Hematopathology Practice Questions

Q: Duffy antigen is associated with which Cluster of Differentiation?

CD234. The **Duffy antigen**, also known as the Duffy Antigen Receptor for Chemokines (DARC), is a glycoprotein expressed on the surface of red blood cells (RBCs) and endothelial cells. In the Cluster of Differentiation (CD) nomenclature, it is designated as **CD234**. **1. Why CD234 is Correct:** CD234 acts as a multi-ligand receptor for various chemokines. Its primary clinical significance in hematopathology lies in its role as the portal of entry for **Plasmodium vivax** merozoites [1]. Individuals who are "Duffy-negative" (Fy a-b-) lack this receptor on their RBCs, providing them with natural resistance against *P. vivax* malaria. This phenotype is highly prevalent in West African populations. **2. Analysis of Incorrect Options:** * **CD123:** This is the **IL-3 receptor alpha chain**. It is a high-yield marker for **Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)** and is also expressed in Hairy Cell Leukemia. * **CD345 and CD456:** These are **distractor options**. The current CD nomenclature officially extends to approximately CD371. Numbers in the 300s and 400s are either recently assigned or do not exist in standard medical curricula, making them common "filler" options in competitive exams. **Clinical Pearls for NEET-PG:** * **Malaria Link:** Duffy-negative status protects against *P. vivax* but **not** *P. falciparum* [1]. * **Chemokine Sink:** CD234 on endothelial cells acts as a "sink" to clear inflammatory chemokines from circulation. * **Genetics:** The Duffy gene is located on **Chromosome 1**. * **Transfusion Medicine:** Anti-Fya and Anti-Fyb antibodies are clinically significant and can cause Delayed Hemolytic Transfusion Reactions (DHTR). **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Infectious Diseases, pp. 398-400.

Question 1

Which of the following conditions is characterized by a "punched-out" appearance in the skull?

Accepted Answer

Multiple myeloma

Answer

Thalassemia

Answer

Carcinoma of the lung

Answer

Hyperparathyroidism

Question 2

Neoplastic cells with multilobulated nuclei ('clover leaf' or flower cells) are seen in which of the following?

Accepted Answer

Adult T-cell leukemia (ATLL)

Answer

Diffuse large B cell lymphoma (DLBCL)

Answer

Anaplastic large cell lymphoma (ALCL)

Answer

Mycosis fungoides

Question 3

The t(9;22)(q34;q11) translocation is commonly associated with which of the following conditions?

Accepted Answer

Chronic Myeloid Leukemia (CML)

Answer

Acute Myeloid Leukemia (AML)

Answer

Acute Lymphoblastic Leukemia (ALL)

Answer

Chronic Lymphocytic Leukemia (CLL)

Question 4

Which of the following is NOT typically seen in Hemophilia A?

Accepted Answer

Prolonged PT

Answer

Decreased Factor VIII

Answer

Prolonged PTT

Answer

Normal Bleeding Time

Question 5

All are important laboratory features of hemolytic anemia, EXCEPT:

Accepted Answer

Normal AST

Answer

Elevated urobilinogen in stool

Answer

Reduced haptoglobin

Answer

Macrocytes in blood smear

Question 6

Duffy antigen is associated with which Cluster of Differentiation?

Accepted Answer

CD234

Answer

CD123

Answer

CD345

Answer

CD456

Question 7

Which of the following is a low-grade non-Hodgkin lymphoma?

Accepted Answer

Follicular

Answer

Large cell

Answer

Diffuse large cell

Answer

Lymphoblastic

Question 8

Which chromosomal translocation is characteristic of Chronic Myeloid Leukemia (CML)?

Accepted Answer

t(9;22)

Answer

t(2;08)

Answer

t(8;14)

Answer

t(15;17)

Question 9

A 63-year-old man presented with massive splenomegaly, lymphadenopathy, and a total leukocyte count of 17,000 per mm³. Flow cytometry showed CD23-negative and CD5-positive monoclonal B-cells with bright kappa positivity, comprising 80% of the peripheral blood lymphoid cells. What is the most likely diagnosis?

Accepted Answer

Mantle cell lymphoma

Answer

Splenic lymphoma with villous lymphocytes

Answer

Follicular lymphoma

Answer

Hairy cell leukemia

Question 10

Basophilic stippling is seen in which of the following cells?

Accepted Answer

RBCs

Answer

Eosinophils

Answer

Basophils

Answer

Neutrophils

Hematopathology — MCQs

Hematopathology — MCQs

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