Hematopathology Practice Questions

Q: Gandy-Gandy bodies are typically seen in chronic venous congestion of which of the following organs?

Spleen. **Explanation:** **Gandy-Gamna bodies** (also known as Gamna-Gandy bodies or Siderofibrotic nodules) are a classic histopathological finding in the **Spleen**. 1. **Mechanism (Why Spleen is correct):** In conditions causing chronic venous congestion of the spleen (most commonly **Portal Hypertension**), there is increased pressure leading to focal hemorrhages within the splenic parenchyma. As the blood breaks down, deposits of **hemosiderin** (iron) and **calcium** form on the fibrous connective tissue and elastic fibers [1]. Microscopically, these appear as yellow-brown or rust-colored nodules consisting of fibrous tissue, iron, and calcium salts. 2. **Analysis of Incorrect Options:** * **Lung:** Chronic venous congestion of the lung (often due to left heart failure) leads to the formation of **Heart Failure Cells** (hemosiderin-laden macrophages in the alveoli), not Gandy-Gamna bodies. * **Liver:** Chronic venous congestion here results in the **"Nutmeg Liver"** appearance due to centrilobular necrosis and congestion, but it does not typically form siderofibrotic nodules. * **Kidney:** Congestion in the kidney leads to dusky, enlarged organs but lacks the specific fibro-calcific and iron-laden reaction seen in the spleen. **High-Yield Clinical Pearls for NEET-PG:** * **Staining:** Gandy-Gamna bodies stain positive with **Prussian Blue** (for iron) and **Von Kossa** (for calcium). * **Common Associations:** Portal hypertension (due to Cirrhosis), Sickle Cell Anemia, and Splenic Lymphoma. * **Radiology:** On MRI, they appear as multiple low-signal intensity foci (due to the paramagnetic effect of iron) on T2-weighted sequences, often referred to as the "tobacco-fleck" appearance. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus, pp. 630-634.

Question 1

Which of the following findings is NOT typically seen in hemolytic anemia?

Accepted Answer

Hemochromatosis

Answer

Hemosiderosis

Answer

Cholelithiasis

Answer

None of the above

Question 2

Gandy-Gandy bodies are typically seen in chronic venous congestion of which of the following organs?

Accepted Answer

Spleen

Answer

Lung

Answer

Kidney

Answer

Liver

Question 3

Intravascular hemolysis occurs in which of the following conditions?

Accepted Answer

Paroxysmal nocturnal hemoglobinuria

Answer

Hereditary spherocytosis

Answer

Autoimmune hemolytic anemia

Answer

Thalassemia

Question 4

Which of the following is true about Burkitt's lymphoma?

Accepted Answer

Shows a starry sky pattern on histology

Answer

Associated with t(14;18)

Answer

Expresses BCL-2

Answer

Slowly progressing

Question 5

Which of the following is NOT a feature of histiocytosis?

Accepted Answer

CD127 marker

Answer

Antigen processing cells

Answer

CD1a marker present

Answer

Osteolytic lesions

Question 6

A 22-year-old African American male, with no prior history of signs or symptoms of sickle cell anemia, wants to know if he has sickle cell trait. Which laboratory method can be used to detect the presence of hemoglobin S?

Accepted Answer

Metabisulfite test

Answer

Coombs' test

Answer

Osmotic fragility test

Answer

Sucrose hemolysis test

Question 7

All of the following are features of Hemophagocytic Lymphohistiocytosis (HLH), except?

Accepted Answer

Hyperfibrinogenemia

Answer

Fever

Answer

Splenomegaly

Answer

Hyperferritinemia

Question 8

Disseminated Intravascular Coagulation (DIC) is most commonly seen in which AML subtype?

Accepted Answer

M3

Answer

M2

Answer

M4

Answer

M5

Question 9

The typical bone marrow finding in Idiopathic Thrombocytopenic Purpura (ITP) is:

Accepted Answer

Increased megakaryocytes

Answer

Absent megakaryocytes

Answer

Foam cells

Answer

Fragmented megakaryocytes

Question 10

Splenomegaly may be a feature of which of the following conditions?

Accepted Answer

Sickle cell anemia

Answer

Megaloblastic anemia

Answer

Thalassemia

Answer

G6PD deficiency

Hematopathology — MCQs

Hematopathology — MCQs

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