General Pathology Practice Questions

Q: Dohle bodies are seen in which of the following cells?

Neutrophils. **Explanation:** **Dohle bodies** are small, light blue-gray, oval inclusions found in the periphery of the cytoplasm of **neutrophils**. They represent remnants of **rough endoplasmic reticulum (RER)** arranged in parallel stacks. 1. **Why Neutrophils are Correct:** Dohle bodies are classic markers of "toxic changes" in neutrophils. They appear when there is accelerated granulopoiesis (rapid production of white blood cells), typically during severe bacterial infections, burns, trauma, or systemic inflammatory states [1], [2]. They are often seen alongside other toxic features like toxic granulation and cytoplasmic vacuolation. 2. **Why Other Options are Incorrect:** * **Macrophages & Histiocytes:** While these cells are part of the mononuclear phagocyte system and may contain phagocytosed debris or pigments (like hemosiderin), they do not form Dohle bodies. * **Plasma Cells:** These cells are characterized by Russell bodies (intracellular immunoglobulin aggregates) or Mott cells, but not Dohle bodies. **High-Yield Clinical Pearls for NEET-PG:** * **Composition:** Dohle bodies consist of aggregated **ribosomes and RER**. * **May-Hegglin Anomaly:** This is a key differential. It is an autosomal dominant triad of: 1. Large, **Dohle-like bodies** in neutrophils (composed of non-muscle myosin heavy chain IIA). 2. Giant platelets. 3. Thrombocytopenia. * **Differential Diagnosis:** Apart from infections, they can be seen in pregnancy and after the administration of G-CSF (Granulocyte colony-stimulating factor). **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Blood And Bone Marrow Disease, pp. 580-581. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus, p. 592.

Question 1

All of the following statements regarding amyloidosis are true, EXCEPT:

Accepted Answer

The term 'amyloid' was coined by Rudolf Virchow.

Answer

It is an extracellular deposit.

Answer

It consists of insoluble polymeric protein fibrils.

Answer

Amyloid fibrils share a common cross-beta pleated sheet structure.

Question 2

Mitochondrial abnormality is seen in which of the following conditions?

Accepted Answer

Wilson's disease

Answer

Krabbe's disease

Answer

Fabry disease

Answer

Fanconi syndrome

Question 3

Cloudy swelling occurs in which of the following organs, EXCEPT?

Accepted Answer

Lungs

Answer

Kidney

Answer

Liver

Answer

Adrenals

Question 4

Dohle bodies are seen in which of the following cells?

Accepted Answer

Neutrophils

Answer

Macrophages

Answer

Plasma cells

Answer

Histiocytes

Question 5

Amyloidosis of the kidney may be seen in which of the following conditions, except?

Accepted Answer

Enteric fever

Answer

Ulcerative colitis

Answer

Suppurative lung disease

Answer

Hansen's disease

Question 6

All of the following statements are true regarding reversible cell injury except?

Accepted Answer

Formation of amorphous densities in the mitochondrial matrix

Answer

Diminished generation of adenosine triphosphate

Answer

Formation of blebs in the plasma membrane

Answer

Detachment of ribosomes from the granular endoplasmic reticulum

Question 7

Which apoptotic gene is also associated with autophagy?

Accepted Answer

BCL-2

Answer

p53

Answer

BAX

Answer

BID

Question 8

Serum amyloid A protein is associated with which of the following conditions?

Accepted Answer

Chronic inflammatory states

Answer

Alzheimer's disease

Answer

Chronic renal failure

Answer

Malignant hypertension

Question 9

White infarct is typically seen in which organ?

Accepted Answer

Liver

Answer

Lung

Answer

Intestine

Answer

Ovary

Question 10

All of the following are neoplasms found in patients with HIV infection EXCEPT?

Accepted Answer

Hepatocellular carcinoma

Answer

Kaposi sarcoma

Answer

Primary lymphoma of brain

Answer

Invasive cancer of uterine cervix

General Pathology — MCQs

General Pathology — MCQs

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