Hematopathology Practice Questions

Q: The peripheral blood smear shown in the image is most suggestive of which of the following conditions?

Multiple myeloma. ***Multiple myeloma*** - **Rouleaux formation** (red blood cells stacked like coins) is the hallmark finding on peripheral blood smear, caused by increased plasma proteins. - Associated with **hypercalcemia**, **bone lesions**, and **monoclonal protein** (M-spike) on serum electrophoresis. *Hodgkin's lymphoma* - Diagnosis requires identification of **Reed-Sternberg cells** on lymph node biopsy, not peripheral blood smear findings. - Peripheral blood smear typically shows **reactive lymphocytes** and **eosinophilia**, but not rouleaux formation. *Burkitt's lymphoma* - Characterized by **starry-sky pattern** on tissue biopsy with **tingible body macrophages** scattered among malignant B-cells. - Peripheral blood smear may show **blast cells** but lacks the characteristic rouleaux formation seen in multiple myeloma. *Leukemia* - Peripheral blood smear typically shows increased **blast cells** (immature white blood cells) rather than rouleaux formation. - Associated findings include **thrombocytopenia**, **anemia**, and **leukocytosis** with abnormal cell morphology.

Question 1

Aplastic anemia is seen in all of the following conditions EXCEPT?

Accepted Answer

Hepatitis A infection

Answer

Paroxysmal nocturnal hemoglobinuria

Answer

Chloramphenicol therapy

Answer

Human immunodeficiency virus infection

Question 2

Which immunohistochemical marker is most useful in differentiating thymoma from acute lymphoblastic leukemia (ALL)?

Accepted Answer

Cytokeratin

Answer

CD1a

Answer

CD3

Answer

TdT

Question 3

A 6-year-old Afroamerican boy presented with abdominal pain, chronic hemolysis, and abnormal RBC shape on peripheral smear. What is the most likely underlying molecular disorder responsible for this condition?

Accepted Answer

Point mutation

Answer

Trinucleotide repeat

Answer

Antibody against RBC membrane

Answer

Genomic imprinting

Question 4

Which of the following is not a B cell lymphoma?

Accepted Answer

Mycosis fungoides

Answer

CLL (Chronic Lymphocytic Leukemia)

Answer

Hairy cell leukemia

Answer

Mantle cell lymphoma

Question 5

Down syndrome predisposes to which type of cancer?

Accepted Answer

Acute Myeloid Leukemia (AML)

Answer

Chronic Myeloid Leukemia (CML)

Answer

Acute Lymphoblastic Leukemia (ALL)

Answer

Chronic Lymphocytic Leukemia (CLL)

Question 6

The peripheral blood smear shown in the image is most suggestive of which of the following conditions?

Accepted Answer

Multiple myeloma

Answer

Hodgkin’s lymphoma

Answer

Burkitt’s lymphoma

Answer

Leukemia

Question 7

Which virus is most commonly associated with Burkitt's lymphoma?

Accepted Answer

Epstein-Barr virus (EBV)

Answer

Human Herpesvirus (HHV)

Answer

Human Immunodeficiency Virus (HIV)

Answer

Human T-lymphotropic virus (HTLV)

Question 8

Which of the following can cause eosinophilia?

Accepted Answer

Miliary tuberculosis

Answer

Hodgkin's disease

Answer

Filariasis

Answer

HIV infection

Question 9

Peripheral blood smear examination of a post-splenectomy patient would show the presence of which of the following?

Accepted Answer

Howell-Jolly bodies

Answer

Dohle bodies

Answer

Hypersegmented neutrophils

Answer

Spherocytes

Question 10

What is the most common mutation in hemophilia?

Accepted Answer

Intron 22 inversion

Answer

Intron 1 inversion

Answer

619 bp deletion

Answer

3.7 kb deletion

Hematopathology — MCQs

Hematopathology — MCQs

On this page

Practice by Chapter

Want unlimited practice?