General Pathology Practice Questions

Q: Craig's cyst is classified as which of the following?

All of the above.. **Explanation:** The correct answer is **D. All of the above.** **Craig’s cyst** is a historical and eponymous term used to describe a specific type of inflammatory odontogenic cyst that occurs on the buccal aspect of a mandibular permanent first or second molar. In contemporary oral pathology, this entity is most commonly referred to as the **Buccal Bifurcation Cyst (BBC)**. * **Why all options are correct:** The terminology for this lesion has evolved over time. It is classified as a **Paradental cyst** because it arises near the cervical margin of the tooth (para-dental) due to inflammation, typically associated with enamel projections into the bifurcation area. It is specifically called a **Buccal bifurcation cyst** due to its classic anatomical location. Furthermore, because it occurs on the side of the root rather than at the apex, it is also categorized as a **Collateral cyst**. Therefore, all three terms (A, B, and C) are synonymous or overlapping classifications for the same clinical entity. **Clinical Pearls for NEET-PG:** * **Classic Presentation:** A child (usually 6–12 years old) presenting with a swelling on the buccal aspect of a mandibular first molar that is currently erupting. * **Radiographic Feature:** A well-circumscribed radiolucency involving the buccal bifurcation; the roots of the involved molar are often tipped lingually. * **Pathogenesis:** Associated with **buccal enamel extensions** into the bifurcation, which predispose the area to pocket formation and subsequent inflammatory cystic change. * **Treatment:** Conservative enucleation without extraction of the involved tooth is the standard of care.

Question 1

The Ann Arbor classification is used for staging which of the following conditions?

Accepted Answer

Hodgkin lymphoma

Answer

Retinoblastoma

Answer

Nephroblastoma

Answer

Neuroblastoma

Question 2

Intracellular accumulation of which of the following forms Russell bodies?

Accepted Answer

Immunoglobulins

Answer

Cholesterol

Answer

Phospholipids

Answer

Lipoproteins

Question 3

Which of the following describes the role of CD-95 in apoptosis initiation through death receptors?

Accepted Answer

It induces apoptosis when engaged by Fas ligand.

Answer

Cytochrome C binds to Apoptosis Activating Factor-1 (Apaf-1).

Answer

Apoptosis may be initiated by caspase activation.

Answer

Apoptosis is mediated through DNA damage.

Question 4

Frozen section examination demonstrates fibrosis and cystic spaces. Also seen are areas of compressed glands with a lobular orientation. The glands are lined by a single layer of epithelial cells with oval nuclei and regular arrangement. No true invasion of glands into the adjacent stroma is seen. What is the most likely diagnosis?

Accepted Answer

Sclerosing adenosis

Answer

Atypical ductal hyperplasia

Answer

Ductal carcinoma in situ

Answer

Lobular carcinoma in situ

Question 5

Cell-matrix adhesions are mediated by which of the following?

Accepted Answer

Integrins

Answer

Cadherins

Answer

Selectins

Answer

Calmodulin

Question 6

Craig's cyst is classified as which of the following?

Accepted Answer

All of the above.

Answer

Paradental cyst.

Answer

Buccal bifurcation cyst.

Answer

Collateral cyst.

Question 7

Macroglossia is seen in which of the following conditions?

Accepted Answer

Amyloidosis

Answer

Folic acid deficiency

Answer

Motor neurone disease

Answer

None of the above

Question 8

Class I MHC molecules are expressed on all of the following cell types EXCEPT:

Accepted Answer

Red blood cells

Answer

Dendritic cells

Answer

Epithelial cells

Answer

Platelets

Question 9

Secondary (AA) amyloidosis is seen in all of the following conditions except?

Accepted Answer

Multiple myeloma

Answer

Rheumatoid arthritis (RA)

Answer

Tuberculosis (TB)

Answer

Renal cell carcinoma (RCC)

Question 10

Which of the following is NOT true about apoptosis?

Accepted Answer

Apoptosis of cells induces an inflammatory reaction.

Answer

Considerable apoptosis may occur in tissues before it becomes apparent in histology.

Answer

Apoptotic cells appear as round masses of intensely eosinophilic cytoplasm with dense nuclear chromatin fragments.

Answer

Macrophages phagocytose the apoptotic cells and degrade them.

General Pathology — MCQs

General Pathology — MCQs

On this page

Practice by Chapter

Want unlimited practice?