General Pathology Practice Questions

Q: Proliferation of cells which are not native to that place is known as:

Both B and C. **Explanation:** The core concept tested here is the distinction between developmental malformations involving tissue displacement versus those involving local overgrowth. **1. Why the Correct Answer is D (Both B and C):** * **Choriostoma (Heterotopia):** This refers to a mass of histologically normal tissue present in an **abnormal anatomical location** (e.g., a nodule of well-developed pancreatic tissue in the submucosa of the stomach). The cells are "not native" to the site. * **Fordyce’s Granules:** These are ectopic sebaceous glands found on the oral mucosa or vermilion border of the lips. Since sebaceous glands are normally associated with hair follicles of the skin and are not native to the oral mucosa, they represent a specific clinical example of a **choriostoma**. **2. Why Option A is Incorrect:** * **Hamartoma:** This is a focal overgrowth of cells and tissues **native** to the organ in which it occurs (e.g., a pulmonary hamartoma containing cartilage, bronchial epithelium, and connective tissue). While the architecture is disorganized, the cellular elements belong to that specific site. **3. High-Yield NEET-PG Pearls:** * **Hamartoma vs. Choriostoma:** Remember "H" for **H**amartoma = **H**ome (native tissue); "C" for **C**horiostoma = **C**hanged location (non-native). * **Common Choriostomas:** Pancreatic tissue in the gallbladder/duodenum; Gastric mucosa in Meckel’s diverticulum. * **Common Hamartomas:** Lungs (most common site), Bile duct hamartomas (Von Meyenburg complexes), and Cowden Syndrome (multiple hamartomas). * **Neoplasia:** Unlike true neoplasms, both hamartomas and choriostomas are developmental anomalies and typically show coordinated growth with the host.

Question 1

Which organ is most vulnerable to ischemic injury due to shock?

Accepted Answer

Heart

Answer

Lungs

Answer

Adrenals

Answer

Kidney

Question 2

Which of the following statements is NOT true for a white infarct?

Accepted Answer

Seen in loose tissues.

Answer

Wedge-shaped area with the apex pointing towards the arterial obstruction.

Answer

Can be transiently red.

Answer

Caused by arterial obstruction.

Question 3

45X0 is the chromosomal abnormality seen in which of the following conditions?

Accepted Answer

Turner's syndrome

Answer

Down's syndrome

Answer

Klinefelter's syndrome

Answer

True hermaphroditism

Question 4

The Human Leukocyte Antigen (HLA) complex is primarily located on which chromosome arm?

Accepted Answer

Short arm of chromosome 6

Answer

Short arm of chromosome 3

Answer

Long arm of chromosome 3

Answer

Chromosome 15

Question 5

Proliferation of cells which are not native to that place is known as:

Accepted Answer

Both B and C

Answer

Harmatoma

Answer

Choriostoma

Answer

Fordyce's granule

Question 6

Intracellular calcification begins in?

Accepted Answer

Mitochondria

Answer

Cytoplasm

Answer

Golgi bodies

Answer

Lysosomes

Question 7

A 28-year-old female patient presents with patches of burns and swelling of the arm. Histopathological findings reveal swelling of the endoplasmic reticulum, blebs from the cell membrane, loss of microvilli, presence of myeloid bodies, and no changes in the nucleus. Which type of cell injury is seen in this patient?

Accepted Answer

Reversible cell injury

Answer

Irreversible cell injury

Answer

Autolysis

Answer

Pyroptosis

Question 8

Which of the following conditions does NOT show the presence of fibrinoid necrosis?

Accepted Answer

Diabetic Glomerulosclerosis

Answer

Systemic Lupus Erythematosus (SLE)

Answer

Polyarteritis Nodosa (PAN)

Answer

Subacute Bacterial Endocarditis (SABE)

Question 9

A child presents with a 15-day history of cough and examination reveals cervical lymphadenopathy. Lymph node biopsy shows Langerhans giant cells. What is the most likely diagnosis?

Accepted Answer

Tuberculosis

Answer

Leprosy

Answer

Sarcoidosis

Answer

Syphilis

Question 10

Which of the following conditions is due to deposition of cholesterol?

Accepted Answer

Cholesterol

Answer

Glycogen

Answer

Water

Answer

Calcium

General Pathology — MCQs

General Pathology — MCQs

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