General Pathology Practice Questions

Q: What is the characteristic translocation seen in mantle cell lymphoma?

t(11;14). **Explanation:** **Mantle Cell Lymphoma (MCL)** is a B-cell neoplasm characterized by the chromosomal translocation **t(11;14)(q13;q32)**. This translocation involves the fusion of the **CCND1 gene** (on chromosome 11) with the **IgH (Immunoglobulin Heavy chain) promoter** (on chromosome 14). This leads to the constitutive overexpression of **Cyclin D1**, a protein that promotes the transition of cells from the G1 to the S phase of the cell cycle, driving uncontrolled cellular proliferation. **Analysis of Incorrect Options:** * **A. t(8;14):** This is the hallmark of **Burkett Lymphoma**. It involves the translocation of the *c-MYC* proto-oncogene to the IgH locus, leading to rapid cell growth (starry-sky appearance). * **C. t(11;18):** This is associated with **MALT lymphoma** (Mucosa-Associated Lymphoid Tissue). It involves the fusion of *API2* and *MALT1* genes. * **D. t(9;22):** Known as the **Philadelphia Chromosome**, this is characteristic of **Chronic Myeloid Leukemia (CML)** and some cases of ALL. It creates the *BCR-ABL1* fusion protein with tyrosine kinase activity. **High-Yield Clinical Pearls for NEET-PG:** * **Immunophenotype:** MCL cells are typically **CD5+**, **CD20+**, and **Cyclin D1 positive**, but notably **CD23 negative** (helps differentiate it from CLL/SLL). * **Morphology:** Look for a "mantle" of small-to-medium-sized lymphocytes surrounding a germinal center [1]. * **Clinical Presentation:** Often presents in elderly males with lymphadenopathy and frequent involvement of the gastrointestinal tract (appearing as **lymphomatous polyposis**) [1]. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Diseases Of The Urinary And Male Genital Tracts, pp. 562-563.

Question 1

Fibrinoid necrosis is seen in which of the following conditions, except?

Accepted Answer

Diabetes mellitus

Answer

Serum sickness

Answer

Arthus reaction

Answer

Systemic lupus erythematosus

Question 2

What is the characteristic translocation seen in mantle cell lymphoma?

Accepted Answer

t(11;14)

Answer

t(8;14)

Answer

t(11;18)

Answer

t(9;22)

Question 3

Which of the following is a single gene disorder?

Accepted Answer

Diabetes Mellitus

Answer

Glycogen storage disease

Answer

Retinoblastoma

Answer

Hypertension

Question 4

A ganglion of tendons is an example of which of the following processes?

Accepted Answer

Myxomatous degeneration

Answer

Neoplastic process

Answer

Malformation

Answer

Amyloid deposition

Question 5

Which of the following disorders is due to maternal disomy of chromosome 15?

Accepted Answer

Angelman syndrome

Answer

Prader Willi syndrome

Answer

Hydatidiform mole

Answer

Klinefelter's syndrome

Question 6

Which of the following is a feature of innate immunity?

Accepted Answer

Includes phagocytes and natural killer cells

Answer

Recognizes foreign antigen in blood

Answer

C-reactive protein

Answer

Complement protein is a part of the innate immune system

Question 7

Which of the following is a characteristic morphological feature of apoptosis?

Accepted Answer

Councilman bodies

Answer

Chromatid bodies

Answer

Citron bodies

Answer

Call-Exner bodies

Question 8

Which of the following procedures is routinely used for karyotyping using light microscopy?

Accepted Answer

G-banding

Answer

C-banding

Answer

Q-banding

Answer

BrdU-staining

Question 9

Apoptosis is initiated by?

Accepted Answer

Caspases

Answer

Bcl-2

Answer

Bcl-X

Answer

p53

Question 10

Which of the following is an antibody against tumor cells?

Accepted Answer

MHC-I

Answer

MHC-II

Answer

Anti-viral

Answer

Differentiated antigen

General Pathology — MCQs

General Pathology — MCQs

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