Hematopathology Practice Questions

Q: What is the common name for coagulation factor VII?

Proconvertin. **Explanation:** Coagulation Factor VII is a vitamin K-dependent serine protease synthesized in the liver [1]. It plays a pivotal role in the **extrinsic pathway** of the coagulation cascade. **1. Why Proconvertin is correct:** Factor VII is commonly known as **Proconvertin** (or Serum Prothrombin Conversion Accelerator - SPCA). It is activated by Tissue Factor (Factor III) to form Factor VIIa. This complex then activates Factor X into Xa, serving as the primary initiator of the coagulation process in vivo. **2. Analysis of Incorrect Options:** * **Option A: Thromboplastin:** This is the common name for **Factor III** (Tissue Factor). It is released from damaged vascular endothelial cells to initiate the extrinsic pathway. * **Option B: Accelerin:** This refers to **Factor Va**. Factor V is known as Proaccelerin (labile factor); once activated by thrombin, it becomes Accelerin (Va), acting as a cofactor in the prothrombinase complex. * **Option C: Antihemophilic factor (AHF):** This is the common name for **Factor VIII**. A deficiency in this factor leads to Hemophilia A. **High-Yield Clinical Pearls for NEET-PG:** * **Shortest Half-life:** Factor VII has the shortest half-life (approx. 4–6 hours) among all coagulation factors. * **Warfarin Monitoring:** Because of its short half-life, Factor VII is the first factor to decrease when starting Warfarin therapy [1]. This is why the **Prothrombin Time (PT/INR)** is used to monitor extrinsic pathway activity and early Warfarin effect. * **Vitamin K Dependency:** Factors II, VII, IX, and X (and Proteins C and S) are all Vitamin K-dependent [1]. * **Factor VII Deficiency:** A rare autosomal recessive bleeding disorder that presents with a prolonged PT but a normal aPTT. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Blood And Bone Marrow Disease, pp. 582-583.

Question 1

Examination of a peripheral blood smear demonstrates a leukemia composed of small mature lymphocytes without blast forms. Which of the following is the most likely age of this patient?

Accepted Answer

65 years

Answer

1 year

Answer

45 years

Answer

5 years

Question 2

Golf ball inclusion bodies in RBCs are seen in which condition?

Accepted Answer

HbH disease

Answer

Normal reticulocytes

Answer

Pernicious anaemia

Answer

G6PD deficiency

Question 3

D-Dimer values may be increased in all of the following conditions except?

Accepted Answer

Anticoagulant therapy

Answer

Myocardial infarction

Answer

Pneumonia

Answer

Pregnancy

Question 4

What is the common name for coagulation factor VII?

Accepted Answer

Proconvertin

Answer

Thromboplastin

Answer

Accelerin

Answer

Antihemophilic factor

Question 5

Which of the following findings is NOT compatible with a diagnosis of chronic myelomonocytic leukemia?

Accepted Answer

More than 20% blasts in blood or bone marrow

Answer

Absence of Philadelphia chromosome

Answer

Both absence of Philadelphia chromosome and more than 20% blasts in blood or bone marrow

Answer

None of the above

Question 6

A patient presents with anemia and peripheral blood smear findings suggestive of thalassemia. A positive family history is also noted. Which investigation is essential to establish the diagnosis?

Accepted Answer

Hemoglobin (Hb) electrophoresis

Answer

Erythrocyte Sedimentation Rate (ESR) estimation

Answer

Blood spherocyte estimation

Answer

Bone marrow aspiration

Question 7

Maturation defect of RBCs is seen in which of the following conditions?

Accepted Answer

Vitamin B12 deficiency

Answer

Vitamin B6 deficiency

Answer

Iron deficiency

Answer

Protein deficiency

Question 8

Which of the following findings is seen in megaloblastic anemia?

Accepted Answer

All of the above

Answer

Howell-Jolly bodies

Answer

Cabot rings

Answer

Basophilic stippling

Question 9

Macrocytic anemia is seen in all of the following conditions EXCEPT:

Accepted Answer

Anemia of chronic disease

Answer

Vitamin B12 deficiency

Answer

Hemolytic anemia

Answer

Post hemorrhagic anemia

Question 10

Which among the following is the best laboratory test to estimate iron stores in the body?

Accepted Answer

Ferritin

Answer

Transferrin

Answer

Serum iron

Answer

Hemoglobin

Hematopathology — MCQs

Hematopathology — MCQs

On this page

Practice by Chapter

Want unlimited practice?