Immunopathology — MCQs

Type 4 hypersensitivity to Mycobacterium tuberculosis antigen may manifest as?

Anti-endothelial antibodies are seen in which of the following conditions?

A 26-year-old man has had myalgias and a fever for the past week. On physical examination, his temperature is 38.6°C. He has diffuse muscle tenderness, but no rashes or joint pain on movement. Laboratory studies show elevated serum creatine kinase and peripheral blood eosinophilia. Larvae of Trichinella spiralis are present within the skeletal muscle fibers of a gastrocnemius biopsy specimen. Two years later, a chest radiograph shows only a few small calcifications in the diaphragm. Which of the following immunologic mechanisms most likely contributed to the destruction of the larvae?

Which immunoglobulin combination is predominantly involved in the pathogenesis of cryoglobulinemic vasculitis?

A 30-year-old lady presents to the outpatient department with an erythematous butterfly rash on her cheeks. Which of the following antibodies should be assayed initially for her suspected condition?

Which part of the IgE antibody is responsible for binding to mast cells and basophils?

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism by which target cells are killed. Which immune cells are primarily involved in ADCC?

A 30-year-old male develops tachycardia, hypotension (BP 70/40 mm Hg), and hematuria within 10 minutes of starting a blood transfusion in the OT. What is the most probable cause?

Which condition has a >90% association with HLA-B27?

Extranodal marginal zone lymphomas of MALT type can involve the thymus in the setting of which of the following conditions?