Acute Inflammation: Cellular Events Practice Questions

Question 1

Which of the following helps in cell-to-cell adhesion?

Accepted Answer

E-Cadherin

Answer

Interleukins

Answer

Interferons

Answer

Matrix metalloproteinases

Question 2

Most effective bactericidal system within phagocytes is-

Accepted Answer

Reactive oxygen metabolite mediated

Answer

Cationic basic protein mediated

Answer

Lysozyme mediated

Answer

Lactoferrin mediated

Question 3

A major step in the pathogenesis of listeriosis is?

Accepted Answer

The survival and multiplication of L. monocytogenes within mononuclear phagocytes and host epithelial cells

Answer

The antiphagocytic activity of the L. monocytogenes capsule

Answer

The release of hyaluronidase by L. monocytogenes, which contributes to its dissemination from local sites

Answer

The formation of antigen-antibody complexes with resultant complement activation and tissue damage

Question 4

A patient with chronic granulomatous disease is most likely to have a defect in which enzyme?

Accepted Answer

NADPH oxidase

Answer

Superoxide dismutase

Answer

Catalase

Answer

Myeloperoxidase

Question 5

What is the main feature of chemotaxis as observed in white blood cells?

Accepted Answer

Unidirectional locomotion of neutrophils

Answer

Increased random movement of neutrophils

Answer

Increased adhesiveness to intima

Answer

Increased phagocytosis

Question 6

Arrange the following cellular events of inflammation in the correct sequence:

1. Rolling
2. Cytokine-mediated integrin activation
3. Adhesion
4. Migration

Accepted Answer

1,2,3,4

Answer

3,4,1,2

Answer

2,1,4,3

Answer

4,1,2,3

Question 7

Increased vascular permeability in acute inflammation is due to what?

Accepted Answer

Histamine

Answer

IL-2

Answer

TGF-β

Answer

FGF-2

Question 8

Which of the following is/are characteristic features of chronic inflammation?

Accepted Answer

Tissue fibrosis and lymphocyte infiltration

Answer

Infiltration of neutrophils

Answer

Increased blood flow (hyperemia)

Answer

Presence of fluid accumulation (edema) in tissues

Question 9

Which of the following statements about C-reactive protein (CRP) is true?

Accepted Answer

It is raised in acute pneumococcal infection.

Answer

It is detected by agglutination test.

Answer

It is an antibody.

Answer

It is detected by precipitation with carbohydrate.

Question 10

Which statement about macrophages is incorrect?

Accepted Answer

M2 type involved in inflammation

Answer

Phagocytic cells

Answer

Activation by IFN-γ

Answer

Major cells in chronic inflammation

Acute Inflammation: Cellular Events — MCQs

Acute Inflammation: Cellular Events — MCQs

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