Immunopathology — MCQs

Which of the following is characteristic of Graft-versus-Host Disease (GVHD)?

Pinch purpura is seen in which of the following conditions?

Which cells mediate Type IV hypersensitivity reactions?

C-ANCA positivity indicates antibody formation against which of the following?

Which of the following is an example of Type 3 hypersensitivity?

A 14-month-old child has had multiple infections since birth, including pneumonia with Pseudomonas aeruginosa, adenovirus, and Aspergillus fumigatus; diarrhea with Isospora belli; otitis media with Haemophilus influenzae; and urinary tract infection with Candida albicans. Laboratory studies show hemoglobin, 13.2 g/dL; hematocrit, 39.7%; platelet count, 239,100/mm3; and WBC count, 3450/mm3 with 85% segmented neutrophils, 6% bands, 2% lymphocytes, and 7% monocytes. Serum immunoglobulin levels are IgG, 118 mg/dL; IgM, 14 mg/dL; and IgA, 23 mg/dL. The child dies of pneumonia. At autopsy, a hypoplastic thymus, small lymph nodes that lack germinal centers, and scant gut-associated lymphoid tissue are seen. Which of the following is the most likely cause of this disease?

Which Human Leukocyte Antigen (HLA) class is associated with CD4?

What condition is indicated by a lymphocyte phenotype test?

All of the following are involved in graft-versus-host disease except?

Hypersensitivity pneumonitis is classically described as which type of hypersensitivity reaction?