Hematopathology Practice Questions

Q: A 45-year-old male presents with bony pain, with no history of trauma or drug abuse. Investigations revealed an ESR of 140 mm/hr and Hb of 6 gm/dL. A peripheral smear is shown below. What type of chromosomal abnormality is associated with a favorable prognosis in this patient?

t(11;14). ***t(11;14)*** - This translocation involves **CCND1 gene** overexpression and is associated with **standard/favorable risk** in multiple myeloma prognostic stratification. - Patients with t(11;14) typically have **better overall survival** and **response to treatment** compared to other high-risk translocations. *t(14;16)* - This translocation involves the **MAF oncogene** and is classified as **high-risk** by International Myeloma Working Group (IMWG) criteria. - Associated with **poor prognosis**, **aggressive disease course**, and **shorter overall survival** in multiple myeloma patients. *t(4;14)* - This translocation results in **FGFR3** and **MMSET gene** dysregulation and is considered **high-risk** cytogenetics. - Patients typically have **poor prognosis** with **reduced progression-free survival** and **overall survival** rates. *Loss of 13q14* - This chromosomal deletion is associated with **intermediate to poor prognosis** when present as monosomy 13 or del(13q). - Often occurs in conjunction with other **high-risk cytogenetic abnormalities** and contributes to **adverse outcomes** in multiple myeloma.

Question 1

Prolonged prothrombin time is seen in which of the following conditions?

Accepted Answer

Factor VII deficiency

Answer

Haemophilia A

Answer

Haemophilia B

Answer

Thrombocytopenia

Question 2

What is the most common extranodal site for non-Hodgkin's lymphoma?

Accepted Answer

Stomach

Answer

Liver

Answer

Spleen

Answer

Brain

Question 3

Leukemoid reaction is seen in which of the following conditions?

Accepted Answer

Bronchogenic carcinoma

Answer

Acute infection

Answer

Myelomatosis

Answer

Hemorrhage

Question 4

Regarding G6PD deficiency, which of the following is true?

Accepted Answer

Bite cells are positive.

Answer

It is an autosomal dominant disorder.

Answer

It protects against kala azar.

Answer

The enzyme level is directly proportional to the age of RBC.

Question 5

ALL L3 cells resemble which of the following?

Accepted Answer

Burkitt's lymphoma

Answer

Mantle cell lymphoma

Answer

Hodgkin's lymphoma

Answer

Follicular lymphoma

Question 6

ALL, morphology, is a malignancy arising from which cell lineage?

Accepted Answer

Mixed B cell & T cell

Answer

Mature B cell

Answer

Precursor B cell

Answer

Immature T cell

Question 7

What is a common complication seen in polycythemia vera?

Accepted Answer

Myelofibrosis

Answer

Infection

Answer

Hemolysis

Answer

Renal failure

Question 8

Which of the following is the binding site for the von Willebrand factor multimers on the platelets?

Accepted Answer

Glycoprotein 1b

Answer

ADP

Answer

Factor VIII

Answer

Thromboxane A2

Question 9

A 45-year-old male presents with bony pain, with no history of trauma or drug abuse. Investigations revealed an ESR of 140 mm/hr and Hb of 6 gm/dL. A peripheral smear is shown below. What type of chromosomal abnormality is associated with a favorable prognosis in this patient?

Accepted Answer

t(11;14)

Answer

t(14;16)

Answer

t(4;14)

Answer

Loss of 13q14

Question 10

Which of the following disorders has the potential to develop myeloid leukemia?

Accepted Answer

Paroxysmal nocturnal Hemoglobinuria

Answer

Microangiopathic hemolytic anemia

Answer

Sideroblastic anemia

Answer

Megaloblastic anemia

Hematopathology — MCQs

Hematopathology — MCQs

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