General Pathology Practice Questions

Question 1

All of the following statements are true regarding hyperplasia, except:

Accepted Answer

Bone marrow hyperplasia is not seen in response to peripheral blood cytopenias

Answer

Seen in cells capable of dividing (labile cells)

Answer

There is an increase in the number of cells

Answer

Pathological hyperplasia can be a risk factor for malignancy

Question 2

Hypoxia is a common cause of cell injury. Which of the following is NOT a cause of hypoxia?

Accepted Answer

All of the above

Answer

Ischemia

Answer

Respiratory failure

Answer

Carbon monoxide poisoning

Question 3

Which interleukin is characteristically produced by TH1 cells?

Accepted Answer

Interleukin 2

Answer

Interleukin 5

Answer

Interleukin 4

Answer

Interferon gamma

Question 4

Granularity of oncocyte cytoplasm is due to which cellular organelle?

Accepted Answer

Overabundance of mitochondria

Answer

Overabundance of Golgi bodies

Answer

Deficiency of mitochondria

Answer

Deficiency of Golgi bodies

Question 5

All of the following are true regarding innate immunity except:

Accepted Answer

In Bruton's agammaglobulinemia, opsonization is impaired.

Answer

NADPH oxidase generates superoxide ions.

Answer

Chediak-Higashi syndrome is due to defective phagolysosome formation.

Answer

Myeloperoxidase action is mainly due to hypochlorous acid (HOCl).

Question 6

Which of the following pigments are involved in free radical injury?

Accepted Answer

Lipofuscin

Answer

Melanin

Answer

Bilirubin

Answer

Hematin

Question 7

Which of the following is NOT true about apoptosis?

Accepted Answer

Inflammation is present

Answer

Chromosomal breakage

Answer

Clumping of chromatin

Answer

Cell shrinkage

Question 8

What is the most common cause of Down syndrome?

Accepted Answer

Maternal nondisjunction

Answer

Paternal nondisjunction

Answer

Translocation

Answer

Mosaicism

Question 9

Which of the following is NOT a feature of malignant transformation by cultured cells?

Accepted Answer

Increased requirement for growth factors

Answer

Increased cell density

Answer

Alterations of cytoskeletal structures

Answer

Loss of anchorage

Question 10

In Lysosomal storage disorders, which of the following statements is true?

Accepted Answer

Lysosomes are deficient in the enzyme hydrolase.

Answer

There is a defect in the fusion of lysosomes and phagosomes.

Answer

There is a defect in the lysosomal membrane.

Answer

There is increased degradation of heteroglycans.

General Pathology — MCQs

General Pathology — MCQs

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