Hematopathology — MCQs

Pernicious anemia is associated with which of the following pathologies?

A 53-year-old male presents with an enlarged supraclavicular lymph node. Examination reveals enlargement of the Waldeyer ring of oropharyngeal lymphoid tissue. There is no hepatosplenomegaly. Lymph node biopsy reveals replacement by a monomorphous population of large lymphoid cells with enlarged nuclei and prominent nucleoli. The CBC is normal except for mild anemia. Immunohistochemical staining and flow cytometry of the node reveals that most lymphoid cells are CD19+, CD10-, CD3-, CD15-, and TdT negative. What is the most likely diagnosis?

The nucleotide triplet CTC in the sixth position of the beta-globin chain in DNA forms the complementary nucleotide on mRNA that codes for glutamic acid. A point mutation on the beta-globin chain resulting in the nucleotide triplet CAC forms a complementary nucleotide on mRNA that codes for valine. In sickle cell anemia, what is the expected complementary nucleotide triplet on mRNA, read 5' to 3'?

Purpura fulminans is seen in?

What is the cause of alpha thalassemia?

What is the rarest variety of multiple myeloma?

Which one of the following lymphomas is associated with the translocation of the c-myc gene on chromosome 8?

The 'hair on end' appearance on peripheral blood smear is characteristic of which of the following conditions?

Sickle cell disease is due to which type of genetic mutation?

A young boy presented with dyspnea and was found to have a mediastinal mass. Which of the following conditions is known to produce mediastinal lymphadenopathy?