General Pathology Practice Questions

Q: A histopathological image of a cystic lesion is shown. What is the most likely diagnosis?

Papillary cystadenoma lymphomatosum. ***Papillary cystadenoma lymphomatosum*** - Features characteristic **bilayered oncocytic epithelium** lining papillary projections within cystic spaces, creating a distinctive architectural pattern. - Contains **lymphoid stroma with germinal centers**, which is pathognomonic for Warthin's tumor and distinguishes it from other cystic lesions. *Dentigerous cyst* - Shows simple **squamous epithelial lining** derived from dental follicle, lacking the complex papillary architecture. - Associated with **unerupted teeth** and contains dental follicular tissue, not lymphoid stroma. *Odontogenic keratocyst* - Characterized by **parakeratinized stratified squamous epithelium** with a distinctive palisaded basal layer. - Lacks the **papillary projections** and **lymphoid component** seen in papillary cystadenoma lymphomatosum. *Unicystic ameloblastoma* - Features **ameloblastic epithelium** with characteristic **stellate reticulum** and reverse nuclear polarity. - Shows **odontogenic differentiation** patterns, not the oncocytic epithelium and lymphoid stroma of Warthin's tumor.

Question 1

Which of the following statements regarding red infarcts is incorrect?

Accepted Answer

Red infarcts occur in arterial occlusions.

Answer

Red infarcts occur in loose tissues.

Answer

Red infarcts occur in tissues with dual circulations.

Answer

Red infarcts occur in tissues previously congested by sluggish venous outflow.

Question 2

What is the molecular change typically seen in lysosomal storage disorders?

Accepted Answer

Mutation of genes encoding lysosomal hydrolases

Answer

Defective fusion of lysosomes and phagosomes

Answer

Increased synthesis of some substrates

Answer

Membrane defect of lysosomes

Question 3

A histopathological image of a cystic lesion is shown. What is the most likely diagnosis?

Accepted Answer

Papillary cystadenoma lymphomatosum

Answer

Dentigerous cyst

Answer

Odontogenic keratocyst

Answer

Unicystic ameloblastoma

Question 4

What characterizes a granuloma?

Accepted Answer

Focal accumulation of activated macrophages

Answer

Collection of neutrophils

Answer

Newly formed vessels

Answer

Collection of eosinophils

Question 5

A 24-year-old man is found to have an increased total body iron concentration. Biopsy of his liver shows large amounts of granular golden-brown pigment which stains blue with Prussian blue stain. The presence of which one of the following diseases best explains these findings?

Accepted Answer

Hemochromatosis

Answer

Systemic amyloidosis

Answer

Chronic congestive heart failure

Answer

Advanced atrophy

Question 6

Which of the following is true about stem cells?

Accepted Answer

Found in the yolk sac

Answer

Used in gene therapy

Answer

Terminally differentiated cells

Answer

All of the above

Question 7

Accumulation of which of the following substances causes fatty liver?

Accepted Answer

Triglycerides

Answer

Cholesterol

Answer

Cholesterol ester

Answer

Phospholipids

Question 8

What is Turner hypoplasia?

Accepted Answer

Hypoplasia due to local trauma or infection

Answer

Hypoplasia due to systemic infection

Answer

Hypoplasia due to congenital syphilis

Answer

Hypoplasia due to fluoride ingestion

Question 9

Gene for retinoblastoma is located on which chromosome?

Accepted Answer

Chromosome 13

Answer

Chromosome 1

Answer

Chromosome 10

Answer

Chromosome 5

Question 10

Which of the following is an example of metastatic calcification?

Accepted Answer

Milk alkali syndrome

Answer

Psammoma bodies

Answer

Rheumatic heart disease

Answer

Monckeberg's medial calcific sclerosis

General Pathology — MCQs

General Pathology — MCQs

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