General Pathology Practice Questions

Q: Which of the following is not typically seen in extraglandular Sjögren syndrome?

Splenomegaly. Sjögren syndrome (SS) is a chronic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands (sicca symptoms) and potential extraglandular manifestations. **Why Splenomegaly is the Correct Answer:** While Sjögren syndrome involves systemic inflammation, **splenomegaly is not a typical or diagnostic feature** of the disease. If a patient with SS develops significant splenomegaly or lymphadenopathy, it is often a red flag for the development of B-cell lymphoma rather than a standard manifestation of the syndrome itself. **Analysis of Incorrect Options:** * **A. Rheumatoid Arthritis:** This is the most common condition associated with **Secondary Sjögren syndrome**. Approximately 30-50% of RA patients develop secondary SS [1]. * **B. Raynaud Phenomenon:** This is a well-documented extraglandular manifestation, occurring in about 13-37% of SS patients, often predating the sicca symptoms. * **C. Lymphoma:** Patients with SS have a **40-fold increased risk** of developing Non-Hodgkin Lymphoma (specifically MALT lymphoma). This is a classic high-yield association for exams. **High-Yield Clinical Pearls for NEET-PG:** * **Serology:** Positive for **Anti-Ro (SS-A)** and **Anti-La (SS-B)** antibodies. Anti-Ro is associated with an increased risk of neonatal lupus and congenital heart block. * **Diagnostic Gold Standard:** Lip biopsy showing **focal lymphocytic sialadenitis** (Focus score >1). * **Schirmer Test:** Used to quantify decreased lacrimation (<5mm in 5 minutes). * **Mikulicz Syndrome:** Historical term for bilateral enlargement of salivary and lacrimal glands (now often associated with IgG4-related disease or SS). **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Osteoarticular And Connective Tissue Disease, pp. 678-679.

Question 1

Which of the following is not typically seen in extraglandular Sjögren syndrome?

Accepted Answer

Splenomegaly

Answer

Rheumatoid arthritis

Answer

Raynaud phenomenon

Answer

Lymphoma

Question 2

Amyloidosis is most commonly secondary to which of the following conditions?

Accepted Answer

Chronic suppuration

Answer

Acute inflammation

Answer

Cellular necrosis

Answer

Hyaline degeneration

Question 3

In sarcoidosis, which of the following is histologically true?

Accepted Answer

Epithelioid cells with no caseation

Answer

Epithelioid cells showing caseation

Answer

Histiocytic cells with caseation

Answer

Well-differentiated histiocytic cells

Question 4

The process of wound healing includes all of the following except?

Accepted Answer

Fibrolysis

Answer

Coagulation

Answer

Matrix synthesis

Answer

Angiogenesis

Question 5

Aging is most probably due to:

Accepted Answer

Accumulated free radical injury in tissues

Answer

Non-random mutation in somatic cells

Answer

Decrease in collagen cross-linking

Answer

Increase in superoxide dismutase

Question 6

What is the most common site of thrombosis?

Accepted Answer

Vein

Answer

Artery

Answer

Heart

Answer

Capillary

Question 7

Which of the following is NOT included in chronic myeloproliferative disorders?

Accepted Answer

Erythroleukemia

Answer

Polycythemia vera

Answer

Chronic myeloid leukemia (CML)

Answer

Essential thrombocytosis

Question 8

Which one of the listed statements is the best histologic definition of an abscess?

Accepted Answer

A circumscribed collection of neutrophils with necrotic cellular debris

Answer

A localized defect that results from the sloughing of necrotic inflammatory tissue from the surface of an organ

Answer

A localized proliferation of fibroblasts and small blood vessels

Answer

An aggregate of two or more activated macrophages

Question 9

The amyloid protein in primary systemic amyloidosis belongs to which of the following classes of fibril proteins?

Accepted Answer

AL protein

Answer

AA protein

Answer

Amyloid beta precursor protein

Answer

Beta 2 microglobulin

Question 10

Which of the following is NOT true about graft versus host reaction?

Accepted Answer

None of the above

Answer

Lymphocytic infiltration of portal tract

Answer

Bile duct damage

Answer

Intrahepatic cholestasis

General Pathology — MCQs

General Pathology — MCQs

On this page

Practice by Chapter

Want unlimited practice?