General Pathology Practice Questions

Q: Ruston bodies are present in which of the following?

All of the above. **Explanation:** **Rushton bodies** (also known as hyaline bodies) are unique, eosinophilic, linear, or curved microscopic structures found within the epithelial lining of various odontogenic cysts. 1. **Why "All of the above" is correct:** Rushton bodies are considered a product of the odontogenic epithelium [1]. They are most commonly associated with the **Radicular cyst (Apical periodontal cyst)**, occurring in approximately 10% of cases. However, they are not pathognomonic for a single entity and can be found in the lining of several other odontogenic cysts, including **Infected Dentigerous cysts**, **Gingival cysts**, and Odontogenic Keratocysts (OKC). Their presence is generally attributed to the degeneration of odontogenic epithelium or inflammatory exudates. 2. **Analysis of Options:** * **Apical Periodontal Cyst:** The most frequent site for Rushton bodies due to the chronic inflammatory nature of the lesion. * **Infected Dentigerous Cyst:** Inflammation often triggers the formation of these bodies within the reduced enamel epithelium. * **Gingival Cyst of Neonate:** Though less common, these bodies can be identified in the epithelial remnants (Rest of Serres) of the gingiva. **High-Yield Clinical Pearls for NEET-PG:** * **Morphology:** They appear as "hairpin," "circular," or "polycyclic" structures and are often brittle, showing cracks. * **Staining:** They are **PAS-positive** and diastase-resistant, indicating a glycoprotein composition. * **Origin:** The most accepted theory is that they represent a secretory product of odontogenic epithelium (though some older theories suggested they were hematogenous in origin) [1]. * **Differential:** Do not confuse Rushton bodies with **Civatte bodies** (seen in Lichen Planus) or **Negri bodies** (seen in Rabies). **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Head and Neck, p. 741.

Question 1

Ruston bodies are present in which of the following?

Accepted Answer

All of the above

Answer

Apical periodontal cyst

Answer

Infected dentigerous cyst

Answer

Gingival cyst of neonate

Question 2

Which of the following chemical mediators of inflammation is an example of a C-X-C or alpha chemokine?

Accepted Answer

Interleukin IL-8

Answer

Lipoxin LXA-4

Answer

Interleukin IL-6

Answer

Monocyte chemoattractant protein MCP-1

Question 3

Which of the following proteins is NOT typically found in amyloid deposits in senile amyloidosis?

Accepted Answer

AL protein

Answer

Transthyretin

Answer

Beta-amyloid protein

Answer

Amyloid of prion

Question 4

Which of the following vascular lesions has the least clinical significance?

Accepted Answer

Monckeberg's medial calcification

Answer

Hyaline arteriolosclerosis

Answer

Hyperplastic arteriolosclerosis

Answer

Glomus tumor

Question 5

Endotoxic shock is propagated by which of the following mechanisms?

Accepted Answer

Cytokine action

Answer

Endothelial injury

Answer

Peripheral vasodilation

Answer

Increased vascular permeability

Question 6

Which one of the following manifestations is more likely to be found in the diffuse form of systemic sclerosis than in the limited variant?

Accepted Answer

Pulmonary involvement

Answer

Esophageal dysmotility

Answer

Distal skin thickening

Answer

Renal disease

Question 7

Cloudy swelling is:

Accepted Answer

Reversible

Answer

Irreversible

Answer

Physiological and never pathological

Answer

Late manifestation of cell injury

Question 8

In which phase of the cell cycle is the cellular content of DNA doubled?

Accepted Answer

S phase

Answer

M phase

Answer

G1 phase

Answer

G2 phase

Question 9

Which cells are most sensitive to hypoxic injury?

Accepted Answer

Neurons

Answer

Myocardial cells

Answer

Skeletal muscles

Answer

All of the above

Question 10

The Cyclin D-IGH fusion gene is associated with which of the following conditions?

Accepted Answer

Burkitt lymphoma

Answer

Mantle cell lymphoma

Answer

Follicular lymphoma

Answer

Melanoma

General Pathology — MCQs

General Pathology — MCQs

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