Hematopathology — MCQs

A 22-year-old male presents with fatigue, recurrent fever, and enlarged cervical lymph nodes. Peripheral blood smear shows numerous atypical lymphocytes. A biopsy of an enlarged lymph node reveals expansion of lymphoid follicles with preserved underlying architecture, and numerous atypical lymphocytes in the paracortical areas. What is the most likely diagnosis?

Which of the following may present with isolated prolongation of prothrombin time (PT)?

Hydrops fetalis due to Hb Barts is associated with which of the following?

A 40-year-old woman complains of fatigue and nausea of 3 months in duration. Physical examination reveals numerous pustules on the face, as well as splenomegaly and hepatomegaly. Laboratory studies show hemoglobin of 6.3 g/dL and platelets of 50,000/mL. A peripheral smear shows malignant cells with Auer rods. The patient develops diffuse purpura, bleeding from the gums, and laboratory features of disseminated intravascular coagulation (DIC). Which of the following is the appropriate diagnosis?

A patient presented with fever, night sweats, and weight loss. Clinical examination revealed painless lymphadenopathy. Microscopy shows Reed Sternberg cells. What is the most likely condition?

A mother is diagnosed with sickle cell disease, and her husband is normal. What are the chances of having children with sickle cell disease and sickle cell trait, respectively?

Paroxysmal nocturnal hemoglobinuria (PNH) occurs due to a defect in which of the following?

A peripheral smear shows hypersegmented neutrophils. This finding is most likely due to a deficiency of which of the following?

Bone marrow plasmacytosis in multiple myeloma is characteristically more than:

CD-15 helps in the assessment of which of the following?