **neutrophils** and **pus formation** with thick, yellowish inflammatory exudate. - Typical of **bacterial infections** like abscesses, where neutrophil infiltration dominates the inflammatory response. *Chronic* - Dominated by **lymphocytes**, **macrophages**, and **plasma cells** rather than acute inflammatory cells. - Develops over **weeks to months** and often involves **tissue destruction** and **fibrosis** formation.

Question 1

A 29-year-old carpenter receives a traumatic laceration to her left arm. Which of the following is the most important factor that determines whether this wound will heal by primary or secondary intention?

Accepted Answer

Apposition of edges

Answer

Depth of wound

Answer

Metabolic status

Answer

Skin site affected

Question 2

The morphological pattern of inflammation shown here is:

Accepted Answer

Serous

Answer

Fibrinous

Answer

Purulent

Answer

Chronic

Question 3

Provisional matrix is made up of which of the following components?

Accepted Answer

All of the above

Answer

Fibrin

Answer

Fibronectin

Answer

Fibrinogen

Question 4

What is the primary type of collagen found in early granulation tissue?

Accepted Answer

Type I and IV collagen

Answer

Type I collagen

Answer

Type IV collagen

Answer

None of the above

Question 5

Which of the following statements regarding keloid formation is true?

Accepted Answer

Keloids exhibit increased collagen deposition and vascularity.

Answer

Keloids are characterized by normal levels of growth factors.

Answer

Surgical excision is the primary treatment for keloids.

Answer

Keloid tissue typically remains confined to the original wound site.

Question 6

Which of the following is NOT seen in the inflammatory stage of wound healing?

Accepted Answer

Angiogenesis

Answer

Chemotaxis

Answer

Increased vessel permeability

Answer

Release of cytokines and chemokines

Question 7

Which of the following statements regarding primary intentional healing is true?

Accepted Answer

Neovascularization is maximum by day 5.

Answer

Neovascularization is maximum by day 3.

Answer

Neutrophils appear at wound margins on day 3.

Answer

The epidermis recovers its maximum thickness by day 7.

Question 8

In healing by first intention, all of the following occur EXCEPT?

Accepted Answer

New collagen can be seen earliest by the 8 to 10 days.

Answer

A continuous layer of epidermis forms within 48 hours.

Answer

Reticulin can be demonstrated in the dermal gap by the 2nd to 3rd day.

Answer

By the 4th week, the cellular and vascular elements decrease in number and concentration.

Question 9

Which of the following is NOT an action of TGF-beta?

Accepted Answer

Anaphylaxis

Answer

Anti-inflammatory effects

Answer

Proliferation of fibrous tissue

Answer

Inhibition of metalloproteinases

Question 10

Which of the following chemical mediators of inflammation is an example of a C-X-C or alpha chemokine?

Accepted Answer

Interleukin IL-8

Answer

Lipoxin LXA4

Answer

Interleukin IL-6

Answer

Monocyte Chemoattractant Protein MCP-1

Inflammation and Repair — MCQs

Inflammation and Repair — MCQs

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