General Pathology Practice Questions

Q: What is the most common type of ocular lymphoma?

B-cell non-Hodgkin's lymphoma. **Explanation:** Primary Intraocular Lymphoma (PIOL) is a subset of Primary Central Nervous System Lymphoma (PCNSL). The vast majority (over 95%) of ocular lymphomas are **B-cell non-Hodgkin’s lymphomas**, specifically the **Diffuse Large B-cell Lymphoma (DLBCL)** subtype [1]. These typically involve the retina, vitreous, and optic nerve [1]. Another common site is the ocular adnexa (orbit, eyelids, conjunctiva), where **MALT lymphoma** (Extranodal Marginal Zone B-cell Lymphoma) is the most frequent histological type [2]. **Analysis of Options:** * **Option A & D (T-cell/Pre T-cell Lymphoma):** While T-cell lymphomas can occur in the eye, they are extremely rare [2]. They are more frequently associated with systemic involvement or specific geographic regions (e.g., NK/T-cell lymphoma in Asia). * **Option B (Hodgkin’s Lymphoma):** Hodgkin’s lymphoma almost exclusively involves the lymph nodes and very rarely presents as a primary extranodal disease in the eye. **Clinical Pearls for NEET-PG:** * **Masquerade Syndrome:** Ocular lymphoma is known as a "masquerade syndrome" because it often mimics chronic uveitis or vitritis, leading to delayed diagnosis [1]. * **CNS Association:** Approximately 60-80% of patients with primary vitreoretinal lymphoma will eventually develop CNS involvement [1]. * **Diagnostic Gold Standard:** Diagnostic vitrectomy with cytological examination and flow cytometry (looking for monoclonal B-cell populations) is the preferred investigation [1]. * **Cytokine Marker:** An elevated **IL-10 to IL-6 ratio (>1.0)** in the vitreous fluid is highly suggestive of B-cell lymphoma. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Eye, pp. 1341-1342. [2] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Diseases Of The Urinary And Male Genital Tracts, pp. 565-566.

Question 1

Neurofibromatosis is associated with all of the following except?

Accepted Answer

Autosomal recessive inheritance

Answer

Cutaneous fibromas

Answer

Cataract

Answer

Scoliosis

Question 2

Which among the following is not an adhesion molecule?

Accepted Answer

Transferrin

Answer

Integrin

Answer

Selectin

Answer

Cadherins

Question 3

Which of the following is NOT an X-linked disorder?

Accepted Answer

Cystic fibrosis

Answer

Hemophilia A

Answer

Duchenne muscular dystrophy

Answer

Fragile X syndrome

Question 4

Which virus is known to cause hemopoietic carcinoma?

Accepted Answer

Epstein-Barr virus (EBV)

Answer

Human T-lymphotropic virus type I (HTLV-I)

Answer

Human herpesvirus 8 (HHV-8)

Answer

Cytomegalovirus (CMV)

Question 5

What is the chance of having cystic fibrosis if only one parent is affected and the other is normal?

Accepted Answer

50%

Answer

25%

Answer

70%

Answer

80%

Question 6

What is the primary protein responsible for the tensile strength of tendons?

Accepted Answer

Collagen

Answer

Fibrillin

Answer

Fibronectin

Answer

Elastin

Question 7

HLA-I is present on which of the following?

Accepted Answer

All nucleated cells

Answer

Only on cells of the immune system

Answer

Only on B-cells

Answer

Only on T-cells

Question 8

Cell-mediated immune response is which type of hypersensitivity?

Accepted Answer

Type IV

Answer

Type I

Answer

Type II

Answer

Type III

Question 9

What is the most common type of ocular lymphoma?

Accepted Answer

B-cell non-Hodgkin's lymphoma

Answer

T-cell lymphoma

Answer

Hodgkin's lymphoma

Answer

Pre T-cell lymphoma

Question 10

A post-mortem clot is most likely to:

Accepted Answer

Grossly have the appearance of “chicken fat” overlying “currant jelly”

Answer

Grossly display features of recanalization

Answer

Grossly have lines of Zahn

Answer

Microscopically appear attached to the wall of the blood vessel

General Pathology — MCQs

General Pathology — MCQs

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