Hematopathology Practice Questions

Q: What is the most common type of Non-Hodgkin lymphoma?

Diffuse large B-cell lymphoma. **Explanation:** **Diffuse Large B-cell Lymphoma (DLBCL)** is the most common type of Non-Hodgkin Lymphoma (NHL) worldwide, accounting for approximately **30–40%** of all adult cases. It is characterized by a diffuse growth pattern of large, atypical B-cells (at least twice the size of a normal lymphocyte) that express pan-B-cell markers like CD19, CD20, and CD79a [1]. Clinically, it is an aggressive (high-grade) lymphoma that presents as a rapidly enlarging mass, often involving extranodal sites [1]. **Analysis of Incorrect Options:** * **B. Follicular Lymphoma:** This is the second most common NHL overall (approx. 20%) and the most common **indolent** (low-grade) lymphoma [2]. It is characterized by the t(14;18) translocation involving the *BCL2* gene [2]. * **C. Anaplastic Large-Cell Lymphoma (ALCL):** This is a rare T-cell lymphoma characterized by "hallmark cells" (kidney-shaped nuclei) and CD30 positivity. It represents only a small fraction of NHL cases. * **D. Large T-cell Leukemia/Lymphoma:** T-cell lymphomas are significantly less common than B-cell lymphomas, making up only about 10–15% of all NHL cases. **High-Yield Clinical Pearls for NEET-PG:** * **Most common NHL in children:** Burkitt Lymphoma or Lymphoblastic Lymphoma (DLBCL is rare in children). * **Most common site for extranodal NHL:** Stomach (often MALToma or DLBCL) [1]. * **IHC Profile of DLBCL:** Positive for CD20, CD45, and often BCL6 [2]. * **Prognosis:** While aggressive, DLBCL is potentially curable with the R-CHOP chemotherapy regimen [2]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus, pp. 604-605. [2] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Diseases Of The Urinary And Male Genital Tracts, pp. 563-564.

Question 1

Acid phosphatase is specific to which of the following cells?

Accepted Answer

Monocyte

Answer

T lymphocyte

Answer

B lymphocyte

Answer

Myelocytes

Question 2

All the following diseases contain abnormal immunoglobulin except:

Accepted Answer

Reactive arthritis

Answer

Multiple myeloma

Answer

Seligman's disease

Answer

Franklin's disease

Question 3

Which substance precipitates at 50 to 60 degrees Celsius but disappears on further heating?

Accepted Answer

Light chain.

Answer

Heavy chain.

Answer

Both heavy and light chains.

Answer

Neither heavy nor light chains.

Question 4

Which of the following statements is FALSE regarding the cytochemistry of Acute Myeloid Leukemia (AML)?

Accepted Answer

Periodic Acid-Schiff (PAS) stain is negative in erythroleukemia.

Answer

Myeloperoxidase and Sudan Black stains are positive.

Answer

Non-specific esterase is positive in M4 and M5 subtypes.

Answer

All the above statements are false.

Question 5

Which of the following human malignancies is highly malignant, rapidly progressive, and where a delay in treatment of even 1-2 days can lead to death?

Accepted Answer

Burkitt's lymphoma

Answer

Hodgkin's lymphoma

Answer

Neuroblastoma

Answer

Mycosis fungoides

Question 6

What is the CD marker of MALT lymphoma?

Accepted Answer

CD 20

Answer

CD 3

Answer

CD 5

Answer

CD 40

Question 7

Richter's transformation is associated with which of the following conditions?

Accepted Answer

Chronic Lymphocytic Leukemia (CLL)

Answer

Chronic Myeloid Leukemia (CML)

Answer

Acute Myeloid Leukemia (AML)

Answer

Acute Lymphoblastic Leukemia (ALL)

Question 8

Incompatible blood transfusion leads to all except?

Accepted Answer

Increased plasma prothrombin

Answer

Increased plasma bilirubin

Answer

Jaundice

Answer

Renal failure

Question 9

What is the most common type of Non-Hodgkin lymphoma?

Accepted Answer

Diffuse large B-cell lymphoma

Answer

Follicular lymphoma

Answer

Anaplastic large-cell lymphoma

Answer

Large T-cell leukemia/lymphoma

Question 10

Which of the following statements about Sickle cell anemia is INCORRECT?

Accepted Answer

It is caused by the deletion of a gene.

Answer

It is commonly seen in people of African descent.

Answer

Red blood cell size is typically altered.

Answer

There is a substitution of valine for glutamic acid in the beta-globin chain.

Hematopathology — MCQs

Hematopathology — MCQs

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