Hematopathology — MCQs

A 6-month-old infant presents with Hb of 6 gm% and features of anemia. Peripheral blood smear shows target cells. The family history is positive for similar complaints. Which of the following investigations can best diagnose this condition?

Which of the following is the most common hemoglobinopathy?

A 50-year-old female patient complains of weakness and pain in her back. She has a history of recurrent infections. Laboratory investigations reveal the presence of Bence Jones proteins in her urine. This condition results from the overproduction of abnormal immunoglobulins, which are mostly of which type?

In β-thalassemia, what is the characteristic defect regarding the beta-globin chain?

A patient with sepsis has a TLC of 15,000 cells/mm³ with the following differential: Neutrophils 40%, Eosinophils 7%, Band cells 15%, Metamyelocytes 5%, and Lymphocytes 35%. What is the immature to total neutrophil ratio (I:T ratio)?

Which of the following is involved in hereditary spherocytosis?

Which of the following is an example of a chronic myeloproliferative disorder?

Routine Rh typing includes testing for which antigen?

A 25-year-old man involved in a motorcycle accident incurs a laceration to his thigh. The bleeding is stabilized en route to the hospital, but on arrival, he is noted to have orthostatic hypotension and his hematocrit is 21%. He receives 2 units of PRBCs. As the first unit is nearly finished transfusing, he becomes febrile and hypotensive. Urine output ceases. The serum above the clot in a red top phlebotomy tube is pink. Which of the following complications of transfusion has most likely occurred in this man?

Hematopoietic stem cells differ from progenitor stem cells in that they can: