Hematopathology Practice Questions

Q: All of the following statements regarding pathological inclusions are true EXCEPT?

Cabot rings occur in iron deficiency anemia.. **Explanation:** The correct answer is **C**. **Cabot rings** are thin, red-purple, thread-like strands found in the shape of a loop or figure-of-eight within erythrocytes. They are remnants of the **mitotic spindle** (microtubules), not iron. While they are seen in megaloblastic anemia, lead poisoning, and myelodysplastic syndromes, they are **not** a characteristic feature of iron deficiency anemia. **Analysis of other options:** * **A. Howell-Jolly bodies:** These are small, round, purple nuclear remnants (DNA). Normally, the spleen’s "pitting" function removes them [1]. Therefore, they are classic markers of **splenectomy** or functional asplenia (e.g., Sickle Cell Anemia) [2]. * **B. Basophilic stippling:** This represents coarse or fine blue granules (precipitated **ribosomes/RNA**). It is a hallmark of **lead poisoning** (due to inhibition of pyrimidine 5'-nucleotidase) and is also seen in thalassemias and sideroblastic anemia. * **D. Heinz bodies:** These are inclusions of **denatured hemoglobin** [1]. While most commonly associated with **G6PD deficiency** (oxidative stress), they are also seen in **thalassemias** due to the precipitation of excess globin chains [1]. **NEET-PG High-Yield Pearls:** * **Pappenheimer bodies:** Siderotic granules (iron) seen in Sideroblastic anemia; confirmed with **Prussian Blue stain**. * **Heinz bodies** require **Supravital stains** (Crystal violet/Methylene blue) to be visualized; they are not seen on routine Leishman/Wright stains [1]. * **Bite cells (Degmacytes):** Result from splenic macrophages plucking out Heinz bodies [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Red Blood Cell and Bleeding Disorders, pp. 642-654. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Red Blood Cell and Bleeding Disorders, pp. 652-654.

Question 1

What is the most common cause of Hereditary Spherocytosis?

Accepted Answer

Ankyrin

Answer

Spectrin

Answer

Glycophorin

Answer

Band 4

Question 2

Which type of lymphoma has a higher incidence in females?

Accepted Answer

Follicular lymphoma

Answer

Mantle cell lymphoma

Answer

Burkitt's lymphoma

Answer

Diffuse large B cell lymphoma

Question 3

What is the least commonly found type of Hodgkin's lymphoma?

Accepted Answer

Lymphocyte depleted

Answer

Nodular sclerosis

Answer

Lymphocyte rich

Answer

Nodular lymphocyte predominant

Question 4

The peripheral smear of hereditary spherocytosis will typically show spherocytes. What is the characteristic size of these spherocytes compared to normal red blood cells?

Accepted Answer

Smaller size than RBCs

Answer

Usually of the same size as RBCs

Answer

Reticulocytosis is absent

Answer

Anemia is negligible

Question 5

The Hodgkin lymphoma subtype that particularly involves the anterior mediastinum is:

Accepted Answer

Nodular sclerosing

Answer

Lymphocyte predominant

Answer

Lymphocyte depleted

Answer

Mixed cellularity

Question 6

All of the following statements regarding pathological inclusions are true EXCEPT?

Accepted Answer

Cabot rings occur in iron deficiency anemia.

Answer

Howell-Jolly bodies occur in splenectomized patients.

Answer

Basophilic stippling is seen in lead intoxication.

Answer

Heinz bodies are seen in thalassemia.

Question 7

A 15-year-old boy presented with anemia and jaundice. On examination, his hemoglobin was 6 g/dL, USG showed gallstones, and the peripheral smear showed bite cells. What is the most likely diagnosis?

Accepted Answer

Hereditary ovalocytosis

Answer

Hereditary acanthocytosis

Answer

Hereditary spherocytosis

Answer

Hereditary xerocytosis

Question 8

What is the most common cause of increased red cell protoporphyrin levels?

Accepted Answer

Iron deficiency

Answer

Thiamine deficiency

Answer

Reactive lymphocytosis

Answer

Drug toxicity

Question 9

Castleman's disease is associated with a defect in which of the following interleukins?

Accepted Answer

Interleukin 6 (IL-6)

Answer

Interleukin 1 (IL-1)

Answer

Interleukin 4 (IL-4)

Answer

Interleukin 8 (IL-8)

Question 10

A low LAP/NAP score may be seen in all of the following except?

Accepted Answer

Pregnancy

Answer

CML

Answer

PNH

Answer

AIHA

Hematopathology — MCQs

Hematopathology — MCQs

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