Hematopathology Practice Questions

Q: The peripheral blood smear shown in the image is most suggestive of which of the following conditions?

Multiple myeloma. ***Multiple myeloma*** - **Rouleaux formation** (red blood cells stacked like coins) is the hallmark finding on peripheral blood smear, caused by increased plasma proteins. - Associated with **hypercalcemia**, **bone lesions**, and **monoclonal protein** (M-spike) on serum electrophoresis. *Hodgkin's lymphoma* - Diagnosis requires identification of **Reed-Sternberg cells** on lymph node biopsy, not peripheral blood smear findings. - Peripheral blood smear typically shows **reactive lymphocytes** and **eosinophilia**, but not rouleaux formation. *Burkitt's lymphoma* - Characterized by **starry-sky pattern** on tissue biopsy with **tingible body macrophages** scattered among malignant B-cells. - Peripheral blood smear may show **blast cells** but lacks the characteristic rouleaux formation seen in multiple myeloma. *Leukemia* - Peripheral blood smear typically shows increased **blast cells** (immature white blood cells) rather than rouleaux formation. - Associated findings include **thrombocytopenia**, **anemia**, and **leukocytosis** with abnormal cell morphology.

Question 1

Absolute lymphocytosis is seen in which of the following conditions?

Accepted Answer

Tuberculosis (TB)

Answer

Systemic Lupus Erythematosus (SLE)

Answer

Chronic Lymphocytic Leukemia (CLL)

Answer

Brucellosis

Question 2

A female with recurrent abortion and isolated prolonged APTT is most likely associated with which of the following?

Accepted Answer

Lupus anticoagulant

Answer

Disseminated intravascular coagulation (DIC)

Answer

Von Willebrand disease

Answer

Hemophilia

Question 3

Aplastic anemia is seen in all of the following conditions EXCEPT?

Accepted Answer

Hepatitis A infection

Answer

Paroxysmal nocturnal hemoglobinuria

Answer

Chloramphenicol therapy

Answer

Human immunodeficiency virus infection

Question 4

Haptoglobin levels are decreased in which of the following conditions?

Accepted Answer

All of the above

Answer

Mismatched transfusion reactions

Answer

Thalassemia

Answer

G6PD deficiency

Question 5

Which immunohistochemical marker is most useful in differentiating thymoma from acute lymphoblastic leukemia (ALL)?

Accepted Answer

Cytokeratin

Answer

CD1a

Answer

CD3

Answer

TdT

Question 6

A 6-year-old Afroamerican boy presented with abdominal pain, chronic hemolysis, and abnormal RBC shape on peripheral smear. What is the most likely underlying molecular disorder responsible for this condition?

Accepted Answer

Point mutation

Answer

Trinucleotide repeat

Answer

Antibody against RBC membrane

Answer

Genomic imprinting

Question 7

Which of the following is false regarding Transfusion-Related Acute Lung Injury (TRALI)?

Accepted Answer

All of the above

Answer

It is due to the release of mediators from neutrophils in the lungs.

Answer

It occurs within 6 hours of transfusion.

Answer

It occurs more commonly when the donor is a multiparous woman.

Question 8

Which of the following is not a B cell lymphoma?

Accepted Answer

Mycosis fungoides

Answer

CLL (Chronic Lymphocytic Leukemia)

Answer

Hairy cell leukemia

Answer

Mantle cell lymphoma

Question 9

Down syndrome predisposes to which type of cancer?

Accepted Answer

Acute Myeloid Leukemia (AML)

Answer

Chronic Myeloid Leukemia (CML)

Answer

Acute Lymphoblastic Leukemia (ALL)

Answer

Chronic Lymphocytic Leukemia (CLL)

Question 10

The peripheral blood smear shown in the image is most suggestive of which of the following conditions?

Accepted Answer

Multiple myeloma

Answer

Hodgkin’s lymphoma

Answer

Burkitt’s lymphoma

Answer

Leukemia

Hematopathology — MCQs

Hematopathology — MCQs

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