Hematopathology Practice Questions

Q: This is the peripheral smear of which disease?

Sickle cell anemia. ***Sickle cell anemia*** - The peripheral smear shows characteristic **drepanocytes** (sickle-shaped red blood cells) which are pathognomonic for sickle cell anemia. - These **crescent-shaped cells** result from **hemoglobin S polymerization** under deoxygenated conditions, causing the distinctive morphology. *Thalassemia* - Shows **microcytic hypochromic** red blood cells with **target cells** and **tear drop cells**, not sickle-shaped cells. - **Hemoglobin electrophoresis** would reveal elevated **HbA2** and **HbF** levels, distinguishing it from sickle cell disease. *Iron deficiency anemia* - Characterized by **microcytic hypochromic** red blood cells that are small and pale with increased **central pallor**. - Shows **pencil cells** and **target cells** occasionally, but never the characteristic **sickle-shaped morphology**. *Sideroblastic anemia* - Demonstrates a **dimorphic blood picture** with both **microcytic** and **normocytic** red blood cells present. - **Ringed sideroblasts** are seen in bone marrow with **Prussian blue staining**, but peripheral smear lacks sickle cells.

Question 1

This is the peripheral smear of which disease?

Accepted Answer

Sickle cell anemia

Answer

Thalassemia

Answer

Iron deficiency anemia

Answer

Sideroblastic anemia

Question 2

BCR-ABL1 gene fusion is seen in all of the following conditions except?

Accepted Answer

Chronic lymphocytic leukemia

Answer

Acute myeloid leukemia

Answer

Chronic myeloid leukemia

Answer

Acute lymphoblastic leukemia

Question 3

Which type of Hodgkin's disease is commonest in females and associated with an excellent prognosis?

Accepted Answer

Nodular sclerosis

Answer

Lymphocyte predominant

Answer

Lymphocyte depleted

Answer

Mixed cellularity

Question 4

Which coagulation test is typically prolonged in hemophilia?

Accepted Answer

Activated partial thromboplastin time (APTT)

Answer

Prothrombin time (PT)

Answer

Clotting time (CT)

Answer

Fibrin degradation products (FDP)

Question 5

Which subtype of Hodgkin lymphoma is associated with the maximum incidence of 'B' symptoms?

Accepted Answer

Mixed cellularity type

Answer

Nodular sclerosis type

Answer

Lymphocyte predominant type

Answer

Lymphocyte rich type

Question 6

Bence Jones proteinuria may be seen in:

Accepted Answer

Mu heavy chain disease

Answer

Alpha heavy chain disease

Answer

Gamma heavy chain disease

Answer

Epsilon heavy chain disease

Question 7

Which of the following is NOT a characteristic feature of multiple myeloma?

Accepted Answer

Hypercalcemia

Answer

Hyperuricemia

Answer

Increased serum alkaline phosphatase

Answer

Monoclonal M band

Question 8

Splenic auto-infarction is typically seen in which of the following conditions?

Accepted Answer

Sickle cell disease

Answer

Splenic amyloidosis

Answer

Thalassemia

Answer

Gaucher disease

Question 9

Raised aPTT is seen in all of the following bleeding disorders except?

Accepted Answer

Henoch-Schonlein purpura

Answer

Hemophilia A

Answer

Hemophilia B

Answer

Von-Willebrand disease

Question 10

What is the highest level of LAP seen in?

Accepted Answer

Polycythemia Vera

Answer

Chronic Myeloid Leukemia (CML)

Answer

Acute Myeloid Leukemia (AML)

Answer

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Hematopathology — MCQs

Hematopathology — MCQs

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